Publications by authors named "Shih-Jen Liu"

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Lipid nanoparticle-formulated DNA acts as a potent immune modulator for cancer immunotherapy through interferon signaling pathways.
Chen-Yi Chiang, Ming-Shu Hsieh, Mei-Yu Chen, Yu-Wen Tsai, Chang-Ling Lin, Shih-Jen Liu

Theranostics· December 2025

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Advances in nucleic acid-based cancer vaccines.
Hung-Chun Liao, Shih-Jen Liu

J Biomed Sci· January 2025

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Boosting DNA vaccine power by lipid nanoparticles surface engineered with amphiphilic bioresorbable copolymer.
Chung-Hsiang Yang, Kuan-Yin Shen, Hui-Min Ho, Chiung-Yi Huang, Yu-Jhen Cheng, Shih-Jen Liu

Mol Ther Nucleic Acids· September 2024

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ADAM9 drives the immunosuppressive microenvironment by cholesterol biosynthesis-mediated activation of IL6-STAT3 signaling for lung tumor progression.
Jing-Pei Liu, Kuan-Yin Shen, Wei-Chung Cheng, Wei-Chao Chang, Chih-Ying Hsieh, Shih-Jen Liu

Am J Cancer Res· April 2024

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Lipid nanoparticle-encapsulated DNA vaccine robustly induce superior immune responses to the mRNA vaccine in Syrian hamsters.
Hung-Chun Liao, Kuan-Yin Shen, Chung-Hsiang Yang, Fang-Feng Chiu, Chen-Yi Chiang, Shih-Jen Liu

Mol Ther Methods Clin Dev· March 2024

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Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy.
Yu-Kai Huang, Wei-Chung Cheng, Ting-Ting Kuo, Juan-Cheng Yang, Yang-Chang Wu, Shih-Jen Liu

Nat Cancer· March 2024

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SARS-CoV-2 spike-FLIPr fusion protein plus lipidated FLIPr protects against various SARS-CoV-2 variants in hamsters.
Ming-Shu Hsieh, Chia-Wei Hsu, Hung-Chun Liao, Chang-Ling Lin, Chen-Yi Chiang, Shih-Jen Liu

J Virol· February 2024

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A TLR9 agonist synergistically enhances protective immunity induced by an Alum-adjuvanted H7N9 inactivated whole-virion vaccine.
Tsai-Teng Tzeng, Kit Man Chai, I-Hua Chen, Ray-Yuan Chang, Jen-Ron Chiang, Shih-Jen Liu

Emerg Microbes Infect· December 2023

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A broad-spectrum pneumococcal vaccine induces mucosal immunity and protects against lethal challenge.
Fang-Feng Chiu, Ling-Ling Tu, Wangxue Chen, Hongyan Zhou, Bing-Sin Liu, Shih-Jen Liu

Emerg Microbes Infect· December 2023

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Humoral and cellular immunity in three different types of COVID-19 vaccines against SARS-CoV-2 variants in a real-world data analysis.
Ying-Chyi Song, Shih-Jen Liu, Hui-Ju Lee, Hung-Chun Liao, Chuan-Teng Liu

J Microbiol Immunol Infect· August 2023

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Co-delivery of a trimeric spike DNA and protein vaccine with aluminum hydroxide enhanced Th1-dominant humoral and cellular immunity against SARS-CoV-2.
Hung-Chun Liao, Min-Syuan Huang, Fang-Feng Chiu, Kit Man Chai, Ching-Len Liao, Shih-Jen Liu

J Med Virol· August 2023

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Recombinant lipidated FLIPr effectively enhances mucosal and systemic immune responses for various vaccine types.
Ming-Shu Hsieh, Mei-Yu Chen, Chia-Wei Hsu, Yu-Wen Tsai, Fang-Feng Chiu, Shih-Jen Liu

NPJ Vaccines· June 2023

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TLR9 and STING agonists cooperatively boost the immune response to SARS-CoV-2 RBD vaccine through an increased germinal center B cell response and reshaped T helper responses.
Jing-Xing Yang, Jen-Chih Tseng, Chih-Feng Tien, Chia-Yin Lee, Yi-Ling Liu, Shih-Jen Liu

