Publications by authors named "Sheo B Singh"

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Insights into the Biosynthesis of Kibdelomycin and Amycolamicin from Comparative Biosynthetic Gene Cluster Analysis and Precursor Incorporation Studies.
Marina Sánchez-Hidalgo, José Miguel Quesada, Daniel Oves-Costales, Jonah Fine, Jesús Martín, Sheo B Singh

J Nat Prod· August 2025

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Antibacterial and mechanism of action studies of boxazomycin A.
Sheo B Singh, James Occi, John Ondeyka, John F Barrett, Prakash Masurekar

J Antibiot (Tokyo)· October 2024

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History and Prospects of Drug Discovery and Development Collaboration between Industry and Academia.
Sheo B Singh, Gary E Martin, Brian McKittrick, Jonathan Crowther, Howard Fraenkel

J Nat Prod· April 2024

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Discovery, synthesis, activities, structure-activity relationships, and clinical development of combretastatins and analogs as anticancer drugs. A comprehensive review.
Sheo B Singh

Nat Prod Rep· February 2024

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Structure activity relationship of N-1 substituted 1,5-naphthyrid-2-one analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-9).
Sheo B Singh, Christopher M Tan, David Kaelin, Peter T Meinke, Lynn Miesel

Bioorg Med Chem Lett· November 2022

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Nocathiacin, Thiazomycin, and Polar Analogs Are Highly Effective Agents against Toxigenic .
Sheo B Singh, Lynn Miesel, Susanne Kramer, Libo Xu, Fangbio Li

J Nat Prod· April 2022

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Discovery and Development of Dolastatin 10-Derived Antibody Drug Conjugate Anticancer Drugs.
Sheo B Singh

J Nat Prod· March 2022

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Rapid, Selective, and Sensitive Method for Semitargeted Discovery of Congeneric Natural Products by Liquid Chromatography Tandem Mass Spectrometry.
Kithsiri B Herath, Stephen F Previs, Thomas P Roddy, Athula B Attygalle, Ignacio González, Sheo B Singh

J Nat Prod· March 2021

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Using [H]water to quantify the contribution of de novo palmitate synthesis in plasma: enabling back-to-back studies.
Stephen F Previs, Kithsiri Herath, Andrea R Nawrocki, Carlos G Rodriguez, Deborah Slipetz, Sheo B Singh

Am J Physiol Endocrinol Metab· July 2018

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Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis.
Sheo B Singh, Joshua Odingo, Mai A Bailey, Bjorn Sunde, Aaron Korkegian

BMC Res Notes· June 2018

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The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys.
Sheo B Singh, Ling Kang, Andrea R Nawrocki, Dan Zhou, Margaret Wu

PLoS One· June 2017

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What is an "ideal" antibiotic? Discovery challenges and path forward.
Sheo B Singh, Katherine Young, Lynn L Silver

Biochem Pharmacol· June 2017

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Thiazomycin, nocathiacin and analogs show strong activity against clinical strains of drug-resistant Mycobacterium tuberculosis.
Sheo B Singh, Libo Xu, Peter T Meinke, Natalia Kurepina, Barry N Kreiswirth

J Antibiot (Tokyo)· May 2017

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Correction: The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys.
Sheo B Singh, Ling Kang, Andrea R Nawrocki, Dan Zhou, Margaret Wu

PLoS One· January 2017

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Discovery and development of kibdelomycin, a new class of broad-spectrum antibiotics targeting the clinically proven bacterial type II topoisomerase.
Sheo B Singh

Bioorg Med Chem· December 2016

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In Vitro and In Vivo Characterization of the Novel Oxabicyclooctane-Linked Bacterial Topoisomerase Inhibitor AM-8722, a Selective, Potent Inhibitor of Bacterial DNA Gyrase.
Christopher M Tan, Charles J Gill, Jin Wu, Nathalie Toussaint, Jingjun Yin, Sheo B Singh

Antimicrob Agents Chemother· August 2016

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Kibdelomycin is a bactericidal broad-spectrum aerobic antibacterial agent.
Sheo B Singh, Priya Dayananth, Carl J Balibar, Charles G Garlisi, Jun Lu

Antimicrob Agents Chemother· February 2016

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Structure activity relationship of pyridoxazinone substituted RHS analogs of oxabicyclooctane-linked 1,5-naphthyridinyl novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-6).
Sheo B Singh, David E Kaelin, Jin Wu, Lynn Miesel, Christopher M Tan

Bioorg Med Chem Lett· September 2015

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Structure activity relationship of C-2 ether substituted 1,5-naphthyridine analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-5).
Sheo B Singh, David E Kaelin, Peter T Meinke, Jin Wu, Lynn Miesel

Bioorg Med Chem Lett· September 2015

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Structure activity relationship of substituted 1,5-naphthyridine analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-4).
Sheo B Singh, David E Kaelin, Jin Wu, Lynn Miesel, Christopher M Tan

Bioorg Med Chem Lett· June 2015

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Hydroxy tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of RHS moiety (Part-3).
Sheo B Singh, David E Kaelin, Jin Wu, Lynn Miesel, Christopher M Tan

Bioorg Med Chem Lett· June 2015

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Tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of left-hand-side moiety (Part-2).
Sheo B Singh, David E Kaelin, Jin Wu, Lynn Miesel, Christopher M Tan

Bioorg Med Chem Lett· May 2015

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Cyclic colisporifungin and linear cavinafungins, antifungal lipopeptides isolated from Colispora cavincola.
Francisco Javier Ortíz-López, Maria Cândida Monteiro, Víctor González-Menéndez, José R Tormo, Olga Genilloud, Sheo B Singh

J Nat Prod· March 2015

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Design, synthesis, structure-function relationship, bioconversion, and pharmacokinetic evaluation of ertapenem prodrugs.
Sheo B Singh, Diane Rindgen, Prudence Bradley, Takao Suzuki, Nengxue Wang

J Med Chem· October 2014

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Confronting the challenges of discovery of novel antibacterial agents.
Sheo B Singh

Bioorg Med Chem Lett· August 2014

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