Publications by authors named "Shansen Xu"

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Valproic Acid Exacerbates Lipid Accumulation in High-Fat Hepatocytes Induced by Oleic Acid: Insights From Lipidomic Analysis.
Shansen Xu, Xianglei Ma, Lingli Huang, Tingting Yue, Ya'nan Chen

Lipids· January 2026

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Population Pharmacokinetics Model and Simulation of Unbound and Total Valproic Acid in Epileptic Children Using a Protein Binding Model.
Tingting Yue, Limei Zhao, Ya'nan Chen, Shansen Xu

Basic Clin Pharmacol Toxicol· December 2025

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Model-informed drug development in public health emergency of international concern: accelerating marketing authorization of simnotrelvir.
Bu-Fan Yao, Yang Yang, Shan-Sen Xu, Bo-Hao Tang, Jia Chen

Antimicrob Agents Chemother· November 2025

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F qNMR based pharmacokinetics, metabolism and mass balance studies of SARS-CoV-2-3CL protease inhibitor simnotrelvir (SIM0417) in humans.
Ze-Yu Wang, Yong-Mei Ren, Shu-Wei Hu, Nai-Xia Zhang, Meng-Xiao Dong, Shan-Sen Xu

Acta Pharmacol Sin· February 2025

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Drug-drug interactions of simnotrelvir/ritonavir: an open-label, fixed-sequence, two-period clinical trial.
Pan-Pan Ye, Bu-Fan Yao, Yang Yang, Xin-Mei Yang, Qian Li, Shan-Sen Xu

Clin Microbiol Infect· January 2025

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Mechanisms Underlying the Protective Effects of Obeticholic Acid-Activated FXR in Valproic Acid-Induced Hepatotoxicity via Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulations.
Ya'nan Chen, Jingkai Zhou, Shansen Xu, Lei Wang

Curr Comput Aided Drug Des· September 2024

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Model Informed Development of SIM0295 in Patients with Gout and Hyperuricemia and Healthy Volunteers Using a Population Pharmacokinetics/ Pharmacodynamics Approach.
Yueting Chen, Yang Yang, Shansen Xu, Chenyu Wang, Pan Shu

Expert Opin Investig Drugs· May 2023

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Association between the perturbation of bile acid homeostasis and valproic acid-induced hepatotoxicity.
Yanan Chen, Jingkai Zhou, Shansen Xu, Mei Liu, Minglu Wang

Biochem Pharmacol· December 2019

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Lipidomic Profiling Reveals Disruption of Lipid Metabolism in Valproic Acid-Induced Hepatotoxicity.
Shansen Xu, Yanan Chen, Yiyi Ma, Ting Liu, Mingming Zhao

Front Pharmacol· July 2019

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Cucurbitacin B suppresses proliferation of pancreatic cancer cells by ceRNA: Effect of miR-146b-5p and lncRNA-AFAP1-AS1.
Jingkai Zhou, Mei Liu, Yanan Chen, Shansen Xu, Yingjie Guo

J Cell Physiol· April 2019

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Dosage Optimization Based on Population Pharmacokinetic Analysis of Tacrolimus in Chinese Patients with Nephrotic Syndrome.
Tong Lu, Xu Zhu, Shansen Xu, Mingming Zhao, Xueshi Huang

Pharm Res· February 2019

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A Population Pharmacokinetic-Pharmacogenetic Model of Lamotrigine in Chinese Children With Epilepsy.
Yanan Chen, Shansen Xu, Zhanyou Wang, Mingming Zhao, Huanxin Wang

Ther Drug Monit· December 2018

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Population pharmacokinetics of valproic acid in epileptic children: Effects of clinical and genetic factors.
Shansen Xu, Yanan Chen, Mingming Zhao, Yingjie Guo, Zhanyou Wang

Eur J Pharm Sci· September 2018

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Population pharmacokinetics of lamotrigine co-administered with valproic acid in Chinese epileptic children using nonlinear mixed effects modeling.
Shansen Xu, Limin Liu, Yanan Chen, Mei Liu, Tong Lu

Eur J Clin Pharmacol· May 2018

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Development of a Simple and Rapid Method to Measure Free Fraction of Valproic Acid in Plasma Using Ultrafiltration and Ultra High Performance Liquid Chromatography-Mass Spectroscopy: Application to Therapeutic Drug Monitoring.
Shansen Xu, Yanan Chen, Mingming Zhao, Limei Zhao

Ther Drug Monit· October 2017

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Effects of Polymorphisms in NR1H4, NR1I2, SLCO1B1, and ABCG2 on the Pharmacokinetics of Rosuvastatin in Healthy Chinese Volunteers.
Mei Liu, Xiu-Jun Wu, Gui-Lian Zhao, Ti Zhang, Shan-Sen Xu

J Cardiovasc Pharmacol· November 2016

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