Publications by authors named "Senthil T Kumar"

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Nanoplasmonic Infrared Microarray Sensor Enabling Structural Protein Biomarker-Based Drug Screening for Neurodegenerative Diseases.
Deepthy Kavungal, Enzo Morro, Senthil T Kumar, Berkay Dagli, Hilal A Lashuel

Adv Sci (Weinh)· October 2025

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Medin drives Aβ40 to adopt Aβ42-like fibril polymorphs in vitro.
Brajabandhu Pradhan, Senthil T Kumar, Jessica Wagner, Rodrigo Gallardo, Gabriele Orlando

bioRxiv· July 2025

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Author Correction: Development and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseases.
Melek Firat Altay, Senthil T Kumar, Johannes Burtscher, Somanath Jagannath, Catherine Strand

NPJ Parkinsons Dis· January 2024

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Development and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseases.
Melek Firat Altay, Senthil T Kumar, Johannes Burtscher, Somanath Jagannath, Catherine Strand

NPJ Parkinsons Dis· December 2023

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Artificial intelligence-coupled plasmonic infrared sensor for detection of structural protein biomarkers in neurodegenerative diseases.
Deepthy Kavungal, Pedro Magalhães, Senthil T Kumar, Rajasekhar Kolla, Hilal A Lashuel

Sci Adv· July 2023

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Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage.
Senthil T Kumar, Sergey Nazarov, Sílvia Porta, Niran Maharjan, Urszula Cendrowska

Nat Neurosci· June 2023

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A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity.
Senthil T Kumar, Anne-Laure Mahul-Mellier, Ramanath Narayana Hegde, Gwladys Rivière, Rani Moons

Sci Adv· April 2022

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How specific are the conformation-specific α-synuclein antibodies? Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structures and morphology.
Senthil T Kumar, Somanath Jagannath, Cindy Francois, Hugo Vanderstichele, Erik Stoops

Neurobiol Dis· December 2020

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A simple, versatile and robust centrifugation-based filtration protocol for the isolation and quantification of α-synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in α-synuclein research.
Senthil T Kumar, Sonia Donzelli, Anass Chiki, Muhammed Muazzam Kamil Syed, Hilal A Lashuel

J Neurochem· April 2020

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Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM.
Urszula Cendrowska, Paulo Jacob Silva, Nadine Ait-Bouziad, Marie Müller, Zekiye Pelin Guven, Senthil T Kumar

Proc Natl Acad Sci U S A· March 2020

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Chronic corticosterone aggravates behavioral and neuronal symptomatology in a mouse model of alpha-synuclein pathology.
Johannes Burtscher, Jean-Christophe Copin, João Rodrigues, Senthil T Kumar, Anass Chiki

Neurobiol Aging· November 2019

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Molecular architecture of Aβ fibrils grown in cerebrospinal fluid solution and in a cell culture model of Aβ plaque formation.
Megan Garvey, Monika Baumann, Melanie Wulff, Senthil T Kumar, Daniel Markx

Amyloid· June 2016

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Solvent Removal Induces a Reversible β-to-α Switch in Oligomeric Aβ Peptide.
Senthil T Kumar, Jörg Leppert, Peter Bellstedt, Christoph Wiedemann, Marcus Fändrich

J Mol Biol· January 2016

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Structural characterization of amyloid fibrils from the human parathyroid hormone.
Mohanraj Gopalswamy, Amit Kumar, Juliane Adler, Monika Baumann, Mathias Henze, Senthil T Kumar

Biochim Biophys Acta· April 2015

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Structure and biomedical applications of amyloid oligomer nanoparticles.
Senthil T Kumar, Jessica Meinhardt, Ann-Kathrin Fuchs, Tobias Aumüller, Jörg Leppert

ACS Nano· November 2014

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Liquefaction of semen generates and later degrades a conserved semenogelin peptide that enhances HIV infection.
Nadia R Roan, Haichuan Liu, Shariq M Usmani, Jason Neidleman, Janis A Müller, Senthil T Kumar

J Virol· July 2014

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Pattern recognition with a fibril-specific antibody fragment reveals the surface variability of natural amyloid fibrils.
Christian Haupt, Magdalena Bereza, Senthil T Kumar, Barbara Kieninger, Isabel Morgado

J Mol Biol· May 2011

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Amyloid fibril recognition with the conformational B10 antibody fragment depends on electrostatic interactions.
Christian Haupt, Isabel Morgado, Senthil T Kumar, Christoph Parthier, Magdalena Bereza

J Mol Biol· January 2011

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Disulfide conformation and design at helix N-termini.
S Indu, Senthil T Kumar, Sudhir Thakurela, Mansi Gupta, Ramachandra M Bhaskara

Proteins· April 2010

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