Publications by authors named "Shingo Obika"

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Discovery and SAR of JTE-151: A Novel RORγ Inhibitor for Clinical Development.
Takaki Maeba, Kazuyuki Hirata, Masayuki Kotoku, Noriyoshi Seki, Katsuya Maeda, Shingo Obika

J Med Chem· January 2024

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Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors.
Yuki Bessho, Tatsuo Akaki, Yoshinori Hara, Maki Yamakawa, Shingo Obika

Bioorg Med Chem· December 2021

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Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders.
Satoru Noji, Yoshinori Hara, Tomoya Miura, Hiroshi Yamanaka, Katsuya Maeda, Shingo Obika

J Med Chem· July 2020

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Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.
Daisuke Oikawa, Yusuke Sato, Fumiaki Ohtake, Keidai Komakura, Kazuki Hanada, Shingo Obika

Commun Biol· April 2020

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Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling.
Ken Katsuya, Daisuke Oikawa, Kiyosei Iio, Shingo Obika, Yuji Hori

Biochem Biophys Res Commun· February 2019

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SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious RORγ Inhibitor.
Kazuyuki Hirata, Masayuki Kotoku, Noriyoshi Seki, Takaki Maeba, Katsuya Maeda, Shingo Obika

ACS Med Chem Lett· January 2016

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Concise synthesis of the CDE ring system of tetrahydroisoquinoline alkaloids using carbophilic Lewis acid-catalyzed hydroamidation and oxidative Friedel-Crafts cyclization.
Shingo Obika, Yoshizumi Yasui, Reiko Yanada, Yoshiji Takemoto

J Org Chem· July 2008

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Concise synthesis of 1,2-dihydroisoquinolines and 1H-isochromenes by carbophilic lewis acid-catalyzed tandem nucleophilic addition and cyclization of 2-(1-alkynyl)arylaldimines and 2-(1-alkynyl)arylaldehydes.
Shingo Obika, Hideki Kono, Yoshizumi Yasui, Reiko Yanada, Yoshiji Takemoto

J Org Chem· June 2007

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In(OTf)3-catalyzed tandem nucleophilic addition and cyclization of ortho-alkynylarylaldimines to 1,2-dihydroisoquinolines.
Reiko Yanada, Shingo Obika, Hideki Kono, Yoshiji Takemoto

Angew Chem Int Ed Engl· June 2006

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Stereoselective synthesis of 3-alkylideneoxindoles via palladium-catalyzed domino reactions.
Reiko Yanada, Shingo Obika, Tsubasa Inokuma, Kazuo Yanada, Masayuki Yamashita

J Org Chem· August 2005

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Stereoselective synthesis of 3-alkylideneoxindoles using tandem In-mediated carbometalation and Pd-catalyzed cross-coupling reaction.
Reiko Yanada, Shingo Obika, Munetaka Oyama, Yoshiji Takemoto

Org Lett· August 2004

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Indium-mediated atom-transfer and reductive radical cyclizations of iodoalkynes: synthesis and biological evaluation of HIV-protease inhibitors.
Reiko Yanada, Yasuhiro Koh, Nobuaki Nishimori, Akira Matsumura, Shingo Obika

J Org Chem· April 2004

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