Publications by authors named "Shirit Einav"

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Discovery of antivirally active inhibitors of adaptor protein-2 associated kinase 1 based on various bicyclic heteroaromatic scaffolds derived from a 7-azaindole analogue.
Stijn Anthonissen, Wout Van Eynde, Marwah Karim, Ling-Jie Gao, Do Hoang Nhu Tran, Shirit Einav

Eur J Med Chem· December 2025

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Development of pyrazolo[1,5-a]pyrimidine based macrocyclic kinase inhibitors targeting AAK1.
Theresa E Mensing, Christian G Kurz, Jennifer A Amrhein, Theresa A L Ehret, Franziska Preuss, Shirit Einav

Eur J Med Chem· December 2025

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Comprehensive metabolomics combined with machine learning for the identification of SARS-CoV-2 and other viruses directly from upper respiratory samples.
Catherine A Hogan, Anthony T Le, Afraz Khan, LingHui David Su, ChunHong Huang, Shirit Einav

J Clin Microbiol· November 2025

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Scalable single-cell total RNA-seq reveals non-coding programs in immunity, infection, and brain development.
Alina Isakova, Stephen Quake, Daniel Liu, Ivana Cvijovic, Rahul Sinha, Shirit Einav

Res Sq· September 2025

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Structure-Activity Relationship Study of 3-Alkynyl-6-aryl-isothiazolo[4,3-]pyridines as Dual Inhibitors of the Lipid Kinases PIKfyve and PIP4K2C.
Demian Kalebic, Ling-Jie Gao, Belén Martinez-Gualda, Marwah Karim, Sirle Saul, Shirit Einav

Pharmaceuticals (Basel)· September 2025

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PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2.
Marwah Karim, Manjari Mishra, Chieh-Wen Lo, Sirle Saul, Halise Busra Cagirici, Shirit Einav

Nat Commun· July 2025

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Numb-associated kinases regulate sandfly-borne Toscana virus entry.
Yarden Moalem, Rodolfo Katz, Anand G Subramaniam, Yehonathan Malis, Yakey Yaffe, Shirit Einav

Emerg Microbes Infect· December 2024

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Synthesis of 3-heteroaryl-pyrrolo[2,3-b]pyridines as potent inhibitors of AP-2-associated protein kinase 1 (AAK1) with antiviral activity.
Nitha Panikkassery Ravi, Wout Van Eynde, Marwah Karim, Do Hoang Nhu Tran, Aditi Agrawal, Shirit Einav

Eur J Med Chem· December 2024

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Replication capacity and susceptibility of nirmatrelvir-resistant mutants to next-generation Mpro inhibitors in a SARS-CoV-2 replicon system.
Chieh-Wen Lo, Omri Kariv, Chenzhou Hao, Karen Anbro Gammeltoft, Jens Bukh, Shirit Einav

Antiviral Res· November 2024

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Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors.
Joshua Gerninghaus, Rezart Zhubi, Andreas Krämer, Marwah Karim, Do Hoang Nhu Tran, Shirit Einav

J Med Chem· August 2024

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PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2.
Marwah Karim, Manjari Mishra, Chieh-Wen Lo, Sirle Saul, Halise Busra Cagirici, Shirit Einav

bioRxiv· April 2024

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Chemical inactivation strategies for SARS-CoV-2-infected cells and organoids.
Marwah Karim, Amol Arunrao Pohane, Chieh-Wen Lo, Shirit Einav, Jaishree Garhyan

STAR Protoc· March 2024

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An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations.
Michael Westberg, Yichi Su, Xinzhi Zou, Pinghan Huang, Arjun Rustagi, Shirit Einav

Sci Transl Med· March 2024

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Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humans.
Kalani Ratnasiri, Hong Zheng, Jiaying Toh, Zhiyuan Yao, Veronica Duran, Shirit Einav

Cell Rep· February 2024

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Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity.
Joshua Gerninghaus, Rezart Zhubi, Andreas Krämer, Marwah Karim, Do Hoang Nhu Tran, Shirit Einav

bioRxiv· February 2024

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Global and cell type-specific immunological hallmarks of severe dengue progression identified via a systems immunology approach.
Luca Ghita, Zhiyuan Yao, Yike Xie, Veronica Duran, Halise Busra Cagirici, Shirit Einav

Nat Immunol· December 2023

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Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects.
Sirle Saul, Marwah Karim, Luca Ghita, Pei-Tzu Huang, Winston Chiu, Shirit Einav

J Clin Invest· October 2023

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Single B cell transcriptomics identifies multiple isotypes of broadly neutralizing antibodies against flaviviruses.
Jay Lubow, Lisa M Levoir, Duncan K Ralph, Laura Belmont, Maya Contreras, Shirit Einav

PLoS Pathog· October 2023

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Preparing for the next viral threat with broad-spectrum antivirals.
Marwah Karim, Chieh-Wen Lo, Shirit Einav

J Clin Invest· June 2023

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Single B cell transcriptomics identifies multiple isotypes of broadly neutralizing antibodies against flaviviruses.
Jay Lubow, Lisa M Levoir, Duncan K Ralph, Laura Belmont, Maya Contreras, Shirit Einav

bioRxiv· April 2023

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Magnitude and kinetics of the human immune cell response associated with severe dengue progression by single-cell proteomics.
Makeda L Robinson, David R Glass, Veronica Duran, Olga Lucia Agudelo Rojas, Ana Maria Sanz, Shirit Einav

Sci Adv· March 2023

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How can systems approaches help us understand and treat infectious disease?
Anna Kuchina, Jason Yang, Bree Aldridge, Kevin A Janes, Naeha Subramanian, Shirit Einav

Cell Syst· December 2022

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Synthesis and evaluation of 3-alkynyl-5-aryl-7-aza-indoles as broad-spectrum antiviral agents.
Belén Martinez-Gualda, Mirthe Graus, Anita Camps, Emiel Vanhulle, Sirle Saul, Shirit Einav

Front Chem· October 2022

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Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies.
Marwah Karim, Sirle Saul, Luca Ghita, Malaya Kumar Sahoo, Chengjin Ye, Shirit Einav

Antiviral Res· August 2022

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Nonlytic cellular release of hepatitis A virus requires dual capsid recruitment of the ESCRT-associated Bro1 domain proteins HD-PTP and ALIX.
Takayoshi Shirasaki, Hui Feng, Helen M E Duyvesteyn, William G Fusco, Kevin L McKnight, Shirit Einav

PLoS Pathog· August 2022

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