Publications by authors named "Sheila David"

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Designing Programmable Peptide Nucleic Acid-based Nanovaccines for Anticancer Immune Activation.
Yanyu Huang, Cuiqing Huang, Sakshi Pandita, Chon Man Ieong, Yongheng Wang, David Wang, Sheila S David

Small· December 2025

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Crystal structure of MutYX: a novel clusterless adenine DNA glycosylase with a distinct C-terminal domain and 8-oxoguanine recognition sphere.
Carlos H Trasviña-Arenas, Mohammad Hashemian, Melody Malek, Steven Merrill, Andrew J Fisher, Sheila S David

Nucleic Acids Res· November 2025

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Structure, dynamics, and processing of 8oxoG:A in the nucleosome.
Abigayle F Vito, Justin A Ling, Julia C Ferrara, Caleb S Jacques, Natacha Gillet, Sheila S David

bioRxiv· September 2025

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Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repair.
Carlos H Trasviña-Arenas, Upeksha C Dissanayake, Nikole Tamayo, Mohammad Hashemian, Wen-Jen Lin, Sheila S David

Nat Commun· April 2025

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Crystal structure of MutYX: A novel clusterless adenine DNA glycosylase with a distinct C-terminal domain and 8-Oxoguanine recognition sphere.
C H Trasviña-Arenas, Mohammad Hashemian, Melody Malek, Steven Merrill, Andrew J Fisher, Sheila S David

bioRxiv· January 2025

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FSHing for DNA Damage: Key Features of MutY Detection of 8-Oxoguanine:Adenine Mismatches.
Chandrima Majumdar, Merve Demir, Steven R Merrill, Mohammad Hashemian, Sheila S David

Acc Chem Res· April 2024

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Cellular Repair of Synthetic Analogs of Oxidative DNA Damage Reveals a Key Structure-Activity Relationship of the Cancer-Associated MUTYH DNA Repair Glycosylase.
Savannah G Conlon, Cindy Khuu, Carlos H Trasviña-Arenas, Tian Xia, Michelle L Hamm, Sheila S David

ACS Cent Sci· February 2024

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Structural and biochemical insights into NEIL2's preference for abasic sites.
Brian E Eckenroth, Joshua D Bumgarner, Olivia Matsumoto-Elliott, Sheila S David, Sylvie Doublié

Nucleic Acids Res· December 2023

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Structural snapshots of base excision by the cancer-associated variant MutY N146S reveal a retaining mechanism.
Merve Demir, L Peyton Russelburg, Wen-Jen Lin, Carlos H Trasviña-Arenas, Beili Huang, Sheila S David

Nucleic Acids Res· February 2023

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NEIL1 Recoding due to RNA Editing Impacts Lesion-Specific Recognition and Excision.
Elizabeth R Lotsof, Allison E Krajewski, Brittany Anderson-Steele, JohnPatrick Rogers, Lanxin Zhang, Sheila S David

J Am Chem Soc· August 2022

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Structure, function and evolution of the Helix-hairpin-Helix DNA glycosylase superfamily: Piecing together the evolutionary puzzle of DNA base damage repair mechanisms.
C H Trasviña-Arenas, Merve Demir, Wen-Jen Lin, Sheila S David

DNA Repair (Amst)· December 2021

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Single molecule analysis indicates stimulation of MUTYH by UV-DDB through enzyme turnover.
Sunbok Jang, Matthew A Schaich, Cindy Khuu, Brittani L Schnable, Chandrima Majumdar, Sheila S David

Nucleic Acids Res· August 2021

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Structural Insights into the Mechanism of Base Excision by MBD4.
Lakshmi S Pidugu, Hilary Bright, Wen-Jen Lin, Chandrima Majumdar, Robert P Van Ostrand, Sheila S David

J Mol Biol· July 2021

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RNA Editing of the Human DNA Glycosylase NEIL1 Alters Its Removal of 5-Hydroxyuracil Lesions in DNA.
Jongchan Yeo, Elizabeth R Lotsof, Brittany M Anderson-Steele, Sheila S David

Biochemistry· May 2021

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Unique Hydrogen Bonding of Adenine with the Oxidatively Damaged Base 8-Oxoguanine Enables Specific Recognition and Repair by DNA Glycosylase MutY.
Chandrima Majumdar, Paige L McKibbin, Allison E Krajewski, Amelia H Manlove, Jeehiun K Lee, Sheila S David

J Am Chem Soc· December 2020

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Designer Fluorescent Adenines Enable Real-Time Monitoring of MUTYH Activity.
Ru-Yi Zhu, Chandrima Majumdar, Cindy Khuu, Mariarosaria De Rosa, Patricia L Opresko, Sheila S David

ACS Cent Sci· October 2020

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Detection of OG:A Lesion Mispairs by MutY Relies on a Single His Residue and the 2-Amino Group of 8-Oxoguanine.
Andrea J Lee, Chandrima Majumdar, Scott D Kathe, Robert P Van Ostrand, Holly R Vickery, Sheila S David

J Am Chem Soc· August 2020

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An Excimer Clamp for Measuring Damaged-Base Excision by the DNA Repair Enzyme NTH1.
Yong Woong Jun, David L Wilson, Anna M Kietrys, Elizabeth R Lotsof, Savannah G Conlon, Sheila S David

Angew Chem Int Ed Engl· May 2020

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2'-Fluorinated Hydantoins as Chemical Biology Tools for Base Excision Repair Glycosylases.
Sheng Cao, JohnPatrick Rogers, Jongchan Yeo, Brittany Anderson-Steele, Jonathan Ashby, Sheila S David

ACS Chem Biol· April 2020

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The DNA repair enzyme MUTYH potentiates cytotoxicity of the alkylating agent MNNG by interacting with abasic sites.
Alan G Raetz, Douglas M Banda, Xiaoyan Ma, Gege Xu, Anisha N Rajavel, Sheila S David

J Biol Chem· March 2020

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Recognition of DNA adducts by edited and unedited forms of DNA glycosylase NEIL1.
Irina G Minko, Vladimir L Vartanian, Naoto N Tozaki, Erdem Coskun, Sanem Hosbas Coskun, Sheila S David

DNA Repair (Amst)· January 2020

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Structural Basis for Finding OG Lesions and Avoiding Undamaged G by the DNA Glycosylase MutY.
L Peyton Russelburg, Valerie L O'Shea Murray, Merve Demir, Kyle R Knutsen, Sonia L Sehgal, Sheila S David

ACS Chem Biol· January 2020

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When you're strange: Unusual features of the MUTYH glycosylase and implications in cancer.
Alan G Raetz, Sheila S David

DNA Repair (Amst)· August 2019

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Damage sensor role of UV-DDB during base excision repair.
Sunbok Jang, Namrata Kumar, Emily C Beckwitt, Muwen Kong, Elise Fouquerel, Sheila S David

Nat Struct Mol Biol· August 2019

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Evolution of Base Excision Repair in Entamoeba histolytica is shaped by gene loss, gene duplication, and lateral gene transfer.
Carlos H Trasviña-Arenas, Sheila S David, Luis Delaye, Elisa Azuara-Liceaga, Luis G Brieba

DNA Repair (Amst)· April 2019

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