Publications by authors named "Shivashankar Othy"

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Human CD4 T cells are a functional target for lipid nanoparticle-based mRNA vaccines.
Samuel C Kim, Jiin Felgner, Mariella S Soto, Lauren Hitchcock, Emily K Silzel, Timothy B Yates, Shivashankar Othy

mBio· November 2025

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Immune checkpoint inhibition perturbs neuro-immune homeostasis and impairs cognitive function.
Onwodi V Ifejeokwu, An H Do, Sanad M El Khatib, Nhu N Ho, Angel Zavala, Shivashankar Othy

J Exp Clin Cancer Res· July 2025

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Incidence and predictors of immune checkpoint inhibitor treatment-related cognitive impairment in a racial and ethnic diverse population.
Michael Sayer, Parisa Agrawal, Ding Quan Ng, Dalia Kagramanov, Julia Trudeau, Shivashankar Othy

Support Care Cancer· June 2025

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Immune Checkpoint Inhibition Perturbs Neuro-immune Homeostasis and Impairs Cognitive Function.
Onwodi V Ifejeokwu, An Do, Sanad M El Khatib, Nhu H Ho, Angel Zavala, Shivashankar Othy

Res Sq· April 2025

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Combination adjuvant improves influenza virus immunity by downregulation of immune homeostasis genes in lymphocytes.
Emmanuel Dollinger, Jenny Hernandez-Davies, Jiin Felgner, Aarti Jain, Michael Hwang, Shivashankar Othy

Immunohorizons· January 2025

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Protocol to quantify the activation dynamics of tumor-associated T cells in mice by functional intravital microscopy.
Shannon N Geels, Claire Murat, Alexander Moshensky, Shivashankar Othy, Francesco Marangoni

STAR Protoc· December 2024

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Polymodal K channel modulation contributes to dual analgesic and anti-inflammatory actions of traditional botanical medicines.
Rían W Manville, Ryan F Yoshimura, Andriy V Yeromin, Derk Hogenkamp, Jennifer van der Horst, Shivashankar Othy

Commun Biol· August 2024

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Immune Checkpoint Inhibition-related Neuroinflammation Disrupts Cognitive Function.
Onwodi V Ifejeokwu, An Do, Sanad M El Khatib, Nhu H Ho, Angel Zavala, Shivashankar Othy

bioRxiv· July 2024

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Interruption of the intratumor CD8 T cell:Treg crosstalk improves the efficacy of PD-1 immunotherapy.
Shannon N Geels, Alexander Moshensky, Rachel S Sousa, Claire Murat, Matias A Bustos, Shivashankar Othy

Cancer Cell· June 2024

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Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis.
Gerald Coulis, Diego Jaime, Christian Guerrero-Juarez, Jenna M Kastenschmidt, Philip K Farahat, Shivashankar Othy

Sci Adv· July 2023

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Interruption of the Intratumor CD8:Treg Crosstalk Improves the Efficacy of PD-1 Immunotherapy.
Shannon N Geels, Alexander Moshensky, Rachel S Sousa, Benjamin L Walker, Rima Singh, Shivashankar Othy

bioRxiv· May 2023

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Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis.
Gerald Coulis, Diego Jaime, Christian Guerrero-Juarez, Jenna M Kastenschmidt, Philip K Farahat, Shivashankar Othy

bioRxiv· April 2023

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Early stress-induced impaired microglial pruning of excitatory synapses on immature CRH-expressing neurons provokes aberrant adult stress responses.
Jessica L Bolton, Annabel K Short, Shivashankar Othy, Cassandra L Kooiker, Manlin Shao

Cell Rep· March 2022

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TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia.
Amit Jairaman, Amanda McQuade, Alberto Granzotto, You Jung Kang, Jean Paul Chadarevian, Shivashankar Othy

Elife· February 2022

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Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop.
Francesco Marangoni, Ademi Zhakyp, Michela Corsini, Shannon N Geels, Esteban Carrizosa, Shivashankar Othy

Cell· July 2021

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Piezo1 channels restrain regulatory T cells but are dispensable for effector CD4 T cell responses.
Amit Jairaman, Shivashankar Othy, Joseph L Dynes, Andriy V Yeromin, Angel Zavala

Sci Adv· July 2021

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Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing.
Hamza Atcha, Amit Jairaman, Jesse R Holt, Vijaykumar S Meli, Raji R Nagalla, Shivashankar Othy

Nat Commun· May 2021

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Regulatory T cells suppress Th17 cell Ca signaling in the spinal cord during murine autoimmune neuroinflammation.
Shivashankar Othy, Amit Jairaman, Joseph L Dynes, Tobias X Dong, Cornelia Tune

Proc Natl Acad Sci U S A· August 2020

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Calcium Dynamics in Astrocytes During Cell Injury.
Nicole M Wakida, Veronica Gomez-Godinez, Huayan Li, Jessica Nguyen, Edward K Kim, Shivashankar Othy

Front Bioeng Biotechnol· August 2020

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Regulatory T cells promote remyelination in the murine experimental autoimmune encephalomyelitis model of multiple sclerosis following human neural stem cell transplant.
Laura L McIntyre, Scott A Greilach, Shivashankar Othy, Ilse Sears-Kraxberger, Brian Wi

Neurobiol Dis· July 2020

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Cxcl17 mice develop exacerbated disease in a T cell-dependent autoimmune model.
Marcela Hernández-Ruiz, Shivashankar Othy, Carolina Herrera, Hong-Tam Nguyen, Gerardo Arrevillaga-Boni

J Leukoc Biol· May 2019

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Intermittent Ca signals mediated by Orai1 regulate basal T cell motility.
Tobias X Dong, Shivashankar Othy, Milton L Greenberg, Amit Jairaman, Chijioke Akunwafo

Elife· December 2017

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T-cell calcium dynamics visualized in a ratiometric tdTomato-GCaMP6f transgenic reporter mouse.
Tobias X Dong, Shivashankar Othy, Amit Jairaman, Jonathan Skupsky, Angel Zavala

Elife· December 2017

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Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming.
Melanie P Matheu, Shivashankar Othy, Milton L Greenberg, Tobias X Dong, Martijn Schuijs

Nat Commun· February 2015

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Sialylation may be dispensable for reciprocal modulation of helper T cells by intravenous immunoglobulin.
Shivashankar Othy, Selma Topçu, Chaitrali Saha, Prathap Kothapalli, Sebastien Lacroix-Desmazes

Eur J Immunol· July 2014

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