Publications by authors named "Severin Lechner"

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Inhibitors supercharge kinase turnover through native proteolytic circuits.
Natalie S Scholes, Martino Bertoni, Arnau Comajuncosa-Creus, Katharina Kladnik, Xuefei Guo, Severin Lechner

Nature· November 2025

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Serendipitous and Systematic Chemoproteomic Discovery of MBLAC2, HINT1, and NME1-4 Inhibitors from Histone Deacetylase-Targeting Pharmacophores.
Severin Lechner, Shuyao Sha, Jigar Paras Sethiya, Patrycja Szczupak, Rafal Dolot

ACS Chem Biol· June 2025

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Decrypting the molecular basis of cellular drug phenotypes by dose-resolved expression proteomics.
Stephan Eckert, Nicola Berner, Karl Kramer, Annika Schneider, Julian Müller, Severin Lechner

Nat Biotechnol· March 2025

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Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets.
Martin P Schwalm, Johannes Dopfer, Adarsh Kumar, Francesco A Greco, Nicolas Bauer, Severin Lechner

Nat Commun· November 2024

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Decrypting lysine deacetylase inhibitor action and protein modifications by dose-resolved proteomics.
Yun-Chien Chang, Christian Gnann, Raphael R Steimbach, Florian P Bayer, Severin Lechner

Cell Rep· June 2024

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A region-resolved proteomic map of the human brain enabled by high-throughput proteomics.
Johanna Tüshaus, Amirhossein Sakhteman, Severin Lechner, Matthew The, Eike Mucha

EMBO J· December 2023

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High-Throughput Screening and Proteomic Characterization of Compounds Targeting Myeloid-Derived Suppressor Cells.
Johannes Krumm, Elissaveta Petrova, Severin Lechner, Julia Mergner, Hans-Henning Boehm

Mol Cell Proteomics· September 2023

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Chemoproteomic target deconvolution reveals Histone Deacetylases as targets of (R)-lipoic acid.
Severin Lechner, Raphael R Steimbach, Longlong Wang, Marshall L Deline, Yun-Chien Chang

Nat Commun· June 2023

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Decrypting drug actions and protein modifications by dose- and time-resolved proteomics.
Jana Zecha, Florian P Bayer, Svenja Wiechmann, Julia Woortman, Nicola Berner, Severin Lechner

Science· April 2023

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Development of hetero-triaryls as a new chemotype for subtype-selective and potent Sirt5 inhibition.
Carina Glas, Eli Naydenova, Severin Lechner, Nathalie Wössner, Liu Yang

Eur J Med Chem· October 2022

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Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout.
Raphael R Steimbach, Corey J Herbst-Gervasoni, Severin Lechner, Tracy Murray Stewart, Glynis Klinke

J Am Chem Soc· October 2022

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Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target.
Severin Lechner, Martin Ian P Malgapo, Christian Grätz, Raphael R Steimbach, Agnes Baron

Nat Chem Biol· August 2022

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Author Correction: Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target.
Severin Lechner, Martin Ian P Malgapo, Christian Grätz, Raphael R Steimbach, Agnes Baron

Nat Chem Biol· August 2022

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