Publications by authors named "Shira Perl"

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Efficacy and Safety of Baxdrostat in Uncontrolled and Resistant Hypertension.
John M Flack, Michel Azizi, Jenifer M Brown, Jamie P Dwyer, Jakub Fronczek, Erika S W Jones, Daniel S Olsson, Shira Perl, Hirotaka Shibata, Ji-Guang Wang

October 2025

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Baxdrostat for uncontrolled and resistant hypertension: rationale and design of the Phase 3 clinical trials BaxHTN, BaxAsia, and Bax24.
John M Flack, Michel Azizi, Jenifer M Brown, Jamie P Dwyer, Erika S W Jones, Shira Perl

Hypertens Res· November 2025

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Phase 2a Study of Baxdrostat in Primary Aldosteronism.
Adina F Turcu, Mason W Freeman, Irina Bancos, Anat Ben-Shlomo, Oksana Hamidi, Shira Perl

N Engl J Med· July 2025

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Verinurad Plus Allopurinol for Heart Failure With Preserved Ejection Fraction: The AMETHYST Randomized Clinical Trial.
Dalane W Kitzman, Adriaan A Voors, Robert J Mentz, Gregory D Lewis, Shira Perl

JAMA Cardiol· October 2024

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Acute and persistent responses after H5N1 vaccination in humans.
Richard Apps, Angélique Biancotto, Julián Candia, Yuri Kotliarov, Shira Perl

Cell Rep· September 2024

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Urate-lowering therapy in patients with hyperuricemia and heart failure: A retrospective cohort study using the UK Clinical Practice Research Datalink.
Steven J Kiddle, Karolina Andersson Sundell, Shira Perl, Stephen Nolan, Magnus Bjursell

Clin Cardiol· June 2024

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Combination Treatment with Verinurad and Allopurinol in CKD: A Randomized Placebo and Active Controlled Trial.
Hiddo J L Heerspink, Austin G Stack, Robert Terkeltaub, Niels Jongs, Lesley A Inker, Shira Perl

J Am Soc Nephrol· May 2024

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Verinurad does not prolong QTc interval: a thorough QT study using concentration-QTc modelling.
Joanna Parkinson, Corina Dota, Christian Källgren, Christer Gottfridsson, Magnus Bjursell, Shira Perl

Br J Clin Pharmacol· June 2023

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Rationale, design, demographics and baseline characteristics of the randomized, controlled, Phase 2b SAPPHIRE study of verinurad plus allopurinol in patients with chronic kidney disease and hyperuricaemia.
Hiddo J L Heerspink, Austin G Stack, Robert Terkeltaub, Tom A Greene, Lesley A Inker, Shira Perl

Nephrol Dial Transplant· July 2022

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Elevated Uric Acid Prevalence and Clinical Outcomes in Patients with Heart Failure with Preserved Ejection Fraction: Insights from RELAX.
Anthony P Carnicelli, Jie-Lena Sun, Brooke Alhanti, Magnus Bjursell, Shira Perl

Am J Med· December 2020

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Comparison of Characteristics and Outcomes of Patients With Heart Failure With Preserved Ejection Fraction With Versus Without Hyperuricemia or Gout.
Anthony P Carnicelli, Robert Clare, Karen Chiswell, Barbara Lytle, Magnus Bjursell, Shira Perl

Am J Cardiol· July 2020

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Effects of rosuvastatin on the immune system in healthy volunteers with normal serum cholesterol.
Peer Wf Karmaus, Min Shi, Shira Perl, Angélique Biancotto, Julián Candia

JCI Insight· November 2019

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Triple therapy with low-dose dapagliflozin plus saxagliptin versus dual therapy with each monocomponent, all added to metformin, in uncontrolled type 2 diabetes.
Julio Rosenstock, Shira Perl, Eva Johnsson, Ricardo García-Sánchez, Stephan Jacob

Diabetes Obes Metab· September 2019

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The Immunome in Two Inherited Forms of Pulmonary Fibrosis.
Souheil El-Chemaly, Foo Cheung, Yuri Kotliarov, Kevin J O'Brien, William A Gahl, Shira Y Perl

Front Immunol· February 2019

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The Lifespan and Turnover of Microglia in the Human Brain.
Pedro Réu, Azadeh Khosravi, Samuel Bernard, Jeff E Mold, Mehran Salehpour, Shira Perl

Cell Rep· July 2017

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Effects of Glimepiride versus Saxagliptin on β-Cell Function and Hypoglycemia: A Post Hoc Analysis in Older Patients with Type 2 Diabetes Inadequately Controlled with Metformin.
Shira Perl, William Cook, Cheryl Wei, Peter Ohman, Boaz Hirshberg

Clin Ther· December 2016

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Saxagliptin Efficacy and Safety in Patients With Type 2 Diabetes and Moderate Renal Impairment.
Shira Perl, William Cook, Cheryl Wei, Nayyar Iqbal, Boaz Hirshberg

Diabetes Ther· September 2016

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Rosuvastatin Alters the Proteome of High Density Lipoproteins: Generation of alpha-1-antitrypsin Enriched Particles with Anti-inflammatory Properties.
Scott M Gordon, Benjamin McKenzie, Georgina Kemeh, Maureen Sampson, Shira Perl

Mol Cell Proteomics· December 2015

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Correction: Baseline Levels and Temporal Stability of 27 Multiplexed Serum Cytokine Concentrations in Healthy Subjects.
Angelique Biancotto, Abigail Wank, Shira Perl, Wendell Cook, Matthew J Olnes

PLoS One· September 2015

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Dynamics of oligodendrocyte generation and myelination in the human brain.
Maggie S Y Yeung, Sofia Zdunek, Olaf Bergmann, Samuel Bernard, Mehran Salehpour, Shira Perl

Cell· November 2014

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Baseline levels and temporal stability of 27 multiplexed serum cytokine concentrations in healthy subjects.
Angelique Biancotto, Abigail Wank, Shira Perl, Wendell Cook, Matthew J Olnes

PLoS One· September 2014

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Ultra-low dose interleukin-2 promotes immune-modulating function of regulatory T cells and natural killer cells in healthy volunteers.
Sawa Ito, Catherine M Bollard, Mattias Carlsten, Jan Joseph Melenhorst, Angélique Biancotto, Shira Perl

Mol Ther· July 2014

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Global analyses of human immune variation reveal baseline predictors of postvaccination responses.
John S Tsang, Pamela L Schwartzberg, Yuri Kotliarov, Angelique Biancotto, Zhi Xie, Shira Perl

Cell· April 2014

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Addition of rapamycin to anti-CD3 antibody improves long-term glycaemia control in diabetic NOD mice.
Shira Perl, Jordan Perlman, R P Weitzel, Oswald Phang, Matthew M Hsieh

PLoS One· February 2014

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Neurogenesis in the striatum of the adult human brain.
Aurélie Ernst, Kanar Alkass, Samuel Bernard, Mehran Salehpour, Shira Perl

Cell· February 2014

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