Publications by authors named "Sebo Withoff"

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High-resolution analysis of the treated coeliac disease microbiome reveals strain-level variation.
Jelle Slager, Hanna L Simpson, Ranko Gacesa, Lianmin Chen, Ineke L Tan, Sebo Withoff

Gut Microbes· December 2025

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Genetic differences between diagnosed and undiagnosed Celiac disease: a population-based study.
Mohammad Sayeef Alam, Brooke N Wolford, Kristian Hveem, Knut E A Lundin, Sebo Withoff

Hum Genet· December 2025

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Cytokine-induced memory-like responses in endothelial cells link chronic inflammation to vascular disease risk.
Kieu T T Le, Nick Keur, Heleen Middelkamp, Thuy Linh Do, Albert van den Berg, Sebo Withoff

Mol Omics· December 2025

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Gene expression profiling reveals enhanced nutrient and drug metabolism and maturation of hiPSC-derived intestine-on-chip relative to organoids and Transwells.
Renée Moerkens, Joram Mooiweer, Eline Smits, Marijn Berg, Aarón D Ramírez-Sánchez, Sebo Withoff

Stem Cell Reports· December 2025

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Human gut M cells resemble dendritic cells and present gluten antigen.
Daisong Wang, Sangho Lim, Willine J van de Wetering, Carmen Lopez-Iglesias, Yuu Okura, Sebo Withoff

Nature· December 2025

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Transcriptomics and eQTLs reveal inflammatory heterogeneity in the duodenal lining in coeliac disease.
Aarón D Ramírez-Sánchez, Stephanie Zühlke, Raúl Aguirre-Gamboa, Martijn Vochteloo, Lude Franke, Sebo Withoff

Genes Immun· October 2025

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Population screening of adults identifies novel genetic variants associated with celiac disease.
Mohammad Sayeef Alam, Laurent Thomas, Ben Brumpton, Kristian Hveem, Knut E A Lundin, Sebo Withoff

Sci Rep· June 2025

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Shared Genetics in Celiac Disease and Inflammatory Bowel Disease Specify a Greater Role for Intestinal Epithelial Cells.
Nathan Vinícius Ribeiro, Sajid Anwar, Sebo Withoff, Iris H Jonkers

Int J Mol Sci· March 2025

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Human organoids and organ-on-chips in coeliac disease research.
Hanna L Simpson, Eline Smits, Renée Moerkens, Cisca Wijmenga, Joram Mooiweer, Sebo Withoff

Trends Mol Med· February 2025

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Standardizing designed and emergent quantitative features in microphysiological systems.
Dennis M Nahon, Renée Moerkens, Hande Aydogmus, Bas Lendemeijer, Adriana Martínez-Silgado, Sebo Withoff

Nat Biomed Eng· August 2024

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An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal, and neural cells.
Renée Moerkens, Joram Mooiweer, Aarón D Ramírez-Sánchez, Roy Oelen, Lude Franke, Sebo Withoff

Cell Rep· July 2024

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Potential biomarkers for multiple sclerosis stage from targeted proteomics and microRNA sequencing.
Ineke L Tan, Rutger Modderman, Anna Stachurska, Rodrigo Almeida, Riemer de Vries, Sebo Withoff

Brain Commun· June 2024

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Genetic mapping across autoimmune diseases reveals shared associations and mechanisms.
Matthew R Lincoln, Noah Connally, Pierre-Paul Axisa, Christiane Gasperi, Mitja Mitrovic, Sebo Withoff

Nat Genet· May 2024

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Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire.
Sergio Andreu-Sánchez, Arno R Bourgonje, Thomas Vogl, Alexander Kurilshikov, Sigal Leviatan, Sebo Withoff

Immunity· June 2023

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iPSC-derived organ-on-a-chip models for personalized human genetics and pharmacogenomics studies.
Victoria E J M Palasantzas, Isabel Tamargo-Rubio, Kieu Le, Jelle Slager, Cisca Wijmenga, Sebo Withoff

Trends Genet· April 2023

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Gut mucosa dissociation protocols influence cell type proportions and single-cell gene expression levels.
Werna T C Uniken Venema, Aarón D Ramírez-Sánchez, Emilia Bigaeva, Sebo Withoff, Iris Jonkers

Sci Rep· June 2022

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Single-Cell RNA Sequencing of Peripheral Blood Mononuclear Cells From Pediatric Coeliac Disease Patients Suggests Potential Pre-Seroconversion Markers.
Aarón D Ramírez-Sánchez, Xiaojing Chu, Rutger Modderman, Yvonne Kooy-Winkelaar, Sibylle Koletzko, Sebo Withoff

Front Immunol· April 2022

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Circulating miRNAs as Potential Biomarkers for Celiac Disease Development.
Ineke L Tan, Rodrigo Coutinho de Almeida, Rutger Modderman, Anna Stachurska, Jackie Dekens, Sebo Withoff

Front Immunol· February 2022

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Inflammatory Protein Profiles in Plasma of Candidaemia Patients and the Contribution of Host Genetics to Their Variability.
Vasiliki Matzaraki, Kieu T T Le, Martin Jaeger, Raúl Aguirre-Gamboa, Melissa D Johnson, Sebo Withoff

Front Immunol· October 2021

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A Combined mRNA- and miRNA-Sequencing Approach Reveals miRNAs as Potential Regulators of the Small Intestinal Transcriptome in Celiac Disease.
Ineke Luise Tan, Donatella Barisani, Roberto Panceri, Rutger Modderman, Marijn Visschedijk, Sebo Withoff

Int J Mol Sci· October 2021

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Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease.
Xiaojing Chu, Martin Jaeger, Joep Beumer, Olivier B Bakker, Raul Aguirre-Gamboa, Sebo Withoff

Genome Biol· July 2021

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Long Non-Coding RNAs Involved in Progression of Non-Alcoholic Fatty Liver Disease to Steatohepatitis.
Biljana Atanasovska, Sander S Rensen, Glenn Marsman, Ronit Shiri-Sverdlov, Sebo Withoff

Cells· July 2021

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Potential impact of celiac disease genetic risk factors on T cell receptor signaling in gluten-specific CD4+ T cells.
Olivier B Bakker, Aarón D Ramírez-Sánchez, Zuzanna A Borek, Niek de Klein, Yang Li, Sebo Withoff

Sci Rep· April 2021

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Non-classical clinical presentation at diagnosis by male celiac disease patients of older age.
Ineke L Tan, Sebo Withoff, Jeroen J Kolkman, Cisca Wijmenga, Rinse K Weersma

Eur J Intern Med· January 2021

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Systematic Prioritization of Candidate Genes in Disease Loci Identifies as a Master Regulator of IFNγ Signaling in Celiac Disease.
Adriaan van der Graaf, Maria M Zorro, Annique Claringbould, Urmo Võsa, Raúl Aguirre-Gamboa, Sebo Withoff

Front Genet· January 2021

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