Publications by authors named "Shinji Takechi"

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UDP-glucuronosyltransferase 1A9 function is mediated by the two C-terminal lysine residues and proper mobility/flexibility of the cytoplasmic tail.
Yuu Miyauchi, Yume Sadato, Madoka Sawai, Shinji Takechi, Masahiro Hiratsuka

Biochem Biophys Res Commun· January 2026

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Dihydropyrazine activates the CAMKK2-AMPK-ULK1 signaling pathway in human hepatoma HepG2 cells.
Madoka Sawai, Yuu Miyauchi, Hisao Kansui, Shinji Takechi

J Toxicol Sci· October 2025

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Disulfide bond-mediated stabilization of the oligomers of UDP-glucuronosyltransferase 2B7.
Yuu Miyauchi, Haruna Koba, Madoka Sawai, Hisao Kansui, Shinji Takechi

J Biol Chem· September 2025

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Dihydropyrazine induces endoplasmic reticulum stress and inhibits autophagy in HepG2 human hepatoma cells.
Shinji Takechi, Madoka Sawai, Yuu Miyauchi

J Toxicol Sci· June 2024

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Saponin Esculeoside A and Aglycon Esculeogenin A from Ripe Tomatoes Inhibit Dendritic Cell Function by Attenuation of Toll-like Receptor 4 Signaling.
Jian-Rong Zhou, Shigenori Kinno, Kenta Kaihara, Madoka Sawai, Takumi Ishida, Shinji Takechi

Nutrients· May 2024

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Oxidative stress and cellular toxicity induced by dihydropyrazine: a comparative study with other Maillard reaction products.
Yuu Miyauchi, Haruna Koba, Madoka Sawai, Hisao Kansui, Shinji Takechi

J Toxicol Sci· May 2023

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Dihydropyrazine suppresses TLR4-dependent inflammatory responses by blocking MAPK signaling in human hepatoma HepG2 cells.
Madoka Sawai, Yuu Miyauchi, Takumi Ishida, Shinji Takechi

J Toxicol Sci· September 2022

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Functional Interaction between Cytochrome P450 and UDP-Glucuronosyltransferase on the Endoplasmic Reticulum Membrane: One of Post-translational Factors Which Possibly Contributes to Their Inter-Individual Differences.
Yuu Miyauchi, Shinji Takechi, Yuji Ishii

Biol Pharm Bull· February 2022

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Use of a Baculovirus-Mammalian Cell Expression-System for Expression of Drug-Metabolizing Enzymes: Optimization of Infection With a Focus on Cytochrome P450 3A4.
Yuu Miyauchi, Akane Kimura, Madoka Sawai, Keiko Fujimoto, Yuko Hirota, Shinji Takechi

Front Pharmacol· February 2022

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Molecular mechanism of dihydropyrazine-induced cytotoxicity: the possibility of an independent pathway from the receptor for advanced glycation end products.
Yuu Miyauchi, Madoka Sawai, Takumi Ishida, Hisao Kansui, Shinji Takechi

J Toxicol Sci· January 2022

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The carboxyl-terminal di-lysine motif is essential for catalytic activity of UDP-glucuronosyltransferase 1A9.
Yuu Miyauchi, Ken Kurohara, Akane Kimura, Madoka Esaki, Keiko Fujimoto, Shinji Takechi

Drug Metab Pharmacokinet· October 2020

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The effect of dihydropyrazines on lipopolysaccharide-stimulated human hepatoma HepG2 cells via regulating the TLR4-MyD88-mediated NF-κB signaling pathway.
Madoka Esaki, Takumi Ishida, Yuu Miyauchi, Shinji Takechi

J Toxicol Sci· September 2020

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β-Naphthoflavone, an exogenous ligand of aryl hydrocarbon receptor, disrupts zinc homeostasis in human hepatoma HepG2 cells.
Takumi Ishida, Shinji Takechi

J Toxicol Sci· February 2020

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Atypical Familial Amyotrophic Lateral Sclerosis with Slowly Progressing Lower Extremities-predominant Late-onset Muscular Weakness and Atrophy.
Jumpei Togawa, Takekazu Ohi, Jun-Hui Yuan, Hiroshi Takashima, Hirokazu Furuya, Shinji Takechi

Intern Med· October 2019

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Nrf2-ARE-Dependent Alterations in Zinc Transporter mRNA Expression in HepG2 Cells.
Takumi Ishida, Shinji Takechi

PLoS One· June 2017

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3-Hydro-2,2,5,6-tetramethylpyrazine: A novel inducer of zinc transporter-1 in HepG2 human hepatocellular carcinoma cells.
Takumi Ishida, Tadatoshi Yamaguchi, Shinji Takechi

Arch Biochem Biophys· August 2015

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Identification of dihydropyrazine-glutathione adducts.
Shinji Takechi, Shigeru Ito, Nobuhiro Kashige, Takumi Ishida, Tadatoshi Yamaguchi

J Toxicol Sci· August 2015

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Effect of dihydropyrazines on human hepatoma HepG2 cells: a comparative study using 2,3-dihydro-5,6-dimethylpyrazine and 3-hydro-2,2,5,6-tetramethylpyrazine.
Takumi Ishida, Tadatoshi Yamaguchi, Shinji Takechi

J Toxicol Sci· August 2014

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Selenium-binding protein 1: its physiological function, dependence on aryl hydrocarbon receptors, and role in wasting syndrome by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Sayuri Tsujimoto, Takumi Ishida, Tomoki Takeda, Yuji Ishii, Yuko Onomura, Shinji Takechi

Biochim Biophys Acta· June 2013

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Possible involvement of glutathione balance disruption in dihydropyrazine-induced cytotoxicity on human hepatoma HepG2 cells.
Takumi Ishida, Shinji Takechi, Tadatoshi Yamaguchi

J Toxicol Sci· March 2013

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Generation of radical species from dihydropyrazines having DNA strand-breakage activity and other characteristics.
Tadatoshi Yamaguchi, Shigenobu Matsumoto, Toshiki Masumizu, Shinji Takechi, Takumi Ishida

Chem Pharm Bull (Tokyo)· October 2012

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2,3,7,8-tetrachlorodibenzo-p-dioxin potentially attenuates the gene expression of pituitary gonadotropin β-subunits in a fetal age-specific fashion: a comparative study using cultured pituitaries.
Tomoki Takeda, Midori Yamamoto, Masaru Himeno, Shinji Takechi, Tadatoshi Yamaguchi

J Toxicol Sci· April 2011

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Glutathione depression by dihydropyrazine derivative.
Shinji Takechi, Shigeru Ito, Nobuhiro Kashige, Takumi Ishida, Tadatoshi Yamaguchi

J Toxicol Sci· April 2011

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Latent enamine functionality of 5-methyl-2,3-dihydropyrazines.
Shigeru Ito, Tomoya Hirano, Akiko Sugimoto, Hiroyuki Kagechika, Shinji Takechi

Chem Pharm Bull (Tokyo)· July 2010

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Phenyl-substituted dihydropyrazines with DNA strand-breakage activity.
Shigeru Ito, Shinji Takechi, Kazuhide Nakahara, Nobuhiro Kashige, Tadatoshi Yamaguchi

Chem Pharm Bull (Tokyo)· June 2010

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