Publications by authors named "Sharyn Thomas"

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Exploitation of CD3ζ to enhance TCR expression levels and antigen-specific T cell function.
Abdullah Degirmencay, Sharyn Thomas, Angelika Holler, Samuel Burgess, Emma C Morris

Front Immunol· June 2024

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Modifications outside CDR1, 2 and 3 of the TCR variable β domain increase TCR expression and antigen-specific function.
Abdullah Degirmencay, Sharyn Thomas, Fiyaz Mohammed, Benjamin E Willcox, Hans J Stauss

Front Immunol· May 2023

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Forced Fox-P3 expression can improve the safety and antigen-specific function of engineered regulatory T cells.
Jenny McGovern, Angelika Holler, Sharyn Thomas, Hans J Stauss

J Autoimmun· October 2022

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Crispr/Cas Mediated Deletion of PTPN22 in Jurkat T Cells Enhances TCR Signaling and Production of IL-2.
Cara Bray, David Wright, Sonja Haupt, Sharyn Thomas, Hans Stauss

Front Immunol· October 2019

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Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function.
Sharyn Thomas, Fiyaz Mohammed, Rogier M Reijmers, Annemarie Woolston, Theresa Stauss

Nat Commun· October 2019

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Redirection to the bone marrow improves T cell persistence and antitumor functions.
Anjum B Khan, Ben Carpenter, Pedro Santos E Sousa, Constandina Pospori, Reema Khorshed, Sharyn Thomas

J Clin Invest· May 2018

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Functional comparison of engineered T cells carrying a native TCR versus TCR-like antibody-based chimeric antigen receptors indicates affinity/avidity thresholds.
Ravit Oren, Moran Hod-Marco, Maya Haus-Cohen, Sharyn Thomas, Dan Blat

J Immunol· December 2014

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Human MHC Class I-restricted high avidity CD4 T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo.
Shao-An Xue, Liquan Gao, Maryam Ahmadi, Sara Ghorashian, Rafael D Barros, Sharyn Thomas

Oncoimmunology· January 2013

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Human T cells expressing affinity-matured TCR display accelerated responses but fail to recognize low density of MHC-peptide antigen.
Sharyn Thomas, Shao-An Xue, Charles R M Bangham, Bent K Jakobsen, Emma C Morris

Blood· July 2011

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Molecular immunology lessons from therapeutic T-cell receptor gene transfer.
Sharyn Thomas, Hans J Stauss, Emma C Morris

Immunology· February 2010

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Development of a Wilms' tumor antigen-specific T-cell receptor for clinical trials: engineered patient's T cells can eliminate autologous leukemia blasts in NOD/SCID mice.
Shao-An Xue, Liquan Gao, Sharyn Thomas, Daniel P Hart, John Zhao Xue

Haematologica· January 2010

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IL15 can reverse the unresponsiveness of Wilms' tumor antigen-specific CTL in patients with prostate cancer.
Judy W King, Sharyn Thomas, Fabrizio Corsi, Liquan Gao, Roberto Dina

Clin Cancer Res· February 2009

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WT1-specific T cell receptor gene therapy: improving TCR function in transduced T cells.
Hans J Stauss, Sharyn Thomas, Michela Cesco-Gaspere, Daniel P Hart, Shao-An Xue

Blood Cells Mol Dis· February 2008

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Targeting the Wilms tumor antigen 1 by TCR gene transfer: TCR variants improve tetramer binding but not the function of gene modified human T cells.
Sharyn Thomas, Shao-An Xue, Michela Cesco-Gaspere, Esther San José, Daniel P Hart

J Immunol· November 2007

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Monoclonal T-cell receptors: new reagents for cancer therapy.
Hans J Stauss, Michela Cesco-Gaspere, Sharyn Thomas, Daniel P Hart, Shao-An Xue

Mol Ther· October 2007

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T-cell receptor gene therapy for cancer: the progress to date and future objectives.
Sharyn Thomas, Daniel P Hart, Shao-An Xue, Michela Cesco-Gaspere, Hans J Stauss

Expert Opin Biol Ther· August 2007

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Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation.
Sunil Shaunak, Sharyn Thomas, Elisabetta Gianasi, Antony Godwin, Emma Jones

Nat Biotechnol· August 2004

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