Publications by authors named "Sebastien Malinge"

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Perspectives on the origin and therapeutic opportunities in Down syndrome-associated leukemia.
Kunjal Panchal, Jesse Armitage, Laurence C Cheung, Rishi S Kotecha, Sébastien Malinge

Cancer Metastasis Rev· September 2025

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Preclinical Assessment of Dactinomycin in -Rearranged Infant Acute Lymphoblastic Leukemia.
Sung K Chiu, Emanuela Ferrari, Joyce Oommen, Sebastien Malinge, Laurence C Cheung

Cancers (Basel)· February 2025

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Targeting osteoclasts for treatment of high-risk B-cell acute lymphoblastic leukemia.
Rishi S Kotecha, Sarah M Trinder, Anastasia M Hughes, Benjamin H Mullin, Sarah Rashid, Sebastien Malinge

Blood Cancer J· February 2025

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Disruption of cotranscriptional splicing suggests RBM39 is a therapeutic target in acute lymphoblastic leukemia.
Qi Jin, Ethan Harris, Jacquelyn A Myers, Rashid Mehmood, Anitria Cotton, Sebastien Malinge

Blood· December 2024

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Childhood leukaemia in Down's syndrome primed by blood-cell bias.
Sébastien Malinge

Nature· October 2024

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Efficacy of DYRK1A inhibitors in novel models of Down syndrome acute lymphoblastic leukemia.
Shannon L Carey-Smith, Maryam H Simad, Kunjal Panchal, Carlos Aya-Bonilla, Hannah Smolders, Sébastien Malinge

Haematologica· July 2024

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Insights into the Clinical, Biological and Therapeutic Impact of Copy Number Alteration in Cancer.
Shannon L Carey-Smith, Rishi S Kotecha, Laurence C Cheung, Sébastien Malinge

Int J Mol Sci· June 2024

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Down syndrome and leukemia: from basic mechanisms to clinical advances.
André Baruchel, Jean-Pierre Bourquin, John Crispino, Sergi Cuartero, Henrik Hasle, Sébastien Malinge

Haematologica· October 2023

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A biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors.
Maria Eugénia Marques Da Costa, Sakina Zaidi, Jean-Yves Scoazec, Robin Droit, Wan Ching Lim, Sébastien Malinge

Commun Biol· September 2023

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It is more "unbalanced" than you think.
Sébastien Malinge

Blood· March 2023

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Preclinical efficacy of azacitidine and venetoclax for infant KMT2A-rearranged acute lymphoblastic leukemia reveals a new therapeutic strategy.
Laurence C Cheung, Carlos Aya-Bonilla, Mark N Cruickshank, Sung K Chiu, Vincent Kuek, Sébastien Malinge

Leukemia· January 2023

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Characterization of mesenchymal stem cells in pre-B acute lymphoblastic leukemia.
Anastasia M Hughes, Vincent Kuek, Joyce Oommen, Grace-Alyssa Chua, Maria van Loenhout, Sebastien Malinge

Front Cell Dev Biol· January 2023

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Stepwise GATA1 and SMC3 mutations alter megakaryocyte differentiation in a Down syndrome leukemia model.
Brahim Arkoun, Elie Robert, Fabien Boudia, Stefania Mazzi, Virginie Dufour, Sébastien Malinge

J Clin Invest· July 2022

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Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society.
Mara Dierssen, Yann Herault, Pablo Helguera, Maria Martínez de Lagran, Anna Vazquez, Sébastien Malinge

Mol Syndromol· July 2021

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Preclinical Evaluation of Carfilzomib for Infant -Rearranged Acute Lymphoblastic Leukemia.
Laurence C Cheung, Rebecca de Kraa, Joyce Oommen, Grace-Alyssa Chua, Sajla Singh, Sébastien Malinge

Front Oncol· April 2021

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DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3.
Rahul S Bhansali, Malini Rammohan, Paul Lee, Anouchka P Laurent, Qiang Wen, Sébastien Malinge

J Clin Invest· January 2021

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The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolution.
Denise Anderson, Patrycja Skut, Anastasia M Hughes, Emanuela Ferrari, Jennifer Tickner, Sébastien Malinge

Sci Rep· November 2020

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Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers.
Alexandre Fagnan, Frederik Otzen Bagger, Maria-Riera Piqué-Borràs, Cathy Ignacimouttou, Alexis Caulier, Sébastien Malinge

Blood· August 2020

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Gain of chromosome 21 in hematological malignancies: lessons from studying leukemia in children with Down syndrome.
Anouchka P Laurent, Rishi S Kotecha, Sébastien Malinge

Leukemia· August 2020

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SNAIL trail in myeloid malignancies.
Sébastien Malinge

Blood· August 2020

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Constitutive Activation of RAS/MAPK Pathway Cooperates with Trisomy 21 and Is Therapeutically Exploitable in Down Syndrome B-cell Leukemia.
Anouchka P Laurent, Aurélie Siret, Cathy Ignacimouttou, Kunjal Panchal, M'Boyba Diop, Sebastien Malinge

Clin Cancer Res· July 2020

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Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene-Driven Myeloid Leukemia.
Cécile K Lopez, Esteve Noguera, Vaia Stavropoulou, Elie Robert, Zakia Aid, Sébastien Malinge

Cancer Discov· December 2019

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Romidepsin enhances the efficacy of cytarabine , revealing histone deacetylase inhibition as a promising therapeutic strategy for -rearranged infant acute lymphoblastic leukemia.
Laurence C Cheung, Mark N Cruickshank, Anastasia M Hughes, Sajla Singh, Grace-Alyssa Chua, Sébastien Malinge

Haematologica· July 2019

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A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis.
Andrew Volk, Kaiwei Liang, Praveen Suraneni, Xinyu Li, Jianyun Zhao, Sebastien Malinge

Cancer Cell· November 2018

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