Publications by authors named "Shoko Okazaki"

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Pharmacokinetic Analysis of Compounds Instilled into the Mouse Lung: Study with Electron Spin Resonance Spectroscopy and Nitroxyl Spin Probes as Model Drugs.
Jin-Yi Han, Keizo Takeshita, Shoko Okazaki, Hideo Utsumi

J Aerosol Med Pulm Drug Deliv· September 2025

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Utilization of the nitroxyl radical TEMPOL to assess scavenging activities of lipid-soluble antioxidants against radicals initiated by the thermal decomposition of 2,2'-azobis(2,4-dimethylvaleronitrile) (AMVN) in ethanol.
Keizo Takeshita, Ayaka Segawa, Kurumi Tokunaga, Ayaka Inamori, Ayako Matsuo, Shoko Okazaki

Free Radic Res· August 2025

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Development of an ESR-Based Diagnostic Probe for Matrix Metalloproteinase Activity Using a Spin-Labeled Peptide-Conjugated Styrene-Maleic Acid Copolymer.
Masato Sasaki, Kyouka Kato, Yuhei Ohta, Haruka Nakamura, Akihiko Kuniyasu, Shoko Okazaki

Biol Pharm Bull· July 2025

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Comparison of the accumulation manner of a macromolecular drug between two mouse tumour models: study with magnetic resonance imaging and the model macromolecular drug, gadolinium-conjugated dextran.
Keizo Takeshita, Yohei Nakagawa, Eika Yokoyama, Nana Shinohara, Kayoko Miura, Shoko Okazaki

J Drug Target· February 2025

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[Mechanistic Analysis of Oxidative Stress-related Diseases Using Nitroxyl Radicals and Electron Spin Resonance].
Shoko Okazaki

Yakugaku Zasshi· April 2024

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Convenient Application of a Compact-Type Magnetic Resonance Imager with Blood Pool Contrast Agent Gadolinium-Conjugated Dextran to Assess Vascular Abnormalities in Experimental Animals.
Keizo Takeshita, Risa Sawada, Kotaro Ishizaka, Ryoya Maki, Yuta Sakamoto, Shoko Okazaki

Biol Pharm Bull· May 2023

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Protective effects of 2-aminoethylthiosulfuric acid and structurally analogous organosulfur compounds against ionizing radiation.
Keizo Takeshita, Megumi Ueno, Kaori Fujii-Aikawa, Shoko Okazaki, Yuhei Ohta

J Clin Biochem Nutr· March 2023

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The preparation and validation of chitosan tablets that rapidly disperse and disintegrate as an oral adsorbent in the treatment of lifestyle-related diseases.
Makoto Anraku, Yasuyuki Mizukai, Yuji Maezaki, Kazuo Kawano, Shoko Okazaki

Carbohydr Polym· February 2021

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Differences in pharmacokinetic behaviors of two lipophilic 3-substituted 2,2,5,5-tetramethylpyrrolidine-N-oxyl radicals, in vivo probes to assess the redox status in the brain using magnetic resonance techniques.
Keizo Takeshita, Hana Okazaki, Megumi Tsukamoto, Shoko Okazaki

Magn Reson Med· January 2021

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Radical reactions induced by ketoprofen in phospholipid membranes under ultraviolet light irradiation.
Shoko Okazaki, Ayako Hirata, Yusuke Shogomori, Megumi Takemoto, Takuro Nagata

J Photochem Photobiol B· January 2021

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In vivo ESR imaging of redox status in mice after X-ray irradiation, measured by acyl-protected hydroxylamine probe, ACP.
Keita Saito, Shoko Okazaki, Yoko Tachibana, Kazunori Anzai, Toshihiko Ozawa

Free Radic Biol Med· November 2020

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Synthesis, Aggregation Behavior, and Photodynamic Properties of a Water-Soluble Fulleropyrrolidine Bearing an N-PEG Pyridinium Unit.
Keiji Mizuki, Seigo Matsumoto, Taro Honda, Kouhei Maeda, Satoshi Toyama, Shoko Okazaki

