Publications by authors named "Shinji Hadano"

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Investigation of early axonal phenotypes in an iPSC-derived ALS cellular model using a microfluidic device.
Asako Otomo, Keiko Nishijima, Yuta Murakami, Mitsuru Ishikawa, Haruka Yudahira, Shinji Hadano

Front Cell Neurosci· July 2025

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Soymilk yogurt prepared using TOKAI 759m ameliorates cognitive function through gut microbiota modulation in high-fat diet mice.
Yuki Nakashima, Tomoyuki Hibi, Masafumi Urakami, Maki Hoshino, Taiki Morii, Shinji Hadano

Curr Res Food Sci· February 2025

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Preclinical alternative drug discovery programs for monogenic rare diseases. Should small molecules or gene therapy be used? The case of hereditary spastic paraplegias.
Matteo Rossi Sebastiano, Shinji Hadano, Fabrizia Cesca, , Giuseppe Ermondi

Drug Discov Today· October 2024

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Rare and variants identified as candidate factors associated with eating disorders in Japanese patients by whole exome sequencing.
Akira Oka, Shinji Hadano, Mahoko Takahashi Ueda, So Nakagawa, Gen Komaki

Heliyon· April 2024

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Effect of PCDH19 missense mutations on cell-to-cell proximity and neuronal development under heterotypic conditions.
Nami Motosugi, Akiko Sugiyama, Asako Otomo, Yuka Sakata, Takuma Araki, Shinji Hadano

PNAS Nexus· March 2024

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Genetic and clinical characteristics of ALS patients with NEK1 gene variants.
Qirui Jiang, Junyu Lin, Qianqian Wei, Chunyu Li, Yanbing Hou, Shinji Hadano

Neurobiol Aging· March 2023

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Central nervous system specific high molecular weight ALS2/alsin homophilic complex is enriched in mouse brain synaptosomes.
Kai Sato, Kyoko Suzuki-Utsunomiya, Shun Mitsui, Suzuka Ono, Kento Shimakura, Shinji Hadano

Biochem Biophys Res Commun· January 2023

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De-erosion of X chromosome dosage compensation by the editing of regulatory regions restores the differentiation potential in hPSCs.
Nami Motosugi, Akiko Sugiyama, Chisa Okada, Asako Otomo, Akihiro Umezawa, Shinji Hadano

Cell Rep Methods· December 2022

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Personalized Treatment for Infantile Ascending Hereditary Spastic Paralysis Based on In Silico Strategies.
Matteo Rossi Sebastiano, Giuseppe Ermondi, Kai Sato, Asako Otomo, Shinji Hadano

Molecules· October 2022

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SQSTM1, a protective factor of SOD1-linked motor neuron disease, regulates the accumulation and distribution of ubiquitinated protein aggregates in neuron.
Shun Mitsui, Asako Otomo, Kai Sato, Masahito Ishiyama, Kento Shimakura, Shinji Hadano

Neurochem Int· September 2022

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AI-based protein structure databases have the potential to accelerate rare diseases research: AlphaFoldDB and the case of IAHSP/Alsin.
Matteo Rossi Sebastiano, Giuseppe Ermondi, Shinji Hadano, Giulia Caron

Drug Discov Today· June 2022

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High-throughput quantitative analysis of axonal transport in cultured neurons from SOD1 ALS mice by using a microfluidic device.
Asako Otomo, Suzuka Ono, Kai Sato, Shun Mitsui, Kento Shimakura, Shinji Hadano

Neurosci Res· January 2022

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The N-terminal intrinsically disordered region mediates intracellular localization and self-oligomerization of ALS2.
Kento Shimakura, Kai Sato, Shun Mitsui, Suzuka Ono, Asako Otomo, Shinji Hadano

Biochem Biophys Res Commun· September 2021

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SQSTM1 variant that is linked to sporadic ALS exhibits impaired association with MAP1LC3 in cultured cells.
Masahisa Nozaki, Asako Otomo, Shun Mitsui, Suzuka Ono, Ryohei Shirakawa, Shinji Hadano

eNeurologicalSci· March 2021

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Daniel J Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Shinji Hadano

Autophagy· January 2021

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Monitoring the autophagy-endolysosomal system using monomeric Keima-fused MAP1LC3B.
Hideki Hayashi, Ting Wang, Masayuki Tanaka, Sanae Ogiwara, Chisa Okada, Shinji Hadano

PLoS One· August 2020

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Alopecia areata susceptibility variant in MHC region impacts expressions of genes contributing to hair keratinization and is involved in hair loss.
Akira Oka, Atsushi Takagi, Etsuko Komiyama, Nagisa Yoshihara, Shuhei Mano, Shinji Hadano

EBioMedicine· July 2020

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Efficient differentiation and polarization of primary cultured neurons on poly(lactic acid) scaffolds with microgrooved structures.
Asako Otomo, Mahoko Takahashi Ueda, Toshinori Fujie, Arihiro Hasebe, Yoshitaka Suematsu, Shinji Hadano

Sci Rep· April 2020

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ALS2, the small GTPase Rab17-interacting protein, regulates maturation and sorting of Rab17-associated endosomes.
Suzuka Ono, Asako Otomo, Shuji Murakoshi, Shun Mitsui, Kai Sato, Shinji Hadano

Biochem Biophys Res Commun· March 2020

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Rostrocaudal Areal Patterning of Human PSC-Derived Cortical Neurons by FGF8 Signaling.
Kent Imaizumi, Koki Fujimori, Seiji Ishii, Asako Otomo, Yasushi Hosoi, Shinji Hadano

eNeuro· January 2019

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Altered oligomeric states in pathogenic ALS2 variants associated with juvenile motor neuron diseases cause loss of ALS2-mediated endosomal function.
Kai Sato, Asako Otomo, Mahoko Takahashi Ueda, Yui Hiratsuka, Kyoko Suzuki-Utsunomiya, Shinji Hadano

J Biol Chem· November 2018

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Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent.
Koki Fujimori, Mitsuru Ishikawa, Asako Otomo, Naoki Atsuta, Ryoichi Nakamura, Shinji Hadano

Nat Med· October 2018

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Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1-expressing ALS mouse model.
Shun Mitsui, Asako Otomo, Masahisa Nozaki, Suzuka Ono, Kai Sato, Shinji Hadano

Mol Brain· May 2018

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A novel function of N-linked glycoproteins, alpha-2-HS-glycoprotein and hemopexin: Implications for small molecule compound-mediated neuroprotection.
Takuya Kanno, Kaori Yasutake, Kazunori Tanaka, Shinji Hadano, Joh-E Ikeda

PLoS One· October 2017

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Inositol Hexakisphosphate Kinase 2 is a Presymptomatic Biomarker for Amyotrophic Lateral Sclerosis.
Yusuke Moriya, Eiichiro Nagata, Natsuko Fujii, Tadayuki Satoh, Haruko Ogawa, Shinji Hadano

Tokai J Exp Clin Med· April 2017

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