Publications by authors named "Shinichi Uesato"

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Discovery of novel disulfide-containing PD-1/PD-L1 inhibitor with in vivo influenza therapeutic efficacy.
Yoshiyuki Hirata, Kyoko Hayashi, Takuma Kato, Yasuo Nagaoka, Mitsunobu Doi, Shinichi Uesato

Sci Rep· September 2025

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Experimental and DFT Studies of Intermolecular Interaction-Assisted Oxindole Cyclization Reaction of Di-t-butyl 2-Aminophenyl-2-methyl Malonate.
Ryo Kakehi, Yu-Suke Yamai, Akio Tanaka, Kyoji Ishida, Shinichi Uesato

Chem Pharm Bull (Tokyo)· January 2025

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Isozyme-specific histone deacetylase 1/2 inhibitor K560 attenuates oxidative stress-induced retinal cell death.
Hiroshi Tawarayama, Yoshiyuki Hirata, Keiko Uchida, Noriko Himori, Shinichi Uesato

Neurosci Lett· January 2023

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MDMX elevation by a novel Mdmx-p53 interaction inhibitor mitigates neuronal damage after ischemic stroke.
Haomin Yan, Tsutomu Sasaki, Hideaki Kanki, Yoshiyuki Hirata, Kumiko Nishiyama, Shinichi Uesato

Sci Rep· December 2022

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[Isoform Selectivity of HDAC Inhibitors Has a Significant Effect on PD-L1 Expression in the Triple-negative Cancer Cell Line MDA-MB-231].
Hinata Nishino, Yoshiyuki Hirata, Yasuo Nagaoka, Shinichi Uesato

Yakugaku Zasshi· April 2022

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Potential Application of 5-Aryl-Substituted 2-Aminobenzamide Type of HDAC1/2- Selective Inhibitors to Pharmaceuticals.
Shinichi Uesato, Yoshiyuki Hirata, Tsutomu Sasaki

Curr Pharm Des· July 2019

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New 5-Aryl-Substituted 2-Aminobenzamide-Type HDAC Inhibitors with a Diketopiperazine Group and Their Ameliorating Effects on Ischemia-Induced Neuronal Cell Death.
Yoshiyuki Hirata, Tsutomu Sasaki, Hideaki Kanki, Chi-Jing Choong, Kumiko Nishiyama, Shinichi Uesato

Sci Rep· January 2018

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Discovery of new low-molecular-weight p53-Mdmx disruptors and their anti-cancer activities.
Shinichi Uesato, Yoshihiro Matsuura, Saki Matsue, Takaaki Sumiyoshi, Yoshiyuki Hirata

Bioorg Med Chem· April 2016

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A novel histone deacetylase 1 and 2 isoform-specific inhibitor alleviates experimental Parkinson's disease.
Chi-Jing Choong, Tsutomu Sasaki, Hideki Hayakawa, Toru Yasuda, Kousuke Baba, Shinichi Uesato

Neurobiol Aging· January 2016

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Influence of the carbamate fungicide benomyl on the gene expression and activity of aromatase in the human breast carcinoma cell line MCF-7.
Yasuyuki Kawaratani, Takeshi Matsuoka, Yoshiyuki Hirata, Naofumi Fukata, Yasuo Nagaoka, Shinichi Uesato

Environ Toxicol Pharmacol· January 2015

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Synergistic antitumor effect of a combination of paclitaxel and carboplatin with nobiletin from Citrus depressa on non-small-cell lung cancer cell lines.
Shinichi Uesato, Hirofumi Yamashita, Ryu Maeda, Yoshiyuki Hirata, Maho Yamamoto

Planta Med· April 2014

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Induction of melanogenesis by 4'-O-methylated flavonoids in B16F10 melanoma cells.
Ippei Horibe, Yudai Satoh, Yuki Shiota, Ayako Kumagai, Nanao Horike, Shinichi Uesato

