Publications by authors named "Shane D Hellyer"

Claim this Profile
P
Pharmacological characterisation of allosteric modulators at human mGlu.
Muhammad Abdur Razzak, Kevin Tran, Roisin McCague, Kathy Sengmany, Jackson Kos, Shane D Hellyer

Biochem Pharmacol· September 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structure-based discovery of positive allosteric modulators of the A adenosine receptor.
Anh T N Nguyen, Nicolas Panel, Duc Duy Vo, Bui San Thai, Ling Yeong Chia, Shane D Hellyer

Proc Natl Acad Sci U S A· July 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pharmacology, Signaling and Therapeutic Potential of Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators.
Jackson A Kos, Monica Langiu, Shane D Hellyer, Karen J Gregory

ACS Pharmacol Transl Sci· December 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
SCA44- and SCAR13-associated GRM1 mutations affect metabotropic glutamate receptor 1 function through distinct mechanisms.
Yuyang Wang, Ashwin Muraleetharan, Monica Langiu, Karen J Gregory, Shane D Hellyer

Br J Pharmacol· November 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
U
Unlocking the secrets of trace amine-associated receptor 1 agonists: new horizon in neuropsychiatric treatment.
Britto Shajan, Tarun Bastiampillai, Shane D Hellyer, Pramod C Nair

Front Psychiatry· October 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Trace amine associated receptor 1: predicted effects of single nucleotide variants on structure-function in geographically diverse populations.
Britto Shajan, Shashikanth Marri, Tarun Bastiampillai, Karen J Gregory, Shane D Hellyer

Hum Genomics· June 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
R
Rigorous Characterization of Allosteric Modulation of the Human Metabotropic Glutamate Receptor 1 Reveals Probe- and Assay-Dependent Pharmacology.
Ashwin Muraleetharan, Yuyang Wang, Matthew C Rowe, Ashleigh Gould, Karen J Gregory, Shane D Hellyer

Mol Pharmacol· June 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Publisher Correction to: Adenosine receptor signalling in Alzheimer's disease.
Phuc N H Trinh, Jo-Anne Baltos, Shane D Hellyer, Lauren T May, Karen J Gregory

Purinergic Signal· December 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Adenosine receptor signalling in Alzheimer's disease.
Phuc N H Trinh, Jo-Anne Baltos, Shane D Hellyer, Lauren T May, Karen J Gregory

Purinergic Signal· September 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Positive Allosteric Modulators of Metabotropic Glutamate Receptor 5 as Tool Compounds to Study Signaling Bias.
Angela Arsova, Thor C Møller, Shane D Hellyer, Line Vedel, Simon R Foster

Mol Pharmacol· May 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Differential contribution of metabotropic glutamate receptor 5 common allosteric binding site residues to biased allosteric agonism.
Kathy Sengmany, Shane D Hellyer, Arthur Christopoulos, David J Lapinsky, Katie Leach

Biochem Pharmacol· July 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Probe dependence and biased potentiation of metabotropic glutamate receptor 5 is mediated by differential ligand interactions in the common allosteric binding site.
Shane D Hellyer, Kathy Sengmany, Andrew N Keller, Arthur Christopoulos, Katie Leach

Biochem Pharmacol· July 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Identification of monellin as the first naturally derived proteinaceous allosteric agonist of metabotropic glutamate receptor 5.
Amy N Y Chen, Shane D Hellyer, Phuc N H Trinh, Katie Leach, Karen J Gregory

Basic Clin Pharmacol Toxicol· June 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Development of Clickable Photoaffinity Ligands for Metabotropic Glutamate Receptor 2 Based on Two Positive Allosteric Modulator Chemotypes.
Shane D Hellyer, Shaili Aggarwal, Amy N Y Chen, Katie Leach, David J Lapinsky

ACS Chem Neurosci· June 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Metabotropic glutamate receptor 5 (mGlu )-positive allosteric modulators differentially induce or potentiate desensitization of mGlu signaling in recombinant cells and neurons.
Shane D Hellyer, Sabine Albold, Kathy Sengmany, Junaid Singh, Katie Leach

J Neurochem· November 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
K
Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology.
Kathy Sengmany, Shane D Hellyer, Sabine Albold, Taide Wang, P Jeffrey Conn

Neuropharmacology· May 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
"
"Selective" Class C G Protein-Coupled Receptor Modulators Are Neutral or Biased mGlu Allosteric Ligands.
Shane D Hellyer, Sabine Albold, Taide Wang, Amy N Y Chen, Lauren T May

Mol Pharmacol· May 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pinnatoxins E, F and G target multiple nicotinic receptor subtypes.
Shane D Hellyer, Dinesh Indurthi, Thomas Balle, Vanda Runder-Varga, Andrew I Selwood

J Neurochem· November 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
In vitro labelling of muscle type nicotinic receptors using a fluorophore-conjugated pinnatoxin F derivative.
Shane D Hellyer, Andrew I Selwood, Roel van Ginkel, Rex Munday, Phil Sheard

Toxicon· September 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Neuromuscular blocking activity of pinnatoxins E, F and G.
Shane D Hellyer, Andrew I Selwood, Lesley Rhodes, D Steven Kerr

Toxicon· December 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Marine algal pinnatoxins E and F cause neuromuscular block in an in vitro hemidiaphragm preparation.
Shane D Hellyer, Andrew I Selwood, Lesley Rhodes, D Steven Kerr

Toxicon· December 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis