Publications by authors named "Shu Shimada"

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PAD2-Mediated Histone Citrullination Drives Tumor Progression by Enhancing Cell Proliferation and Modifying the Microenvironment in Pancreatic Cancer.
Kentaro Umemura, Yoshimitsu Akiyama, Shu Shimada, Megumi Hatano, Ayumi Kono

Mol Cancer Res· October 2025

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ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T cells in hepatocellular carcinoma.
Koya Yasukawa, Shu Shimada, Yoshimitsu Akiyama, Tomohiko Taniai, Yosuke Igarashi

Cell Rep Med· April 2025

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Delactylase effects of SIRT1 on a positive feedback loop involving the H19-glycolysis-histone lactylation in gastric cancer.
Shu Tsukihara, Yoshimitsu Akiyama, Shu Shimada, Megumi Hatano, Yosuke Igarashi

Oncogene· March 2025

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Identification and clinical implications of endogenous retrovirus elements suppressed by SETDB1 in hepatocellular carcinoma.
Yosuke Igarashi, Yoshimitsu Akiyama, Shu Shimada, Shuichi Watanabe, Megumi Hatano

JHEP Rep· March 2025

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Integrative transcriptome profiling elucidates molecular and immunovascular characteristics of macrotrabecular HCC.
Tomohiko Taniai, Shu Shimada, Yoshimitsu Akiyama, Megumi Hatano, Koya Yasukawa

Hepatology· February 2025

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The chronicles of hepatocellular carcinoma classification: Subtyping, modeling, and treatment.
Shu Shimada, Shinji Tanaka

Hepatology· February 2024

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Loss of KDM6B epigenetically confers resistance to lipotoxicity in nonalcoholic fatty liver disease-related HCC.
Megumi Hatano, Yoshimitsu Akiyama, Shu Shimada, Kohei Yagi, Keiichi Akahoshi

Hepatol Commun· October 2023

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RTP4 silencing provokes tumor-intrinsic resistance to immune checkpoint blockade in colorectal cancer.
Yudai Yamamoto, Shu Shimada, Yoshimitsu Akiyama, Shu Tsukihara, Raizo Sugimoto

J Gastroenterol· June 2023

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Loss of SFXN1 mitigates lipotoxicity and predicts poor outcome in non-viral hepatocellular carcinoma.
Kohei Yagi, Shu Shimada, Yoshimitsu Akiyama, Megumi Hatano, Daisuke Asano

Sci Rep· June 2023

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Identification of a novel target of SETD1A histone methyltransferase and the clinical significance in pancreatic cancer.
Takeshi Ishii, Yoshimitsu Akiyama, Shu Shimada, Ayano Kabashima, Daisuke Asano

Cancer Sci· February 2023

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Molecular targeted drugs, comprehensive classification and preclinical models for the implementation of precision immune oncology in hepatocellular carcinoma.
Shu Shimada, Shinji Tanaka

Int J Clin Oncol· July 2022

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cGAS-STING signaling encourages immune cell overcoming of fibroblast barricades in pancreatic cancer.
Ayano Kabashima, Yuki Matsuo, Saki Ito, Yoshimitsu Akiyama, Takeshi Ishii, Shu Shimada

Sci Rep· June 2022

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Genomic landscape of a mouse model of diffuse-type gastric adenocarcinoma.
Menghua Zhang, Itsuki Sugita, Daisuke Komura, Hiroto Katoh, Shu Shimada

Gastric Cancer· January 2022

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Inhibition of acid ceramidase elicits mitochondrial dysfunction and oxidative stress in pancreatic cancer cells.
Tomohiko Taniai, Yoshihiro Shirai, Yohta Shimada, Ryoga Hamura, Mitsuru Yanagaki, Shu Shimada

Cancer Sci· November 2021

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Intrinsic activation of β-catenin signaling by CRISPR/Cas9-mediated exon skipping contributes to immune evasion in hepatocellular carcinoma.
Masafumi Akasu, Shu Shimada, Ayano Kabashima, Yoshimitsu Akiyama, Masahiro Shimokawa

Sci Rep· August 2021

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Molecular and immunological paradigms of hepatocellular carcinoma: Special reference to therapeutic approaches.
Ayano Kabashima, Shu Shimada, Masahiro Shimokawa, Yoshimitsu Akiyama, Minoru Tanabe

J Hepatobiliary Pancreat Sci· January 2021

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Loss of miR-100 and miR-125b results in cancer stem cell properties through IGF2 upregulation in hepatocellular carcinoma.
Hyang Sook Seol, Yoshimitsu Akiyama, San-Eun Lee, Shu Shimada, Se Jin Jang

Sci Rep· December 2020

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Loss of ARID1A induces a stemness gene ALDH1A1 expression with histone acetylation in the malignant subtype of cholangiocarcinoma.
Jun Yoshino, Yoshimitsu Akiyama, Shu Shimada, Toshiro Ogura, Kosuke Ogawa

Carcinogenesis· July 2020

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Classification of primary liver cancer with immunosuppression mechanisms and correlation with genomic alterations.
Masashi Fujita, Rui Yamaguchi, Takanori Hasegawa, Shu Shimada, Koji Arihiro

EBioMedicine· March 2020

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Upregulation of cancer-associated gene expression in activated fibroblasts in a mouse model of non-alcoholic steatohepatitis.
Masahiro Asakawa, Michiko Itoh, Takayoshi Suganami, Takeru Sakai, Sayaka Kanai, Shu Shimada

Sci Rep· December 2019

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Loss of KDM6A characterizes a poor prognostic subtype of human pancreatic cancer and potentiates HDAC inhibitor lethality.
Shuichi Watanabe, Shu Shimada, Yoshimitsu Akiyama, Yoshiya Ishikawa, Toshiro Ogura

Int J Cancer· July 2019

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A new era for understanding genetic evolution of multistep carcinogenesis.
Shu Shimada, Shinji Tanaka

J Gastroenterol· July 2019

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Asymmetric dimethylation at histone H3 arginine 2 by PRMT6 in gastric cancer progression.
Keisuke Okuno, Yoshimitsu Akiyama, Shu Shimada, Masatoshi Nakagawa, Toshiro Tanioka

Carcinogenesis· March 2019

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A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors.
Hiroshi Fukamachi, Seon-Kyu Kim, Jiwon Koh, Hye Seung Lee, Yasushi Sasaki, Shu Shimada

J Exp Clin Cancer Res· March 2019

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Comprehensive molecular and immunological characterization of hepatocellular carcinoma.
Shu Shimada, Kaoru Mogushi, Yoshimitsu Akiyama, Takaki Furuyama, Shuichi Watanabe

EBioMedicine· February 2019

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