Publications by authors named "Shelli R McAlpine"

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Delivering hydrophilic peptide inhibitors of heat shock protein 70 into cancer cells.
Zifei Han, Shelli R McAlpine, Robert Chapman

Bioorg Chem· May 2022

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De Novo Design, Synthesis, and Mechanistic Evaluation of Short Peptides That Mimic Heat Shock Protein 27 Activity.
Jessica Kho, P Chi Pham, Suhyeon Kwon, Alana Y Huang, Joel P Rivers, Shelli R McAlpine

ACS Med Chem Lett· May 2021

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Using NMR to identify binding regions for N and C-terminal Hsp90 inhibitors using Hsp90 domains.
Jeanette R McConnell, H Jane Dyson, Shelli R McAlpine

RSC Med Chem· March 2021

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Cyclic Peptides as Drugs for Intracellular Targets: The Next Frontier in Peptide Therapeutic Development.
Laura K Buckton, Marwa N Rahimi, Shelli R McAlpine

Chemistry· January 2021

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Delivering bioactive cyclic peptides that target Hsp90 as prodrugs.
Yuantao Huo, Laura K Buckton, Jack L Bennett, Eloise C Smith, Frances L Byrne, Shelli R McAlpine

J Enzyme Inhib Med Chem· December 2019

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C-Terminal HSP90 Inhibitors Block the HIF-1 Hypoxic Response by Degrading HIF-1α through the Oxygen-Dependent Degradation Pathway.
Nalin Kataria, Chloe-Anne Martinez, Bernadette Kerr, Samantha S Zaiter, Monica Morgan, Shelli R McAlpine

Cell Physiol Biochem· December 2019

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Polymer mediated transport of the Hsp90 inhibitor LB76, a polar cyclic peptide, produces an Hsp90 cellular phenotype.
Marwa N Rahimi, Henry G Foster, Shegufta N Farazi, Robert Chapman, Shelli R McAlpine

Chem Commun (Camb)· April 2019

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Designing de Novo Small Molecules That Control Heat Shock Protein 70 (Hsp70) and Heat Shock Organizing Protein (HOP) within the Chaperone Protein-Folding Machinery.
Samantha S Zaiter, Yuantao Huo, Fong Y Tiew, Jason E Gestwicki, Shelli R McAlpine

J Med Chem· January 2019

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Protein-protein inhibitor designed de novo to target the MEEVD region on the C-terminus of Hsp90 and block co-chaperone activity.
Marwa N Rahimi, Shelli R McAlpine

Chem Commun (Camb)· January 2019

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Hsp90 Mediates Membrane Deformation and Exosome Release.
Elsa Lauwers, Yu-Chun Wang, Rodrigo Gallardo, Rob Van der Kant, Emiel Michiels, Shelli R McAlpine

Mol Cell· September 2018

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Improving the Cell Permeability of Polar Cyclic Peptides by Replacing Residues with Alkylated Amino Acids, Asparagines, and d-Amino Acids.
Laura K Buckton, Shelli R McAlpine

Org Lett· February 2018

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Synthesis and Structure-Activity Relationships of Inhibitors That Target the C-Terminal MEEVD on Heat Shock Protein 90.
Marwa N Rahimi, Laura K Buckton, Samantha S Zaiter, Jessica Kho, Vickie Chan, Shelli R McAlpine

ACS Med Chem Lett· February 2018

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RITA Mimics: Synthesis and Mechanistic Evaluation of Asymmetric Linked Trithiazoles.
Adrian L Pietkiewicz, Yuqi Zhang, Marwa N Rahimi, Michael Stramandinoli, Matthew Teusner, Shelli R McAlpine

ACS Med Chem Lett· April 2017

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How Selective are Hsp90 Inhibitors for Cancer Cells over Normal Cells?
Yao Wang, Yen Chin Koay, Shelli R McAlpine

ChemMedChem· March 2017

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Redefining the Phenotype of Heat Shock Protein 90 (Hsp90) Inhibitors.
Yao Wang, Yen Chin Koay, Shelli R McAlpine

Chemistry· February 2017

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A Novel Class of Hsp90 C-Terminal Modulators Have Pre-Clinical Efficacy in Prostate Tumor Cells Without Induction of a Heat Shock Response.
Heather K Armstrong, Yen Chin Koay, Swati Irani, Rajdeep Das, Zeyad D Nassar, Shelli R McAlpine

Prostate· December 2016

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Reinventing Hsp90 Inhibitors: Blocking C-Terminal Binding Events to Hsp90 by Using Dimerized Inhibitors.
Yen Chin Koay, Hendra Wahyudi, Shelli R McAlpine

Chemistry· December 2016

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Hitting a Moving Target: How Does an N-Methyl Group Impact Biological Activity?
Yen Chin Koay, Nicole L Richardson, Samantha S Zaiter, Jessica Kho, Sheena Y Nguyen, Shelli R McAlpine

ChemMedChem· April 2016

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Heat-shock protein 90 inhibitors: will they ever succeed as chemotherapeutics?
Yao Wang, Shelli R McAlpine

Future Med Chem· November 2015

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Synthesis of the Natural Product Marthiapeptide A.
Yuqi Zhang, Md Amirul Islam, Shelli R McAlpine

Org Lett· November 2015

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Regulating the master regulator: Controlling heat shock factor 1 as a chemotherapy approach.
Jeanette R McConnell, Laura K Buckton, Shelli R McAlpine

Bioorg Med Chem Lett· September 2015

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Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity.
Elisabeth K Malle, Nathan W Zammit, Stacey N Walters, Yen Chin Koay, Jianmin Wu, Shelli R McAlpine

J Exp Med· July 2015

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Thioimidazoline based compounds reverse glucocorticoid resistance in human acute lymphoblastic leukemia xenografts.
Cara E Toscan, Marwa Rahimi, Mohan Bhadbhade, Russell Pickford, Shelli R McAlpine

Org Biomol Chem· June 2015

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Predicting the unpredictable: Recent structure-activity studies on peptide-based macrocycles.
Hendra Wahyudi, Shelli R McAlpine

Bioorg Chem· June 2015

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The fungal natural product (1S,3S)-austrocortirubin induces DNA damage in HCT116 cells via a mechanism unique from other DNA damaging agents.
Yao Wang, Md Amirul Islam, Rohan A Davis, Shelli R McAlpine

Bioorg Med Chem Lett· January 2015

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