Publications by authors named "Shengyong Yang"

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Small molecules in targeted cancer therapy: advances, challenges, and future perspectives.
Lei Zhong, Yueshan Li, Liang Xiong, Wenjing Wang, Ming Wu, Ting Yuan, Wei Yang, Chenyu Tian, Zhuang Miao, Tianqi Wang

Signal Transduct Target Ther· May 2021

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Author Correction: An orally available M/TMPRSS2 bispecific inhibitor with potent anti-coronavirus efficacy in vivo.
Huiping Shuai, Jingxin Qiao, Chaemin Yoon, Guo Zhang, Yuxin Hou, Yang Wang, Shengyong Yang

Nat Commun· December 2025

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Discovery and structure-activity relationship studies of 3-pyridazinesulfonyl derivatives as a new class of inhibitors against NLRP3 inflammasome-dependent pyroptosis.
Jinshan Nan, Shanmian Ji, Nenghua Zhou, Yan Jiao, Yun Zhang, Shengyong Yang

Eur J Med Chem· October 2025

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Azapeptide-Based SARS-CoV-2 Main Protease Inhibitors: Design, Synthesis, Enzyme Inhibition, Structural Determination, and Antiviral Activity.
Philipp Flury, Jyoti Vishwakarma, Katharina Sylvester, Nobuyo Higashi-Kuwata, Agnieszka K Dabrowska, Shengyong Yang

J Med Chem· September 2025

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ADAR1-mediated RNA editing in breast cancer: molecular mechanisms and therapeutic implications.
Si-Yu Chen, Si-Ying Chen, Shu Yang, Yi Li, Sheng-Yong Yang

Med Oncol· August 2025

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Discovery of 4-((quinolin-8-ylthio)methyl)benzamide derivatives as a new class of SARS-CoV-2 nsp13 inhibitors.
Danchen Fan, Yuanting Huang, Rui Yao, Guo Zhang, Shengyong Yang

Bioorg Med Chem Lett· July 2025

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Transcription factor KLF5 regulates MsrB1 to promote colorectal cancer progression by inhibiting ferroptosis through β-catenin.
Zhengdan Gao, Shengyong Yang, Shanshan Jiang, Qian Wu, Yi Jia, Jun Yang

Free Radic Biol Med· July 2025

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EZH2 loss promotes gastric squamous cell carcinoma.
Mengsha Zhang, Ailing Zhong, Hongyu Liu, Lei Zhao, Yingjie Wang, Jingyang Cai, Yang Yang, Chan Yang, Shengyong Yang

Nat Commun· July 2025

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An orally available M/TMPRSS2 bispecific inhibitor with potent anti-coronavirus efficacy in vivo.
Huiping Shuai, Jingxin Qiao, Chaemin Yoon, Guo Zhang, Yuxin Hou, Yang Wang, Shengyong Yang

Nat Commun· July 2025

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Acquired resistance to immunotherapy by physical barriers with cancer cell-expressing collagens in non-small cell lung cancer.
Manli Wang, Yiyun Wang, Xiangyu Pan, Bo Wang, Yuying Wang, Yang Yang, Yanyang Liu, Shengyong Yang

Proc Natl Acad Sci U S A· June 2025

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Biomedical data and AI.
Hao Xu, Shibo Zhou, Zefeng Zhu, Vincenzo Vitelli, Liangyi Chen, Ning Yang, Shengyong Yang, Yang-Yu Liu, Ge Yang

Sci China Life Sci· May 2025

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Correction to: TIFA suppresses hepatocellular carcinoma progression via MALT1-dependent and -independent signaling pathways.
Wenzhi Shen, Renle Du, Jun Li, Xiaohe Luo, Shuangtao Zhao, Shengyong Yang

