Publications by authors named "Sebastian Demkowicz"

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8-(4-Trifluoromethylthio)benzylamino-2'-deoxyadenosine: a purine nucleoside as a potential radiosensitizer.
Magdalena Datta, Adrian Szczyrba, Patryk Nowak, Magdalena Zdrowowicz, Michał Rychłowski, Sebastian Demkowicz

Eur J Med Chem· December 2025

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A novel method for the mechanochemical synthesis of unsymmetrical disulfides using phosphorodithioic acid derivatives.
Mikołaj Walter, Agata Grobelna, Janusz Rachoń, Dariusz Witt, Sebastian Demkowicz

Sci Rep· December 2025

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Radiosensitization of Cancer Cells by 5-Selenocyanato- and 5-Trifluoromethanesulfonyl- Derivatives of 2'-deoxyuridine.
Magdalena Zdrowowicz, Magdalena Datta, Karol Biernacki, Agnieszka Manikowska, Emilia Mykowska, Sebastian Demkowicz

Radiat Res· October 2025

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Novel nonsteroidal steroid sulfatase inhibitors containing glutamic acid unit.
Olga Ciupak, Sebastian Demkowicz, Janusz Rachon, Karol Biernacki, Paweł Czubak

Eur J Med Chem· July 2025

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Substituted benzylamino-2'-deoxyadenosine a modified nucleoside with radiosensitizing properties.
Magdalena Datta, Adrian Szczyrba, Anna Czaja, Magdalena Zdrowowicz, Sebastian Demkowicz

Sci Rep· May 2025

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Development of potent and effective SARS-CoV-2 main protease inhibitors based on maleimide analogs for the potential treatment of COVID-19.
Karol Biernacki, Olga Ciupak, Mateusz Daśko, Janusz Rachon, Damian Flis, Sebastian Demkowicz

J Enzyme Inhib Med Chem· December 2024

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Accelerated remyelination and immune modulation by the EBI2 agonist 7α,25-dihydroxycholesterol analogue in the cuprizone model.
Klaudia Konieczna-Wolska, Fionä Caratis, Mikołaj Opiełka, Karol Biernacki, Krzysztof Urbanowicz, Sebastian Demkowicz

Biomed Pharmacother· December 2024

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Surprising Radiolytic Stability of 8-Thiomethyladenine in an Aqueous Solution.
Magdalena Datta, Adrian Szczyrba, Magdalena Zdrowowicz, Dariusz Wyrzykowski, Olga Ciupak, Sebastian Demkowicz

J Phys Chem B· April 2024

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Convenient and efficient N-methylation of secondary amines under solvent-free ball milling conditions.
Mikołaj Walter, Olga Ciupak, Karol Biernacki, Janusz Rachoń, Dariusz Witt, Sebastian Demkowicz

Sci Rep· April 2024

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Dissociative Electron Attachment to 5-Iodo-4-thio-2'-deoxyuridine: A Potential Radiosensitizer of Hypoxic Cells.
Muhammad Saqib, Eugene Arthur-Baidoo, Farhad Izadi, Adrian Szczyrba, Magdalena Datta, Sebastian Demkowicz

J Phys Chem Lett· October 2023

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Electron-Induced Decomposition of 5-Bromo-4-thiouracil and 5-Bromo-4-thio-2'-deoxyuridine: The Effect of the Deoxyribose Moiety on Dissociative Electron Attachment.
Farhad Izadi, Adrian Szczyrba, Magdalena Datta, Olga Ciupak, Sebastian Demkowicz

Int J Mol Sci· May 2023

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Intramolecular Proton Transfer in the Radical Anion of Cytidine Monophosphate Sheds Light on the Sensitivities of Dry vs Wet DNA to Electron Attachment-Induced Damage.
Lidia Chomicz-Mańka, Anna Czaja, Karina Falkiewicz, Magdalena Zdrowowicz, Karol Biernacki, Sebastian Demkowicz

J Am Chem Soc· April 2023

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Design, synthesis and biological evaluation of novel -phosphorylated and -phosphorylated tacrine derivatives as potential drugs against Alzheimer's disease.
Maja Przybyłowska, Krystyna Dzierzbicka, Szymon Kowalski, Sebastian Demkowicz, Mateusz Daśko