Chem Pharm Bull (Tokyo)· May 2019

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Application of a Compact Magnetic Resonance Imaging System with 1.5 T Permanent Magnets to Visualize Release from and the Disintegration of Capsule Formulations in Vitro and in Vivo.
Keizo Takeshita, Shoko Okazaki, Kyosuke Shinada, Yuma Shibamoto

Biol Pharm Bull· May 2018

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Surface-deacetylated chitin nanofibers reinforced with a sulfobutyl ether β-cyclodextrin gel loaded with prednisolone as potential therapy for inflammatory bowel disease.
Ryo Tabuchi, Makoto Anraku, Daisuke Iohara, Takako Ishiguro, Shinsuke Ifuku, Shoko Okazaki

Carbohydr Polym· October 2017

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Pharmacokinetics of lipophilically different 3-substituted 2,2,5,5-tetramethylpyrrolidine-N-oxyl radicals frequently used as redox probes in in vivo magnetic resonance studies.
Keizo Takeshita, Shoko Okazaki, Yuriko Hirose

Free Radic Biol Med· August 2016

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An evaluation of novel biological activity in a crude extract from Hemerocallis fulva L. var. sempervirens M. Hotta.
Kazuaki Taguchi, Keishi Yamasaki, Hiroki Maesaki, Masahiro Tokuno, Shoko Okazaki

Nat Prod Res· February 2015

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Redox evaluation in sepsis model mice by the in vivo ESR technique using acyl-protected hydroxylamine.
Shoko Okazaki, Yoko Tachibana, Yukari Koga-Ogawa, Keizo Takeshita

Free Radic Biol Med· March 2014

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Nitroxyl radicals remarkably enhanced the superoxide anion radical-induced chemiluminescence of Cypridina luciferin analogues.
Keizo Takeshita, Shoko Okazaki, Akiko Itoda

Anal Chem· July 2013

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Simple method for quantification of gadolinium magnetic resonance imaging contrast agents using ESR spectroscopy.
Keizo Takeshita, Shota Kinoshita, Shoko Okazaki

Chem Pharm Bull (Tokyo)· May 2012

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Effect of cholesterol on distribution of stable, hydrophobic perchlorotriphenylmethyl triethylester radical incorporated in lecithin liposomal membranes.
Keizo Takeshita, Shoko Okazaki, Hisao Kansui

Chem Pharm Bull (Tokyo)· August 2011

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Heterogeneity of regional redox status and relation of the redox status to oxygenation in a tumor model, evaluated using electron paramagnetic resonance imaging.
Keizo Takeshita, Kumiko Kawaguchi, Kaori Fujii-Aikawa, Megumi Ueno, Shoko Okazaki

Cancer Res· May 2010

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A major peroxiredoxin-induced activation of Yap1 transcription factor is mediated by reduction-sensitive disulfide bonds and reveals a low level of transcriptional activation.
Tsuyoshi Tachibana, Shoko Okazaki, Asako Murayama, Akira Naganuma, Akio Nomoto

J Biol Chem· February 2009

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Polymeric micelles of zinc protoporphyrin for tumor targeted delivery based on EPR effect and singlet oxygen generation.
Arun K Iyer, Khaled Greish, Takahiro Seki, Shoko Okazaki, Jun Fang

J Drug Target· October 2007

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Enzymatic reduction-resistant nitroxyl spin probes with spirocyclohexyl rings.
Shoko Okazaki, Md Abdul Mannan, Keijiro Sawai, Toshiki Masumizu, Yozo Miura

Free Radic Res· October 2007

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Multistep disulfide bond formation in Yap1 is required for sensing and transduction of H2O2 stress signal.
Shoko Okazaki, Tsuyoshi Tachibana, Akira Naganuma, Nariyasu Mano, Shusuke Kuge

Mol Cell· August 2007

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