Publications by authors named "Shin Iimura"

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Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity.
Toru Taniguchi, Hiroaki Inagaki, Daichi Baba, Isao Yasumatsu, Akiko Toyota, Shin Iimura

ACS Med Chem Lett· May 2019

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A novel inhibitor stabilizes the inactive conformation of MAPK-interacting kinase 1.
Yumi Matsui, Isao Yasumatsu, Ken Ichi Yoshida, Shin Iimura, Yutaka Ikeno

Acta Crystallogr F Struct Biol Commun· March 2018

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Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor.
Jean-Marc Lapierre, Sudharshan Eathiraj, David Vensel, Yanbin Liu, Cathy O Bull, Shin Iimura

J Med Chem· July 2016

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A novel inhibitor of I-kappaB kinase beta ameliorates experimental arthritis through downregulation of proinflammatory cytokines in arthritic joints.
Shinji Tanaka, Tadashi Toki, Mika Yokoyama, Hiroki Shimizu, Tomonori Yamasaki, Shin Iimura

Biol Pharm Bull· August 2014

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A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid.
Masaki Setoguchi, Shin Iimura, Yuuichi Sugimoto, Yoshiyuki Yoneda, Jun Chiba

Bioorg Med Chem· January 2013

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Identification of trans-4-[1-[[7-fluoro-2-(1-methyl-3-indolyl)-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid as a potent, orally active VLA-4 antagonist.
Masaki Setoguchi, Shin Iimura, Yuuichi Sugimoto, Yoshiyuki Yoneda, Jun Chiba

Bioorg Med Chem· February 2012

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Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 3: exploration of effective compounds in arthritis models.
Hiroki Shimizu, Tomonori Yamasaki, Yoshiyuki Yoneda, Fumihito Muro, Tomoaki Hamada, Shin Iimura

Bioorg Med Chem Lett· August 2011

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Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 2: improvement of potency in vitro and in vivo.
Hiroki Shimizu, Isao Yasumatsu, Tomoaki Hamada, Yoshiyuki Yoneda, Tomonori Yamasaki, Shin Iimura

Bioorg Med Chem Lett· February 2011

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Discovery of imidazo[1,2-b]pyridazine derivatives as IKKbeta inhibitors. Part 1: Hit-to-lead study and structure-activity relationship.
Hiroki Shimizu, Shinji Tanaka, Tadashi Toki, Isao Yasumatsu, Toshihiko Akimoto, Shin Iimura

Bioorg Med Chem Lett· September 2010

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Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist.
Fumihito Muro, Shin Iimura, Yuuichi Sugimoto, Yoshiyuki Yoneda, Jun Chiba

J Med Chem· December 2009

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A novel and potent VLA-4 antagonist based on trans-4-substituted cyclohexanecarboxylic acid.
Fumihito Muro, Shin Iimura, Yoshiyuki Yoneda, Jun Chiba, Toshiyuki Watanabe

Bioorg Med Chem· February 2009

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Identification of 4-[1-[3-chloro-4-[N'-(5-fluoro-2-methylphenyl)ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]benzoic acid as a potent, orally active VLA-4 antagonist.
Fumihito Muro, Shin Iimura, Yoshiyuki Yoneda, Jun Chiba, Toshiyuki Watanabe

Bioorg Med Chem· December 2008

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Synthesis and biological evaluation of benzoic acid derivatives as potent, orally active VLA-4 antagonists.
Jun Chiba, Shin Iimura, Yoshiyuki Yoneda, Toshiyuki Watanabe, Fumito Muro

Bioorg Med Chem· February 2007

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4-(Pyrrolidinyl)methoxybenzoic acid derivatives as a potent, orally active VLA-4 antagonist.
Jun Chiba, Shin Iimura, Yoshiyuki Yoneda, Yuichi Sugimoto, Takao Horiuchi

Chem Pharm Bull (Tokyo)· November 2006

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Enantioselective total synthesis of guanacastepene N using an uncommon 7-endo Heck cyclization as a pivotal step.
Shin Iimura, Larry E Overman, Ralph Paulini, Armen Zakarian

J Am Chem Soc· October 2006

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New highly active taxoids from 9beta-dihydrobaccatin-9,10-acetals. Part 2.
Takashi Ishiyama, Shin Iimura, Toshiharu Yoshino, Jun Chiba, Kouichi Uoto

Bioorg Med Chem Lett· October 2002

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New highly active taxoids from 9 beta-dihydrobaccatin-9,10-acetals.
Takashi Ishiyama, Shin Iimura, Satoru Ohsuki, Kouichi Uoto, Hirofumi Terasawa

Bioorg Med Chem Lett· April 2002

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Studies on Steric and Electronic Control of 2'-3' Phosphoryl Migration in 2'-Phosphorylated Uridine Derivatives and Its Application to the Synthesis of 2'-Phosphorylated Oligouridylates.
Mitsuo Sekine, Hiroyuki Tsuruoka, Shin Iimura, Hiroshi Kusuoku, Takeshi Wada

J Org Chem· June 1996

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