Publications by authors named "Shinji Takasu"

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Evaluation of 2-isopropyl-N-2,3-trimethylbutyramide by a comprehensive toxicity study using gpt delta rats.
Tatsuya Mitsumoto, Yuji Ishii, Norifumi Takimoto, Shinji Takasu, Moeka Namiki

Toxicol Appl Pharmacol· December 2025

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Developing a novel in vitro toxicity assay for predicting inhalation toxicity in rats.
Arpamas Vachiraarunwong, Masaki Fujioka, David B Alexander, Shugo Suzuki, Runjie Guo, Shinji Takasu

Toxicol Lett· December 2025

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A 28-day subacute toxicity study of puberulic acid in Crl:CD(SD) rats.
Kohei Matsushita, Genichiro Tsuji, Hirotoshi Akane, Yuji Ishii, Shinji Takasu

J Toxicol Pathol· October 2025

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Involvement of nuclear atrophy of binucleated hepatocytes in the large micronucleus formation induced by rat hepatocarcinogen acetamide.
Norifumi Takimoto, Yuji Ishii, Tatsuya Mitsumoto, Shinji Takasu, Moeka Namiki

Toxicol Appl Pharmacol· March 2025

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Appearance of sex-determining region Y-box 9 (SOX9)- and glutathione S-transferase placental form (GST-P)-positive hepatocytes as possible carcinogenic events in the early stage of furan-induced hepatocarcinogenesis.
Daisuke Hibi, Meili Soma, Yuta Suzuki, Shinji Takasu, Yuji Ishii

J Appl Toxicol· December 2024

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Chromosome aberrations cause tumorigenesis through chromosomal rearrangements in a hepatocarcinogenesis rat model.
Kenji Nakamura, Yuji Ishii, Shinji Takasu, Moeka Namiki, Meili Soma

Cancer Sci· November 2024

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Possible contribution of 8-hydroxydeoxyguanosine to gene mutations in the kidney DNA of gpt delta rats following potassium bromate treatment.
Ken Kuroda, Yuji Ishii, Shinji Takasu, Aki Kijima, Kohei Matsushita

Mutat Res Genet Toxicol Environ Mutagen· March 2024

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Formation of hepatocyte cytoplasmic inclusions and their contribution to methylcarbamate-induced hepatocarcinogenesis in F344 rats.
Norifumi Takimoto, Yuji Ishii, Tatsuya Mitsumoto, Shinji Takasu, Moeka Namiki

Toxicol Sci· February 2024

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Site-specific genotoxicity of rubiadin: localization and histopathological changes in the kidneys of rats.
Tatsuya Mitsumoto, Yuji Ishii, Norifumi Takimoto, Shinji Takasu, Moeka Namiki

Arch Toxicol· December 2023

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A 13-week comprehensive toxicity study with adductome analysis demonstrates the toxicity, genotoxicity, and carcinogenicity of the natural flavoring agent elemicin.
Yuji Ishii, Liang Shi, Shinji Takasu, Kumiko Ogawa, Takashi Umemura

Food Chem Toxicol· September 2023

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Comprehensive analysis of the general toxicity, genotoxicity, and carcinogenicity of 3-acetyl-2,5-dimethylfuran in male gpt delta rats.
Shinji Takasu, Yuji Ishii, Moeka Namiki, Kenji Nakamura, Tatsuya Mitsumoto

Food Chem Toxicol· February 2023

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Toxicity, genotoxicity, and carcinogenicity of 2-methylfuran in a 90-day comprehensive toxicity study in gpt delta rats.
Ken Kuroda, Yuji Ishii, Shinji Takasu, Kohei Matsushita, Aki Kijima

Food Chem Toxicol· October 2022

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Visualization of the distribution of anthraquinone components from madder roots in rat kidneys by desorption electrospray ionization-time-of-flight mass spectrometry imaging.
Yuji Ishii, Kenji Nakamura, Tatsuya Mitsumoto, Norifumi Takimoto, Moeka Namiki, Shinji Takasu

Food Chem Toxicol· March 2022

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A 90-day subchronic toxicity study of Myrrh in F344 rats.
Tatsuya Mitsumoto, Yuji Ishii, Moeka Namiki, Kenji Nakamura, Shinji Takasu

Regul Toxicol Pharmacol· December 2021

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In vivo mutagenicity and tumor-promoting activity of 1,3-dichloro-2-propanol in the liver and kidneys of gpt delta rats.
Kohei Matsushita, Shinji Takasu, Yuji Ishii, Takeshi Toyoda, Takanori Yamada

Arch Toxicol· September 2021

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Chromosome aberrations induced by the non-mutagenic carcinogen acetamide involve in rat hepatocarcinogenesis through micronucleus formation in hepatocytes.
Kenji Nakamura, Yuji Ishii, Shinji Takasu, Takehiko Nohmi, Makoto Shibutani

Arch Toxicol· August 2021

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The role of DNA polymerase ζ in benzo[a]pyrene-induced mutagenesis in the mouse lung.
Yuji Ishii, Shinji Takasu, Petr Grúz, Kenichi Masumura, Kumiko Ogawa

Mutagenesis· May 2021

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A 90-day subchronic toxicity study of 5-methyl-2-phenyl-2-hexenal in F344 rats.
Kenji Nakamura, Yuji Ishii, Shinji Takasu, Kumiko Ogawa

Food Chem Toxicol· April 2021

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Background data of 2-year-old male and female F344 delta rats.
Kohei Matsushita, Yuji Ishii, Aki Kijima, Shinji Takasu, Ken Kuroda

J Toxicol Pathol· January 2021

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Lack of In Vivo Mutagenicity of Acetamide in a 13-Week Comprehensive Toxicity Study Using F344 gpt Delta Rats.
Kenji Nakamura, Yuji Ishii, Shinji Takasu, Takehiko Nohmi, Makoto Shibutani

Toxicol Sci· October 2020

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Furan Induced Characteristic Glutathione -Transferase Placental Form-Positive Foci in Terms of Cell Kinetics and Gene Expression.
Shinji Takasu, Yuji Ishii, Aki Kijima, Kumiko Ogawa, Sae Nakane

Toxicol Pathol· August 2020

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DNA modifications that do not cause gene mutations confer the potential for mutagenicity by combined treatment with food chemicals.
Yuji Ishii, Yuh Yokoo, Aki Kijima, Shinji Takasu, Kumiko Ogawa

Food Chem Toxicol· July 2019

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Effects of inhibition of hepatic sulfotransferase activity on renal genotoxicity induced by lucidin-3-O-primeveroside.
Yuji Ishii, Aki Kijima, Shinji Takasu, Kumiko Ogawa, Takashi Umemura

J Appl Toxicol· April 2019

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Molecular Pathological Differences in Global Gene Expression between Two Sustained Proliferative Lesions, Nodular Regenerative Hepatocellular Hyperplasia and Hepatocellular Adenoma, in Mice.
Shinji Takasu, Yuh Yokoo, Yuji Ishii, Aki Kijima, Kumiko Ogawa

Toxicol Pathol· January 2019

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Mechanisms of oxidative stress-induced mutagenicity by potassium bromate and nitrofurantoin.
Takuma Tsuchiya, Aki Kijima, Yuji Ishii, Shinji Takasu, Yuh Yokoo

J Toxicol Pathol· July 2018

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