Publications by authors named "Sergio A Rodriguez-Aponte"

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Engineered antibodies that stabilize drug-modified KRAS neoantigens enable selective and potent cross-HLA immunotherapy.
Lorenzo Maso, Sarah A Mosure, Sergio A Rodriguez-Aponte, Angelina Pizzo, Diamond N Mensah

Nat Commun· December 2025

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Adaptation of Aglycosylated Monoclonal Antibodies for Improved Production in Komagataella phaffii.
Yuchen Yang, Neil C Dalvie, Joseph R Brady, Christopher A Naranjo, Timothy Lorgeree, Sergio A Rodriguez-Aponte

Biotechnol Bioeng· February 2025

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Minimal purification method enables developability assessment of recombinant proteins.
Sergio A Rodriguez-Aponte, Christopher A Naranjo, Ryan S Johnston, Neil C Dalvie, Laura E Crowell

Biotechnol Bioeng· August 2024

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CRISPR-Cas9 knockout screen informs efficient reduction of the Komagataella phaffii secretome.
Neil C Dalvie, Timothy R Lorgeree, Yuchen Yang, Sergio A Rodriguez-Aponte, Charles A Whittaker

Microb Cell Fact· July 2024

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Vaccine targeting to mucosal lymphoid tissues promotes humoral immunity in the gastrointestinal tract.
Ozgun Kocabiyik, Parastoo Amlashi, A Lina Vo, Heikyung Suh, Sergio A Rodriguez-Aponte

Sci Adv· May 2024

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Large-Scale Purification and Characterization of Recombinant Receptor-Binding Domain (RBD) of SARS-CoV-2 Spike Protein Expressed in Yeast.
Gaurav Nagar, Siddharth Jain, Meghraj Rajurkar, Rakesh Lothe, Harish Rao, Sergio A Rodriguez-Aponte

Vaccines (Basel)· October 2023

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Nanoalum Formulations Containing Aluminum Hydroxide and CpG 1018 Adjuvants: The Effect on Stability and Immunogenicity of a Recombinant SARS-CoV-2 RBD Antigen.
Sakshi Bajoria, Ozan S Kumru, Jennifer Doering, Katherine Berman, Greta Van Slyke, Sergio A Rodriguez-Aponte

Vaccines (Basel)· May 2023

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Molecular engineering of a cryptic epitope in Spike RBD improves manufacturability and neutralizing breadth against SARS-CoV-2 variants.
Sergio A Rodriguez-Aponte, Neil C Dalvie, Ting Y Wong, Ryan S Johnston, Christopher A Naranjo

Vaccine· January 2023

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Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG adjuvants.
Sakshi Bajoria, Kawaljit Kaur, Ozan S Kumru, Greta Van Slyke, Jennifer Doering

Hum Vaccin Immunother· November 2022

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Steric accessibility of the N-terminus improves the titer and quality of recombinant proteins secreted from Komagataella phaffii.
Neil C Dalvie, Christopher A Naranjo, Sergio A Rodriguez-Aponte, Ryan S Johnston, J Christopher Love

Microb Cell Fact· September 2022

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RBD-VLP Vaccines Adjuvanted with Alum or SWE Protect K18-hACE2 Mice against SARS-CoV-2 VOC Challenge.
Ting Y Wong, Brynnan P Russ, Katherine S Lee, Olivia A Miller, Jason Kang, Sergio A Rodriguez-Aponte

mSphere· August 2022

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Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity.
Brittany L Hartwell, Mariane B Melo, Peng Xiao, Ashley A Lemnios, Na Li, Sergio A Rodriguez-Aponte

Sci Transl Med· July 2022

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SARS-CoV-2 receptor binding domain displayed on HBsAg virus-like particles elicits protective immunity in macaques.
Neil C Dalvie, Lisa H Tostanoski, Sergio A Rodriguez-Aponte, Kawaljit Kaur, Sakshi Bajoria

Sci Adv· March 2022

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Scalable, methanol-free manufacturing of the SARS-CoV-2 receptor-binding domain in engineered Komagataella phaffii.
Neil C Dalvie, Andrew M Biedermann, Sergio A Rodriguez-Aponte, Christopher A Naranjo, Harish D Rao

Biotechnol Bioeng· February 2022

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Modular development enables rapid design of media for alternative hosts.
Andrew M Biedermann, Isabella R Gengaro, Sergio A Rodriguez-Aponte, Kerry R Love, J Christopher Love

Biotechnol Bioeng· January 2022

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Phosphate-mediated coanchoring of RBD immunogens and molecular adjuvants to alum potentiates humoral immunity against SARS-CoV-2.
Kristen A Rodrigues, Sergio A Rodriguez-Aponte, Neil C Dalvie, Jeong Hyun Lee, Wuhbet Abraham

Sci Adv· December 2021

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Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice.
Neil C Dalvie, Sergio A Rodriguez-Aponte, Brittany L Hartwell, Lisa H Tostanoski, Andrew M Biedermann

Proc Natl Acad Sci U S A· September 2021

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A modular protein subunit vaccine candidate produced in yeast confers protection against SARS-CoV-2 in non-human primates.
Neil C Dalvie, Lisa H Tostanoski, Sergio A Rodriguez-Aponte, Kawaljit Kaur, Sakshi Bajoria

bioRxiv· July 2021

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Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus.
Neil C Dalvie, Joseph R Brady, Laura E Crowell, Mary Kate Tracey, Andrew M Biedermann, Sergio A Rodriguez-Aponte

Microb Cell Fact· May 2021

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Scalable, methanol-free manufacturing of the SARS-CoV-2 receptor binding domain in engineered .
Neil C Dalvie, Andrew M Biedermann, Sergio A Rodriguez-Aponte, Christopher A Naranjo, Harish D Rao

bioRxiv· April 2021

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Engineered SARS-CoV-2 receptor binding domain improves immunogenicity in mice and elicits protective immunity in hamsters.
Neil C Dalvie, Sergio A Rodriguez-Aponte, Brittany L Hartwell, Lisa H Tostanoski, Andrew M Biedermann

bioRxiv· March 2021

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