J Nat Med· October 2013

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Blockade of the ERK pathway enhances the therapeutic efficacy of the histone deacetylase inhibitor MS-275 in human tumor xenograft models.
Toshiaki Sakamoto, Kei-ichi Ozaki, Kohsuke Fujio, Shu-hei Kajikawa, Shin-ichi Uesato

Biochem Biophys Res Commun· April 2013

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Antitumor effect of liposomal histone deacetylase inhibitor-lipid conjugates in vitro.
Yoshiyuki Hattori, Yasuo Nagaoka, Manami Kubo, Haruka Yamasaku, Yuta Ishii, Shinichi Uesato

Chem Pharm Bull (Tokyo)· March 2012

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Anti-tumor activity of new orally bioavailable 2-amino-5-(thiophen-2-yl)benzamide-series histone deacetylase inhibitors, possessing an aqueous soluble functional group as a surface recognition domain.
Yoshiyuki Hirata, Masahiko Hirata, Yasuyuki Kawaratani, Makio Shibano, Masahiko Taniguchi, Shinichi Uesato

Bioorg Med Chem Lett· March 2012

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A potent inhibitor of SIK2, 3, 3', 7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells.
Ayako Kumagai, Nanao Horike, Yudai Satoh, Tatsuya Uebi, Tsutomu Sasaki, Shinichi Uesato

PLoS One· February 2012

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New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group.
Yasuyuki Kawaratani, Tomohiko Harada, Yoshiyuki Hirata, Yasuo Nagaoka, Susumu Tanimura, Shinichi Uesato

Bioorg Med Chem· July 2011

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Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus.
Kyoko Hayashi, Kazuto Narutaki, Yasuo Nagaoka, Toshimitsu Hayashi, Shinichi Uesato

Biol Pharm Bull· November 2010

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New orally bioavailable 2-aminobenzamide-type histone deacetylase inhibitor possessing a (2-hydroxyethyl)(4-(thiophen-2-yl)benzyl)amino group.
Shingo Kiyokawa, Yoshiyuki Hirata, Yasuo Nagaoka, Makio Shibano, Masahiko Taniguchi, Shinichi Uesato

Bioorg Med Chem· June 2010

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Histone deacetylase inhibitor prodrugs in nanoparticle vector enhanced gene expression in human cancer cells.
Yuta Ishii, Yoshiyuki Hattori, Toshiharu Yamada, Shinichi Uesato, Yoshie Maitani

Eur J Med Chem· November 2009

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Inhibitory effect of (-)-epigallocatechin and (-)-epigallocatechin gallate against heregulin beta1-induced migration/invasion of the MCF-7 breast carcinoma cell line.
Yukihiro Kushima, Kazuki Iida, Yasuo Nagaoka, Yasuyuki Kawaratani, Tatsuya Shirahama, Shinichi Uesato

Biol Pharm Bull· May 2009

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Attempt to detect natural anticancer compounds--protein binding through precursor ion scan and MS/MS measurements.
Jun Negishi, Tatsuya Shirahama, Yasuo Nagaoka, Yoshiki Takemoto, Shinichi Uesato

Yakugaku Zasshi· September 2008

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Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells.
Yasuo Nagaoka, Kota Otsuki, Tetsuro Fujita, Shinichi Uesato

Biol Pharm Bull· June 2008

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Growth inhibition of human colon cancer cell line HCT116 by bis[2-(acylamino)phenyl] disulfide and its action mechanism.
Satoshi Yamakawa, Aya Demizu, Yasuyuki Kawaratani, Yasuo Nagaoka, Yuji Terada, Shinichi Uesato

Biol Pharm Bull· May 2008

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Comparative examination of anti-proliferative activities of (-)-epigallocatechin gallate and (--)-epigallocatechin against HCT116 colorectal carcinoma cells.
Hiroyuki Inaba, Yasuo Nagaoka, Yukihiro Kushima, Ayako Kumagai, Yoshinori Matsumoto, Shinichi Uesato

Biol Pharm Bull· January 2008

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