J Enzyme Inhib Med Chem· December 2022

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Development of Sulfamoylated 4-(1-Phenyl-1-1,2,3-triazol-4-yl)phenol Derivatives as Potent Steroid Sulfatase Inhibitors for Efficient Treatment of Breast Cancer.
Karol Biernacki, Olga Ciupak, Mateusz Daśko, Janusz Rachon, Witold Kozak, Sebastian Demkowicz

J Med Chem· March 2022

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New potent steroid sulphatase inhibitors based on 6-(1-phenyl-1-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives.
Olga Ciupak, Mateusz Daśko, Karol Biernacki, Janusz Rachon, Maciej Masłyk, Sebastian Demkowicz

J Enzyme Inhib Med Chem· December 2021

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Hydration of Simple Model Peptides in Aqueous Osmolyte Solutions.
Aneta Panuszko, Maciej Pieloszczyk, Anna Kuffel, Karol Jacek, Karol A Biernacki, Sebastian Demkowicz

Int J Mol Sci· August 2021

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Novel 1,2,3-Triazole Derivatives as Mimics of Steroidal System-Synthesis, Crystal Structures Determination, Hirshfeld Surfaces Analysis and Molecular Docking.
Mateusz Daśko, Anna Dołęga, Magdalena Siedzielnik, Karol Biernacki, Olga Ciupak, Sebastian Demkowicz

Molecules· July 2021

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Synthesis and Cholinesterase Inhibitory Activity of N-Phosphorylated/ N-Tiophosphorylated Tacrine.
Maja Przybyłowska, Iwona Inkielewicz-Stepniak, Szymon Kowalski, Krystyna Dzierzbicka, Sebastian Demkowicz

Med Chem· June 2021

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Electron-Induced Decomposition of Uracil-5-yl (,-dimethylsulfamate): Role of Methylation in Molecular Stability.
Eugene Arthur-Baidoo, Karina Falkiewicz, Lidia Chomicz-Mańka, Anna Czaja, Sebastian Demkowicz

Int J Mol Sci· February 2021

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Recent progress in the development of steroid sulphatase inhibitors - examples of the novel and most promising compounds from the last decade.
Mateusz Daśko, Sebastian Demkowicz, Karol Biernacki, Olga Ciupak, Witold Kozak

J Enzyme Inhib Med Chem· December 2020

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New potent STS inhibitors based on fluorinated 4-(1-phenyl-1-[1,2,3]triazol-4-yl)-phenyl sulfamates.
Mateusz Daśko, Sebastian Demkowicz, Janusz Rachon, Karol Biernacki, Justyna Aszyk

J Asian Nat Prod Res· November 2020

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Novel 1,2,4-Oxadiazole Derivatives in Drug Discovery.
Karol Biernacki, Mateusz Daśko, Olga Ciupak, Konrad Kubiński, Janusz Rachon, Sebastian Demkowicz

Pharmaceuticals (Basel)· May 2020

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Novel steroid sulfatase inhibitors based on N-thiophosphorylated 3-(4-aminophenyl)-coumarin-7-O-sulfamates.
Mateusz Daśko, Sebastian Demkowicz, Karol Biernacki, Amira Harrous, Janusz Rachon

Drug Dev Res· September 2019

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Synthesis and biological evaluation of N-acylated tyramine sulfamates containing C-F bonds as steroid sulfatase inhibitors.
Mateusz Daśko, Janusz Rachon, Maciej Masłyk, Konrad Kubiński, Sebastian Demkowicz

Chem Biol Drug Des· July 2017

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Synthesis and biological evaluation of fluorinated N-benzoyl and N-phenylacetoyl derivatives of 3-(4-aminophenyl)-coumarin-7-O-sulfamate as steroid sulfatase inhibitors.
Mateusz Daśko, Maja Przybyłowska, Janusz Rachon, Maciej Masłyk, Konrad Kubiński, Sebastian Demkowicz

Eur J Med Chem· March 2017

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