Int J Biol Sci· June 2023

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Omicron-specific mRNA vaccine induced cross-protective immunity against ancestral SARS-CoV-2 infection with low neutralizing antibodies.
Kuan-Yin Shen, Chung-Hsiang Yang, Chiung-Tong Chen, Hui-Min Ho, Fang-Feng Chiu, Shih-Jen Liu

J Med Virol· January 2023

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Correction: DNA vaccination induced protective immunity against SARS CoV-2 infection in hamsterss.
Kit Man Chai, Tsai-Teng Tzeng, Kuan-Yin Shen, Hung-Chun Liao, Jhe-Jhih Lin, Shih-Jen Liu

PLoS Negl Trop Dis· January 2023

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A flexible liposomal polymer complex as a platform of specific and regulable immune regulation for individual cancer immunotherapy.
Chia-Hung Chen, Tzu-Han Weng, Hsiao-Hsuan Huang, Ling-Ya Huang, Kai-Yao Huang, Shih-Jen Liu

J Exp Clin Cancer Res· January 2023

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Formulation of SARS-CoV-2 Spike Protein with CpG Oligodeoxynucleotides and Squalene Nanoparticles Modulates Immunological Aspects Following Intranasal Delivery.
Hui-Min Ho, Chiung-Yi Huang, Chung-Hsiang Yang, Shih-Jen Liu, Hsin-Wei Chen

Pharmaceutics· November 2022

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Measurements of Anti-SARS-CoV-2 Antibody Levels after Vaccination Using a SH-SAW Biosensor.
Chia-Hsuan Cheng, Yu-Chi Peng, Shu-Min Lin, Hiromi Yatsuda, Szu-Heng Liu, Shih-Jen Liu

Biosensors (Basel)· August 2022

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A DNA vaccine candidate delivered by an electroacupuncture machine provides protective immunity against SARS-CoV-2 infection.
Tsai-Teng Tzeng, Kit Man Chai, Kuan-Yin Shen, Chia-Yi Yu, Shiu-Ju Yang, Shih-Jen Liu

NPJ Vaccines· June 2022

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Induction of high affinity monoclonal antibodies against SARS-CoV-2 variant infection using a DNA prime-protein boost strategy.
Chen-Yi Chiang, Mei-Yu Chen, Chia-Wei Hsu, Chia-Yeh Liu, Yu-Wen Tsai, Shih-Jen Liu

J Biomed Sci· June 2022

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Furin and TMPRSS2 Resistant Spike Induces Robust Humoral and Cellular Immunity Against SARS-CoV-2 Lethal Infection.
Jhe-Jhih Lin, Chih-Feng Tien, Yi-Ping Kuo, En-Ju Lin, Wei-Hsiang Tsai, Shih-Jen Liu

Front Immunol· May 2022

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Monoclonal antibody targeting the conserved region of the SARS-CoV-2 spike protein to overcome viral variants.
Wan-Ling Wu, Chen-Yi Chiang, Szu-Chia Lai, Chia-Yi Yu, Yu-Ling Huang, Shih-Jen Liu

JCI Insight· April 2022

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Low-Dose SARS-CoV-2 S-Trimer with an Emulsion Adjuvant Induced Th1-Biased Protective Immunity.
Hung-Chun Liao, Wan-Ling Wu, Chen-Yi Chiang, Min-Syuan Huang, Kuan-Yin Shen, Shih-Jen Liu

Int J Mol Sci· April 2022

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Intranasal Vaccination With Recombinant Antigen-FLIPr Fusion Protein Alone Induces Long-Lasting Systemic Antibody Responses and Broad T Cell Responses.
Ming-Shu Hsieh, Chia-Wei Hsu, Ling-Ling Tu, Kit Man Chai, Li-Lu Yu, Shih-Jen Liu

Front Immunol· January 2022

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A Novel Rapid Test to Detect Anti-SARS-CoV-2 N Protein IgG Based on Shear Horizontal Surface Acoustic Wave (SH-SAW).
Yu-Chi Peng, Chia-Hsuan Cheng, Hiromi Yatsuda, Szu-Heng Liu, Shih-Jen Liu

Diagnostics (Basel)· October 2021

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