Publications by authors named "Shigeru Ohta"

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[Verification of Pharmaceutical Education System Reform].
Shigeru Ohta

Yakugaku Zasshi· September 2024

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Virtual Reality Images of the Home Are Useful for Patients With Hospital-Based Palliative Care: Prospective Observational Study With Analysis by Text Mining.
Tomoyo Mukai, Yoshi Tsukiyama, Shinobu Yamada, Akinori Nishikawa, Shinya Hayami, Shigeru Ohta

Palliat Med Rep· August 2023

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Methylmercury Decreases AMPA Receptor Subunit GluA2 Levels in Cultured Rat Cortical Neurons.
Keishi Ishida, Kazuki Takeda, Yuki Takehara, Tomoki Takabayashi, Masatsugu Miyara, Shigeru Ohta

Biol Pharm Bull· February 2023

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Xanthine oxidase and aldehyde oxidase contribute to allopurinol metabolism in rats.
Yoshitaka Tayama, Kazumi Sugihara, Seigo Sanoh, Katsushi Miyake, Shigeyuki Kitamura, Shigeru Ohta

J Pharm Health Care Sci· December 2022

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Improved Predictability of Hepatic Clearance with Optimal pH for Acyl-Glucuronidation in Liver Microsomes.
Tohru Mizutare, Seigo Sanoh, Takushi Kanazu, Shigeru Ohta, Yaichiro Kotake

J Pharm Sci· November 2022

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Assessment of metabolic activation of felbamate in chimeric mice with humanized liver in combination with in vitro metabolic assays.
Koya Sato, Seigo Sanoh, Yuji Ishida, Chise Tateno, Shigeru Ohta

J Toxicol Sci· July 2022

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Involvement of aldehyde oxidase in the metabolism of aromatic and aliphatic aldehyde-odorants in the mouse olfactory epithelium.
Naoki Takaoka, Seigo Sanoh, Shigeru Ohta, Mariam Esmaeeli, Silke Leimkühler

Arch Biochem Biophys· January 2022

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Predictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptide (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: integration with hepatic drug metabolism.
Seigo Sanoh, Yoichi Naritomi, Satoshi Kitamura, Akihiko Shinagawa, Masakazu Kakuni, Shigeru Ohta

Xenobiotica· November 2020

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Amiodarone bioconcentration and suppression of metamorphosis in Xenopus.
Seigo Sanoh, Hideki Hanada, Keiko Kashiwagi, Tsukasa Mori, Naoko Goto-Inoue, Shigeru Ohta

Aquat Toxicol· November 2020

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Changes in Bile Acid Concentrations after Administration of Ketoconazole or Rifampicin to Chimeric Mice with Humanized Liver.
Seigo Sanoh, Yuka Tamura, Chieri Fujino, Go Sugahara, Yasumi Yoshizane, Shigeru Ohta

Biol Pharm Bull· January 2020

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Comparative study of the effect of 17 parabens on PXR-, CAR- and PPARα-mediated transcriptional activation.
Chieri Fujino, Yoko Watanabe, Seigo Sanoh, Shoko Hattori, Hiroyuki Nakajima, Shigeru Ohta

Food Chem Toxicol· November 2019

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Activation of PXR, CAR and PPARα by pyrethroid pesticides and the effect of metabolism by rat liver microsomes.
Chieri Fujino, Yoko Watanabe, Seigo Sanoh, Hiroyuki Nakajima, Naoto Uramaru, Shigeru Ohta

Heliyon· September 2019

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Utility of Chimeric Mice with Humanized Liver for Predicting Human Pharmacokinetics in Drug Discovery: Comparison with in Vitro-in Vivo Extrapolation and Allometric Scaling.
Yoichi Naritomi, Seigo Sanoh, Shigeru Ohta

Biol Pharm Bull· July 2019

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Coordinated cytochrome P450 expression in mouse liver and intestine under different dietary conditions during liver regeneration after partial hepatectomy.
Chieri Fujino, Seigo Sanoh, Chise Tateno, Shigeru Ohta, Yaichiro Kotake

Toxicol Appl Pharmacol· May 2019

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[Contribution of chimeric mice with a humanized liver to the evaluation of pharmacology, toxicity, and pharmacokinetics in drug discovery and development].
Seigo Sanoh, Shigeru Ohta

Nihon Yakurigaku Zasshi· February 2019

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Inhibition of cytochrome P450 3A protein degradation and subsequent increase in enzymatic activity through p38 MAPK activation by acetaminophen and salicylate derivatives.
Yuya Ohtsuki, Seigo Sanoh, Masataka Santoh, Yoko Ejiri, Shigeru Ohta

Biochem Biophys Res Commun· January 2019

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Inhibitory effects of drugs on the metabolic activity of mouse and human aldehyde oxidases and influence on drug-drug interactions.
Naoki Takaoka, Seigo Sanoh, Katsuhiro Okuda, Yaichiro Kotake, Go Sugahara, Shigeru Ohta

Biochem Pharmacol· August 2018

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Comparison of Drug Metabolism and Its Related Hepatotoxic Effects in HepaRG, Cryopreserved Human Hepatocytes, and HepG2 Cell Cultures.
Yuichi Yokoyama, Yoshifumi Sasaki, Natsuko Terasaki, Taku Kawataki, Koji Takekawa, Shigeru Ohta

Biol Pharm Bull· May 2018

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Chimeric mice with humanized liver: Application in drug metabolism and pharmacokinetics studies for drug discovery.
Yoichi Naritomi, Seigo Sanoh, Shigeru Ohta

Drug Metab Pharmacokinet· February 2018

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Tributyltin induces epigenetic changes and decreases the expression of nuclear respiratory factor-1.
Saki Hanaoka, Keishi Ishida, Saki Tanaka, Shuichiro Sakamoto, Katsuhiro Okuda, Shigeru Ohta

Metallomics· February 2018

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Carbofuran causes neuronal vulnerability to glutamate by decreasing GluA2 protein levels in rat primary cortical neurons.
Kanae Umeda, Masatsugu Miyara, Keishi Ishida, Seigo Sanoh, Shigeru Ohta

Arch Toxicol· January 2018

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Assessment of amiodarone-induced phospholipidosis in chimeric mice with a humanized liver.
Seigo Sanoh, Yuto Yamachika, Yuka Tamura, Yaichiro Kotake, Yasumi Yoshizane, Shigeru Ohta

J Toxicol Sci· January 2018

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Developmental changes in drug-metabolizing enzyme expression during metamorphosis of Xenopus tropicalis.
Junpei Mori, Seigo Sanoh, Keiko Kashiwagi, Hideki Hanada, Mitsuki Shigeta, Shigeru Ohta

J Toxicol Sci· January 2018

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Purification of monoclonal antibodies entirely in flow-through mode.
Tsuyoshi Yamada, Koichi Yamamoto, Takashi Ishihara, Shigeru Ohta

J Chromatogr B Analyt Technol Biomed Life Sci· September 2017

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Low-Concentration Tributyltin Decreases GluR2 Expression via Nuclear Respiratory Factor-1 Inhibition.
Keishi Ishida, Kaori Aoki, Tomoko Takishita, Masatsugu Miyara, Shuichiro Sakamoto, Shigeru Ohta

Int J Mol Sci· August 2017

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