Publications by authors named "Shivan Sivakumar"

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Direct and bisulfite-free 5-methylcytosine and 5-hydroxymethylcytosine sequencing at single-cell resolution with scTAPS and scCAPS + .
Xiufei Chen, Jingfei Cheng, Linzhen Kong, Xiao Shu, Haiqi Xu, Shivan Sivakumar

Genome Biol· August 2025

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UK Real-World Evidence of Using Durvalumab Plus Cisplatin and Gemcitabine in Advanced Biliary Tract Cancer via an Early Access Scheme.
Harry Daniels, Mona Hassan, Omer Babiker, William Rowley, Aitzaz Qaisar, Shivan Sivakumar

Cancers (Basel)· August 2025

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Stroma and lymphocytes identified by deep learning are independent predictors for survival in pancreatic cancer.
Xiuxiang Tan, Mika Rosin, Simone Appinger, Julia Campello Deierl, Konrad Reichel, Shivan Sivakumar

Sci Rep· March 2025

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Distinct immune cell infiltration patterns in pancreatic ductal adenocarcinoma (PDAC) exhibit divergent immune cell selection and immunosuppressive mechanisms.
Shivan Sivakumar, Ashwin Jainarayanan, Edward Arbe-Barnes, Piyush Kumar Sharma, Maire Ni Leathlobhair, Pallavur V Sivakumar

Nat Commun· February 2025

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Tissue-resident natural killer cells support survival in pancreatic cancer through promotion of cDC1-CD8 T activity.
Simei Go, Constantinos Demetriou, Giampiero Valenzano, Sophie Hughes, Simone Lanfredini, Shivan Sivakumar

Elife· December 2024

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The microbial composition of pancreatic ductal adenocarcinoma: a systematic review of 16S rRNA gene sequencing.
Nabeel Merali, Tarak Chouari, Casie Sweeney, James Halle-Smith, Maria-Danae Jessel, Shivan Sivakumar

Int J Surg· October 2024

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MicroRNAs as Bile-based biomarkers in pancreaticobiliary cancers (MIRABILE): a cohort study.
Daniel S K Liu, Jisce R Puik, Morten T Venø, Mireia Mato Prado, Eleanor Rees, Shivan Sivakumar

Int J Surg· October 2024

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SIMAP500: A novel risk score to identify recipients at higher risk of hepatocellular carcinoma recurrence following liver transplantation.
Amr Alnagar, Nekisa Zakeri, Konstantinos Koilias, Rosemary E Faulkes, Rachel Brown, Shivan Sivakumar

World J Transplant· September 2024

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Impact of tertiary lymphoid structures on prognosis and therapeutic response in pancreatic ductal adenocarcinoma.
Nabeel Merali, Maria-Danae Jessel, Edward H Arbe-Barnes, Wing Yu Ruby Lee, Martha Gismondi, Shivan Sivakumar

HPB (Oxford)· July 2024

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Unlocking the diagnostic power of plasma extracellular vesicle miR-200 family in pancreatic ductal adenocarcinoma.
Daniel S K Liu, Jisce R Puik, Bhavik Y Patel, Morten T Venø, Mahrou Vahabi, Shivan Sivakumar

J Exp Clin Cancer Res· July 2024

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Predicting the risk of pancreatic cancer in adults with new-onset diabetes: development and internal-external validation of a clinical risk prediction model.
Ash Kieran Clift, Pui San Tan, Martina Patone, Weiqi Liao, Carol Coupland, Shivan Sivakumar

Br J Cancer· June 2024

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Manipulating regulatory T cells: is it the key to unlocking effective immunotherapy for pancreatic ductal adenocarcinoma?
Henry Smith, Edward Arbe-Barnes, Enas Abu Shah, Shivan Sivakumar

Front Immunol· June 2024

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Improving early diagnosis of pancreatic cancer in symptomatic patients.
Amber J Johnston, Shivan Sivakumar, Yin Zhou, Garth Funston, Stephen H Bradley

Br J Gen Pract· December 2023

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A bile-based microRNA signature for differentiating malignant from benign pancreaticobiliary disease.
Mireia Mato Prado, Jisce R Puik, Leandro Castellano, Elena López-Jiménez, Daniel S K Liu, Shivan Sivakumar

Exp Hematol Oncol· December 2023

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Bile Microbiome Signatures Associated with Pancreatic Ductal Adenocarcinoma Compared to Benign Disease: A UK Pilot Study.
Nabeel Merali, Tarak Chouari, Julien Terroire, Maria-Danae Jessel, Daniel S K Liu, Shivan Sivakumar

Int J Mol Sci· November 2023

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Clinical trial protocol for PanDox: a phase I study of targeted chemotherapy delivery to non-resectable primary pancreatic tumours using thermosensitive liposomal doxorubicin (ThermoDox®) and focused ultrasound.
Laura Spiers, Michael Gray, Paul Lyon, Shivan Sivakumar, Noor Bekkali

BMC Cancer· September 2023

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Advances in Immunotherapeutics in Pancreatic Ductal Adenocarcinoma.
Tarak Chouari, Francesca Soraya La Costa, Nabeel Merali, Maria-Danae Jessel, Shivan Sivakumar

Cancers (Basel)· August 2023

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Pseudotime dynamics of T cells in pancreatic ductal adenocarcinoma inform distinct functional states within the regulatory and cytotoxic T cells.
Ashwin Jainarayanan, Nithishwer Mouroug-Anand, Edward H Arbe-Barnes, Adam J Bush, Rachael Bashford-Rogers, Shivan Sivakumar

iScience· April 2023

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Temporality of body mass index, blood tests, comorbidities and medication use as early markers for pancreatic ductal adenocarcinoma (PDAC): a nested case-control study.
Pui San Tan, Cesar Garriga, Ashley Clift, Weiqi Liao, Martina Patone, Shivan Sivakumar

Gut· March 2023

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Expression of Checkpoint Molecules in the Tumor Microenvironment of Intrahepatic Cholangiocarcinoma: Implications for Immune Checkpoint Blockade Therapy.
Lara Heij, Jan Bednarsch, Xiuxiang Tan, Mika Rosin, Simone Appinger, Shivan Sivakumar

Cells· March 2023

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Editorial on "".
Shivan Sivakumar, Flavio G Rocha, Lara Heij

Hepatobiliary Surg Nutr· June 2022

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Healthcare systems must get fair value for their data.
Stephen H Bradley, Scott Hemphill, Sarah Markham, Shivan Sivakumar

BMJ· June 2022

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The COVID-19 Pandemic Is Associated with Reduced Survival after Pancreatic Ductal Adenocarcinoma Diagnosis: A Single-Centre Retrospective Analysis.
Oliver Madge, Alexandra Brodey, Jordan Bowen, George Nicholson, Shivan Sivakumar

J Clin Med· May 2022

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The 11th revision of the International Statistical Classification of Disease and Related Health Problems and Cholangiocarcinoma.
Shijie Cai, Shivan Sivakumar

Hepatobiliary Surg Nutr· April 2022

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PD-1+ T-Cells Correlate with Nerve Fiber Density as a Prognostic Biomarker in Patients with Resected Perihilar Cholangiocarcinoma.
Xiuxiang Tan, Jan Bednarsch, Mika Rosin, Simone Appinger, Dong Liu, Shivan Sivakumar

Cancers (Basel)· April 2022

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