Signal Transduct Target Ther· March 2025

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Design, Synthesis, and Unprecedented Interactions of Covalent Dipeptide-Based Inhibitors of SARS-CoV-2 Main Protease and Its Variants Displaying Potent Antiviral Activity.
Philipp Flury, Nadine Krüger, Katharina Sylvester, Julian Breidenbach, Ghazl Al Hamwi, Shengyong Yang

J Med Chem· February 2025

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Discovery of phenazine derivatives as a new class of non-classical ferroptosis inhibitors and efficacy evaluation on a mouse model of liver injury.
Yunjie Wu, Lu Yang, Jing You, Chenyu Tian, Shengyong Yang

Eur J Med Chem· January 2025

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Discovery and structure-activity relationship study of nicotinamide derivatives as DNA demethylase ALKBH2 inhibitors.
Ke Xu, Feng Li, Liang Xiong, Yinping Guo, Jian Zhang, Yuyang Wang, Shengyong Yang

Eur J Med Chem· January 2025

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Artificial intelligence in drug development.
Kang Zhang, Xin Yang, Yifei Wang, Yunfang Yu, Niu Huang, Shengyong Yang

Nat Med· January 2025

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An orally available Mpro/TMPRSS2 bispecific inhibitor with potent anti-coronavirus efficacy in vivo.
Hin Chu, Huiping Shuai, Jingxin Qiao, Chaemin Yoon, Guo Zhang, Yang Wang, Shengyong Yang

Res Sq· November 2024

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Predicting transcriptional responses to novel chemical perturbations using deep generative model for drug discovery.
Xiaoning Qi, Lianhe Zhao, Chenyu Tian, Yueyue Li, Zhen-Lin Chen, Shengyong Yang

Nat Commun· October 2024

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Loss of ADAR1 induces ferroptosis of breast cancer cells.
Chuan Yin, Meng-Meng Zhang, Guo-Liang Wang, Xiao-Yan Deng, Zeng Tu, Sheng-Yong Yang

Cell Signal· September 2024

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Structural Optimization and Structure-Activity Relationship of 1-Pyrazole-4-carboxylic Acid Derivatives as DNA 6mA Demethylase ALKBH1 Inhibitors and Their Antigastric Cancer Activity.
Feng Li, Liang Xiong, Jian Zhang, Yinping Guo, Ke Xu, Yuyang Wang, Shengyong Yang

J Med Chem· September 2024

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KIAA0753 enhances osteoblast differentiation suppressed by diabetes.
Mengxue Li, Yongqin Wang, Xiangmei Wu, Quanmei Chen, Jianguo Huang, Shengyong Yang

J Cell Mol Med· September 2024

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Inhibition of METTL3 Alleviates NLRP3 Inflammasome Activation via Increasing Ubiquitination of NEK7.
Xinyi Zhou, Xiaoyu Yang, Shenzhen Huang, Guifeng Lin, Kexin Lei, Shengyong Yang

Adv Sci (Weinh)· July 2024

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Entropy drives the ligand recognition in G-protein-coupled receptor subtypes.
Xin Yang, Pei Zhou, Siyuan Shen, Qian Hu, Chenyu Tian, Zhiqian Yang, Yangli Zhou, Shengyong Yang

Proc Natl Acad Sci U S A· July 2024

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Identification of a new class of activators of the Hippo pathway with antitumor activity in vitro and in vivo.
Guifeng Lin, Anjie Xia, Jingxin Qiao, Hailin Zhang, Pei Chen, Shengyong Yang

Biochem Pharmacol· June 2024

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Structure-based identification of a G protein-biased allosteric modulator of cannabinoid receptor CB1.
Siyuan Shen, Chao Wu, Guifeng Lin, Xin Yang, Yangli Zhou, Zhiqian Yang, Shengyong Yang

Proc Natl Acad Sci U S A· June 2024

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Discovery of a Potent and Cell-Active Inhibitor of DNA 6mA Demethylase ALKBH1.
Liang Xiong, Feng Li, Yinping Guo, Jian Zhang, Ke Xu, Shengyong Yang

J Am Chem Soc· March 2024

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