Publications by authors named "Shriya Deshmukh"

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Comparative analysis of patient-derived organoids and patient-derived xenografts as avatar models for predicting response to anti-cancer therapy.
Joan Miguel Romero, Jamie Magrill, Nikita Kalashnikov, Yi Zhen Luo, Owen J Chen, Shriya Deshmukh

medRxiv· August 2025

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IDH1/2 Mutations in Cancer: Unifying Insights and Unlocking Therapeutic Potential for Chondrosarcoma.
Shriya Deshmukh, Ciara Kelly, Gabriel Tinoco

Target Oncol· January 2025

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H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs.
Brian Krug, Bo Hu, Haifen Chen, Adam Ptack, Xiao Chen, Shriya Deshmukh

bioRxiv· November 2023

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Kabuki syndrome stem cell models reveal locus specificity of histone methyltransferase 2D (KMT2D/MLL4).
Malvin Jefri, Xin Zhang, Patrick S Stumpf, Li Zhang, Huashan Peng, Shriya Deshmukh

Hum Mol Genet· October 2022

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Oncohistones: a roadmap to stalled development.
Shriya Deshmukh, Adam Ptack, Brian Krug, Nada Jabado

FEBS J· March 2022

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Polycomb repressive complex 2 in the driver's seat of childhood and young adult brain tumours.
Brian Krug, Ashot S Harutyunyan, Shriya Deshmukh, Nada Jabado

Trends Cell Biol· October 2021

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DNA Polymerase and Mismatch Repair Exert Distinct Microsatellite Instability Signatures in Normal and Malignant Human Cells.
Jiil Chung, Yosef E Maruvka, Sumedha Sudhaman, Jacalyn Kelly, Nicholas J Haradhvala, Shriya Deshmukh

Cancer Discov· May 2021

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H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone.
Sima Khazaei, Nicolas De Jay, Shriya Deshmukh, Liam D Hendrikse, Wajih Jawhar

Cancer Discov· December 2020

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Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis.
Carol C L Chen, Shriya Deshmukh, Selin Jessa, Djihad Hadjadj, Véronique Lisi

Cell· December 2020

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H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2.
Siddhant U Jain, Andrew Q Rashoff, Samuel D Krabbenhoft, Dominik Hoelper, Truman J Do, Shriya Deshmukh

Mol Cell· November 2020

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Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression.
Siddhant U Jain, Sima Khazaei, Dylan M Marchione, Stefan M Lundgren, Xiaoshi Wang, Shriya Deshmukh

Proc Natl Acad Sci U S A· November 2020

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Entering the era of precision medicine in pediatric oncology.
Djihad Hadjadj, Shriya Deshmukh, Nada Jabado

Nat Med· November 2020

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Phenotype Driven Analysis of Whole Genome Sequencing Identifies Deep Intronic Variants that Cause Retinal Dystrophies by Aberrant Exonization.
Matteo Di Scipio, Erika Tavares, Shriya Deshmukh, Isabelle Audo, Kit Green-Sanderson

Invest Ophthalmol Vis Sci· August 2020

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The neurologist's role in disabling multiple sclerosis: A qualitative study of patient and care provider perspectives.
Jean-Pierre R Falet, Shriya Deshmukh, Abrar Al-Jassim, Gregory Sigler, Melanie Babinski

Mult Scler· June 2020

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Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas.
Brian Krug, Nicolas De Jay, Ashot S Harutyunyan, Shriya Deshmukh, Dylan M Marchione

Cancer Cell· September 2019

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Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas.
Brian Krug, Nicolas De Jay, Ashot S Harutyunyan, Shriya Deshmukh, Dylan M Marchione

Cancer Cell· May 2019

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PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism.
Siddhant U Jain, Truman J Do, Peder J Lund, Andrew Q Rashoff, Katharine L Diehl, Shriya Deshmukh

Nat Commun· May 2019

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H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis.
Ashot S Harutyunyan, Brian Krug, Haifen Chen, Simon Papillon-Cavanagh, Michele Zeinieh, Shriya Deshmukh

Nat Commun· March 2019

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Author Correction: Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome.
Tenzin Gayden, Fernando E Sepulveda, Dong-Anh Khuong-Quang, Jonathan Pratt, Elvis T Valera, Shriya Deshmukh

Nat Genet· January 2019

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Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome.
Tenzin Gayden, Fernando E Sepulveda, Dong-Anh Khuong-Quang, Jonathan Pratt, Elvis T Valera, Shriya Deshmukh

Nat Genet· December 2018

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Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers.
Adam Shlien, Brittany B Campbell, Richard de Borja, Ludmil B Alexandrov, Daniele Merico, Shriya Deshmukh

Nat Genet· March 2015

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