Publications by authors named "Sean H Lim"

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Association between COVID-19 vaccine immunogenicity and protection against infection and severe disease in clinically vulnerable patient populations: a systematic review and meta-analysis of observational studies.
Maria Danysz, Rute Cardoso De Aguiar, Hema Pindolia, Beth Stuart, Katrina Spensley, Sean H Lim

Clin Microbiol Infect· January 2026

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A "Function-First" Approach to Identify Regulatory T cell-Targeting Antibodies for Immunotherapy.
Kirstie L S Cleary, Monika Semmrich, Linda Martensson, Ulla-Carin Tornberg, David Ermert, Sean H Lim

Cancer Immunol Res· December 2025

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Harnessing multivalency and FcγRIIB engagement to augment anti-CD27 immunotherapy.
Marcus A Widdess, Anastasia Pakidi, Hannah J Metcalfe, H T Claude Chan, Tatyana Inzhelevskaya, Sean H Lim

Nat Commun· December 2025

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CD27 Agonist Antibodies Mediate Clinical Responses through Intratumoral Stimulation in B-cell Malignancies: Multicenter RiVa Trial.
Lara E Buermann, Louise Stanton, Matthew J J Rose-Zerilli, Kerensa Thorne, Adam Coleman, Sean H Lim

Clin Cancer Res· November 2025

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Impact of SARS-CoV-2 spike antibody positivity on infection and hospitalisation rates in immunosuppressed populations during the omicron period: the MELODY study.
Lisa Mumford, Rachel Hogg, Adam Taylor, Peter Lanyon, Mary Bythell, Sean H Lim

Lancet· January 2025

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Greater preservation of SARS-CoV-2 neutralising antibody responses following the ChAdOx1-S (AZD1222) vaccine compared with mRNA vaccines in haematopoietic cell transplant recipients.
Hayley Colton, Natalie Barratt, Nigel Temperton, Hailey Hornsby, Adrienn Angyal, Sean H Lim

Br J Haematol· December 2024

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Immunogenicity of third dose COVID-19 vaccine strategies in patients who are immunocompromised with suboptimal immunity following two doses (OCTAVE-DUO): an open-label, multicentre, randomised, controlled, phase 3 trial.
Carl S Goodyear, Amit Patel, Eleanor Barnes, Michelle Willicombe, Stefan Siebert, Sean H Lim, Zixiang Lim

Lancet Rheumatol· June 2024

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Agonist Antibodies for Cancer Immunotherapy: History, Hopes, and Challenges.
Sean H Lim, Stephen A Beers, Aymen Al-Shamkhani, Mark S Cragg

Clin Cancer Res· May 2024

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Antibody prevalence after three or more COVID-19 vaccine doses in individuals who are immunosuppressed in the UK: a cross-sectional study from MELODY.
Fiona A Pearce, Sean H Lim, Mary Bythell, Peter Lanyon, Rachel Hogg

Lancet Rheumatol· August 2023

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Predicting COVID-19 infection risk in people who are immunocompromised by antibody testing.
Ratna Wijaya, Marina Johnson, Nicola Campbell, Beth Stuart, Adam Kelly, Victoria Willimott, Sean H Lim

Lancet· July 2023

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SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease.
Eleanor Barnes, Carl S Goodyear, Michelle Willicombe, Charlotte Gaskell, Stefan Siebert, Zixiang Lim, Sean H Lim

Nat Med· July 2023

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Two approaches to tackling COVID-19 in patients with blood cancer.
Ratna Wijaya, Sean H Lim

Nat Cancer· January 2023

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COVID-19 infection in primary central nervous system lymphoma treatment: Who is most at risk?
Sean H Lim

Br J Haematol· November 2022

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Immune responses against SARS-CoV-2 variants after two and three doses of vaccine in B-cell malignancies: UK PROSECO study.
Sean H Lim, Beth Stuart, Debora Joseph-Pietras, Marina Johnson, Nicola Campbell, Victoria Willimott

Nat Cancer· May 2022

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Agonistic CD27 antibody potency is determined by epitope-dependent receptor clustering augmented through Fc-engineering.
Franziska Heckel, Anna H Turaj, Hayden Fisher, H T Claude Chan, Michael J E Marshall, Sean H Lim

Commun Biol· March 2022

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Antibody responses after SARS-CoV-2 vaccination in patients with lymphoma.
Sean H Lim, Nicola Campbell, Marina Johnson, Debora Joseph-Pietras, Graham P Collins

Lancet Haematol· August 2021

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Cyclophosphamide Enhances Cancer Antibody Immunotherapy in the Resistant Bone Marrow Niche by Modulating Macrophage FcγR Expression.
Ali Roghanian, Guangan Hu, Christopher Fraser, Maneesh Singh, Russell B Foxall, Sean H Lim

Cancer Immunol Res· November 2019

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RIVA - a phase IIa study of rituximab and varlilumab in relapsed or refractory B-cell malignancies: study protocol for a randomized controlled trial.
Sean H Lim, Kim M Linton, Graham P Collins, Joke Dhondt, Joshua Caddy

Trials· November 2018

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Optimizing therapy in advanced-stage Hodgkin lymphoma.
Sean H Lim, Peter W M Johnson

Blood· April 2018

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Augmentation of CD134 (OX40)-dependent NK anti-tumour activity is dependent on antibody cross-linking.
Anna H Turaj, Kerry L Cox, Christine A Penfold, Ruth R French, C Ian Mockridge, Sean H Lim

Sci Rep· February 2018

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Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment.
Anna H Turaj, Khiyam Hussain, Kerry L Cox, Matthew J J Rose-Zerilli, James Testa, Sean H Lim

Cancer Cell· December 2017

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TLR-3/9 Agonists Synergize with Anti-ErbB2 mAb-Letter.
Anna H Turaj, Lekh N Dahal, Stephen A Beers, Mark S Cragg, Sean H Lim

Cancer Res· June 2017

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Development and Characterization of Monoclonal Antibodies Specific for Mouse and Human Fcγ Receptors.
Alison L Tutt, Sonya James, Stéphanie A Laversin, Thomas R W Tipton, Margaret Ashton-Key, Sean H Lim

J Immunol· December 2015

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Translational medicine in action: anti-CD20 therapy in lymphoma.
Sean H Lim, Ronald Levy

J Immunol· August 2014

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Inhibitory FcγRIIb (CD32b) becomes activated by therapeutic mAb in both cis and trans and drives internalization according to antibody specificity.
Andrew T Vaughan, Chisako Iriyama, Stephen A Beers, Claude H T Chan, Sean H Lim

Blood· January 2014

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