Publications by authors named "Shaun D Fontaine"

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Identifying a next-generation antimalarial trioxolane in a landscape of artemisinin partial resistance.
Matthew T Klope, Poulami Talukder, Brian R Blank, Sevil Chelebieva, Jun Chen, Shaun D Fontaine

Sci Adv· August 2025

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Antitumor activity of rucaparib plus PLX038A in serous endometrial carcinoma.
Xiaonan Hou, Valentina Zanfagnin, Conway Xu, Erik Jessen, Yuanhang Liu, Shaun D Fontaine

J Exp Clin Cancer Res· May 2025

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PET Imaging Using 89Zr-Labeled StarPEG Nanocarriers Reveals Heterogeneous Enhanced Permeability and Retention in Prostate Cancer.
Niranjan Meher, Anil P Bidkar, Anju Wadhwa, Kondapa Naidu Bobba, Suchi Dhrona, Shaun D Fontaine

Mol Cancer Ther· January 2025

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Long-Acting Poly(ADP-ribose) Polymerase Inhibitor Prodrug for Humans.
Christopher W Carreras, Shaun D Fontaine, Ralph R Reid, Gary W Ashley, Daniel V Santi

Bioconjug Chem· April 2024

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A Very Long-acting Exatecan and Its Synergism with DNA Damage Response Inhibitors.
Shaun D Fontaine, Christopher W Carreras, Ralph R Reid, Gary W Ashley, Daniel V Santi

Cancer Res Commun· May 2023

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PLX038: A Long-Acting Topoisomerase I Inhibitor With Robust Antitumor Activity in ATM-Deficient Tumors and Potent Synergy With PARP Inhibitors.
Anish Thomas, Shaun D Fontaine, Morgan E Diolaiti, Parth Desai, Rajesh Kumar

Mol Cancer Ther· November 2022

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Prostate-Specific Membrane Antigen Targeted Deep Tumor Penetration of Polymer Nanocarriers.
Niranjan Meher, Gary W Ashley, Anil P Bidkar, Suchi Dhrona, Cyril Fong, Shaun D Fontaine

ACS Appl Mater Interfaces· November 2022

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PEGylated talazoparib enhances therapeutic window of its combination with temozolomide in Ewing sarcoma.
Vanessa Del Pozo, Andrew J Robles, Shaun D Fontaine, Qianqian Liu, Joel E Michalek

iScience· February 2022

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Attenuation of the Reaction of Michael Acceptors with Biologically Important Nucleophiles.
Brian R Hearn, Shaun D Fontaine, Eric L Schneider, Yannick Kraemer, Gary W Ashley

Bioconjug Chem· April 2021

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A Very Long-Acting PARP Inhibitor Suppresses Cancer Cell Growth in DNA Repair-Deficient Tumor Models.
Shaun D Fontaine, Gary W Ashley, Peter J Houghton, Raushan T Kurmasheva, Morgan Diolaiti

Cancer Res· February 2021

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PET Imaging of the EPR Effect in Tumor Xenografts Using Small 15 nm Diameter Polyethylene Glycols Labeled with Zirconium-89.
Denis R Beckford Vera, Shaun D Fontaine, Henry F VanBrocklin, Brian R Hearn, Ralph Reid

Mol Cancer Ther· February 2020

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Prospective use of the single-mouse experimental design for the evaluation of PLX038A.
Samson Ghilu, Qilin Li, Shaun D Fontaine, Daniel V Santi, Raushan T Kurmasheva

Cancer Chemother Pharmacol· February 2020

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PLX038: a PEGylated prodrug of SN-38 independent of UGT1A1 activity.
Shaun D Fontaine, Angelo D Santi, Ralph Reid, Philip C Smith, Gary W Ashley

Cancer Chemother Pharmacol· January 2020

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Species-specific optimization of PEG~SN-38 prodrug pharmacokinetics and antitumor effects in a triple-negative BRCA1-deficient xenograft.
Shaun D Fontaine, Byron Hann, Ralph Reid, Gary W Ashley, Daniel V Santi

Cancer Chemother Pharmacol· October 2019

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Primary deuterium kinetic isotope effects prolong drug release and polymer biodegradation in a drug delivery system.
Brian R Hearn, Shaun D Fontaine, Samuel J Pfaff, Eric L Schneider, Jeff Henise

J Control Release· May 2018

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A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models.
Benjamin Spangler, Shaun D Fontaine, Yihui Shi, Lidia Sambucetti, Aras N Mattis

J Med Chem· December 2016

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Approach for Half-Life Extension of Small Antibody Fragments That Does Not Affect Tissue Uptake.
Eric L Schneider, Brian R Hearn, Samuel J Pfaff, Shaun D Fontaine, Ralph Reid

Bioconjug Chem· October 2016

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A reactivity-based probe of the intracellular labile ferrous iron pool.
Benjamin Spangler, Charles W Morgan, Shaun D Fontaine, Mark N Vander Wal, Christopher J Chang

Nat Chem Biol· September 2016

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Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response.
Brian R Hearn, Priyadarshini Jaishankar, Carmela Sidrauski, Jordan C Tsai, Punitha Vedantham, Shaun D Fontaine

ChemMedChem· April 2016

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Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria.
Erica M W Lauterwasser, Shaun D Fontaine, Hao Li, Jiri Gut, Kasiram Katneni

ACS Med Chem Lett· November 2015

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High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations.
Bryan T Mott, Richard T Eastman, Rajarshi Guha, Katy S Sherlach, Amila Siriwardana, Shaun D Fontaine

Sci Rep· September 2015

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Drug delivery to the malaria parasite using an arterolane-like scaffold.
Shaun D Fontaine, Benjamin Spangler, Jiri Gut, Erica M W Lauterwasser, Philip J Rosenthal

ChemMedChem· January 2015

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Long-term stabilization of maleimide-thiol conjugates.
Shaun D Fontaine, Ralph Reid, Louise Robinson, Gary W Ashley, Daniel V Santi

Bioconjug Chem· January 2015

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Efficient and stereocontrolled synthesis of 1,2,4-trioxolanes useful for ferrous iron-dependent drug delivery.
Shaun D Fontaine, Antonio G DiPasquale, Adam R Renslo

Org Lett· November 2014

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Synthetic studies on the mycolactone core.
Kwang-Seuk Ko, Matthew D Alexander, Shaun D Fontaine, James E Biggs-Houck, James J La Clair

Org Biomol Chem· November 2010

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