Publications by authors named "Shingo Dan"

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Antitumor effect of BC12-3 on multiple myeloma via proteasome inhibition.
Huiying Li, Geng Jia, Naixin Zhang, Rui Fan, Wenqing Jia, Shingo Dan

Med Oncol· June 2025

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SLFN11-mediated ribosome biogenesis impairment induces TP53-independent apoptosis.
Akane Ogawa, Keiichi Izumikawa, Sota Tate, Sho Isoyama, Masaru Mori, Shingo Dan

Mol Cell· March 2025

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Metabolically inducing defects in DNA repair sensitizes -wild-type cancer cells to replication stress.
Kenji Watanabe, Tatsuro Yamamoto, Tomoko Fujita, Shinjiro Hino, Yuko Hino, Shingo Dan

Sci Signal· November 2024

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Methyl scanning approach for enhancing the biological activity of the linear peptidic natural product, efrapeptin C.
Yuanqi Lin, Hiroaki Itoh, Shingo Dan, Masayuki Inoue

Chem Sci· November 2024

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Cytochrome P450 2J2 is required for the natural compound austocystin D to elicit cancer cell toxicity.
Yukiko Kojima, Saki Fujieda, Liya Zhou, Masahiro Takikawa, Kouji Kuramochi, Shingo Dan

Cancer Sci· September 2024

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Exploratory Study Identifies Matrix Metalloproteinase-14 and -9 as Potential Biomarkers of Regorafenib Efficacy in Metastatic Colorectal Cancer.
Mitsukuni Suenaga, Tetsuo Mashima, Naomi Kawata, Shingo Dan, Hiroyuki Seimiya

Cancers (Basel)· August 2024

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Prediction of cell cycle distribution after drug exposure by high content imaging analysis using low-toxic DNA staining dye.
Kazuma Takeuchi, Yumiko Nishimura, Takayoshi Matsubara, Sho Isoyama, Asuka Suzuki, Shingo Dan

Pharmacol Res Perspect· June 2024

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A novel pan-PI3K inhibitor KTC1101 synergizes with anti-PD-1 therapy by targeting tumor suppression and immune activation.
Xin Peng, Xin Huang, Talal Ben Lulu, Wenqing Jia, Shaolu Zhang, Shingo Dan

Mol Cancer· March 2024

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Invivo anti-cancer activity of 10-methyl-aplog-1, a simplified analog of aplysiatoxin, and its possible signaling pathway associated with G1 arrest.
Yusuke Hanaki, Yuki Shikata, Masayuki Kikumori, Mutsumi Okamura, Shingo Dan

Biochem Biophys Res Commun· October 2023

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Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling.
Makoto Kawatani, Harumi Aono, Sayoko Hiranuma, Takeshi Shimizu, Makoto Muroi, Shingo Dan

Oncol Res· September 2023

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Discovery of novel DNA-damaging agents through phenotypic screening for DNA double-strand break.
Doudou Zhang, Takashi Shimokawa, Qianqian Guo, Shingo Dan, Yoshio Miki

Cancer Sci· March 2023

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Subtype-selective induction of apoptosis in translocation-related sarcoma cells induced by PUMA and BIM upon treatment with pan-PI3K inhibitors.
Sho Isoyama, Naomi Tamaki, Yutaka Noguchi, Mutsumi Okamura, Yuki Yoshimatsu, Shingo Dan

Cell Death Dis· February 2023

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Synthesis of Acetogenin Analogs Comprising Pyrimidine Moieties Linked by Amine Bonds and Their Inhibitory Activity against Human Cancer Cell Lines.
Hiroyuki Hosomi, Akinobu Akatsuka, Shingo Dan, Hiroki Iwasaki, Hisanori Nambu

Chem Pharm Bull (Tokyo)· November 2022

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Spautin-1 inhibits mitochondrial complex I and leads to suppression of the unfolded protein response and cell survival during glucose starvation.
Kazuhiro Kunimasa, Chika Ikeda-Ishikawa, Yuri Tani, Satomi Tsukahara, Junko Sakurai, Shingo Dan

Sci Rep· July 2022

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Structural Determination, Total Synthesis, and Biological Activity of Iezoside, a Highly Potent Ca-ATPase Inhibitor from the Marine Cyanobacterium .
Naoaki Kurisawa, Arihiro Iwasaki, Kazuya Teranuma, Shingo Dan, Chikashi Toyoshima

J Am Chem Soc· June 2022

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Gramicidin A accumulates in mitochondria, reduces ATP levels, induces mitophagy, and inhibits cancer cell growth.
Yun-Wei Xue, Hiroaki Itoh, Shingo Dan, Masayuki Inoue

Chem Sci· June 2022

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Structure-antitumor activity relationship of hybrid acetogenins focusing on connecting groups between heterocycles and the linker moiety.
Kaito Ohta, Tetsuya Fushimi, Mutsumi Okamura, Akinobu Akatsuka, Shingo Dan

RSC Adv· May 2022

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Development of Low-Molecular-Weight Compounds Targeting the Cancer-Associated KLF5 Transcription Factor.
Takeo Nakaya, Kenichi Aizawa, Yuki Taguchi, Kentaro Tsuji, Sachi Sekine, Shingo Dan

ACS Med Chem Lett· April 2022

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Isolation of new derivatives of the 20-membered macrodiolide bispolide from Kitasatospora sp. MG372-hF19.
Yasuko Kohda, Shuichi Sakamoto, Maya Umekita, Tomoyuki Kimura, Yumiko Kubota, Shingo Dan

J Antibiot (Tokyo)· February 2022

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Suppression of tumor metastasis by a RECK-activating small molecule.
Yoko Yoshida, Kanako Yuki, Shingo Dan, Kanami Yamazaki, Makoto Noda

Sci Rep· February 2022

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Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment.
Junjiro Yoshida, Tomokazu Ohishi, Hikaru Abe, Shun-Ichi Ohba, Hiroyuki Inoue, Shingo Dan

iScience· December 2021

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Structure-Activity Relationships of Thiophene Carboxamide Annonaceous Acetogenin Analogs: Shortening the Alkyl Chain in the Tail Part Significantly Affects Their Growth Inhibitory Activity against Human Cancer Cell Lines.
Kaito Ohta, Akinobu Akatsuka, Shingo Dan, Hiroki Iwasaki, Masayuki Yamashita

Chem Pharm Bull (Tokyo)· November 2021

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Identification of Dihydroorotate Dehydrogenase Inhibitors─Indoluidins─That Inhibit Cancer Cell Growth.
Makoto Kawatani, Harumi Aono, Takeshi Shimizu, Shouta Ohkura, Sayoko Hiranuma, Shingo Dan

ACS Chem Biol· November 2021

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Cancer immunotherapy with PI3K and PD-1 dual-blockade via optimal modulation of T cell activation signal.
Sho Isoyama, Shigeyuki Mori, Daisuke Sugiyama, Yasuhiro Kojima, Yasuko Tada, Shingo Dan

J Immunother Cancer· August 2021

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Effects of side chain length of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, on PKC binding, anti-proliferative, and pro-inflammatory activities.
Atsuko Gonda, Koji Takada, Ryo C Yanagita, Shingo Dan, Kazuhiro Irie

Biosci Biotechnol Biochem· January 2021

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