Publications by authors named "Shubham Upadhayay"

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Role of Fibroblast Growth Factors in Neurological Disorders: Insight into Therapeutic Approaches and Molecular Mechanisms.
Shubham Upadhayay, Divya Soni, Maanvi Dhureja, Pooja Temgire, Vishal Kumar

Mol Neurobiol· November 2025

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Mechanism-guided discovery of chromene-chalcone hybrids targeting PKM2 and microtubules for breast cancer therapy.
Madhurendra Kumar Katiyar, Shubham Upadhayay, Dinesh Prasad Jalli, Vaishnavi Kalmegh, Gaurav Joshi

Bioorg Chem· October 2025

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ML-based prediction to experimental validation: Development of dihydroquinazoline based multi-potent ligands as anti-Alzheimer's agents.
Kailash Jangid, Bharti Devi, Naveen Kumar, Shubham Upadhayay, Vinay Kumar

Comput Biol Med· September 2025

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Raloxifene and Fulvestrant Exert Antioxidant, Anti-Inflammatory, and Antiapoptotic Action Against Haloperidol-Induced Tardive Dyskinesia in Rats via Activation of the GPER1/PI3k/Akt/Nrf2/HO-1 Signaling Pathways.
Shubham Upadhayay, Divya Soni, Puneet Kumar

J Biochem Mol Toxicol· August 2025

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Auranofin-loaded chitosan-lipid hybrid nanoparticle protects against rotenone model of Parkinson's disease via modulation of GSK-3β/ Nrf2/HO-1 signaling.
Divya Soni, Yogesh Garg, Shubham Upadhayay, Amit Bhatia, Bushra Basir

Eur J Pharmacol· July 2025

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Elucidating the neuroprotective potential of arbutin in 3-NPA induced HD-like pathology: Insights from in silico, in vitro, and in vivo models.
Pooja Temgire, Richmond Arthur, Shubham Upadhayay, Sahil Arora, Gargi Kapatia

Behav Brain Res· April 2025

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G-Protein-Coupled Estrogen Receptor 1 (GPER1) Activation Mitigates Haloperidol-Induced Neurotoxicity in SHSY-5Y Cells and Improves Motor Functions in Adult Zebrafish.
Shubham Upadhayay, Vivek Uttam, Puneet Kumar

Neurochem Res· March 2025

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Design, synthesis and anticancer evaluation of 4-Substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines as dual topoisomerase I and II inhibitors.
Sahil Arora, Shubham Upadhayay, Pradeep Kumar, Puneet Kumar, Raj Kumar

Bioorg Chem· January 2025

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Glycyrrhizic Acid Mitigates Haloperidol-Induced Neurotoxicity in SHSY-5Y Cells and Rats Via Activation of PI3k/Akt/Nrf2 Pathways.
Mohammad Aqeel, Shubham Upadhayay, Ritika Devi, Kailash Jangid, Vinod Kumar

Neurochem Res· January 2025

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Crosstalk between gut-brain axis: unveiling the mysteries of gut ROS in progression of Parkinson's disease.
Divya Soni, Shubham Upadhayay, Maanvi Dhureja, Richmond Arthur, Puneet Kumar

Inflammopharmacology· October 2024

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Mitochondrial targeted antioxidants as potential therapy for huntington's disease.
Shubham Upadhayay, Puneet Kumar

Pharmacol Rep· August 2024

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In Vitro and In Vivo Investigations of Chromone Derivatives as Potential Multitarget-Directed Ligands: Cognitive Amelioration Utilizing a Scopolamine-Induced Zebrafish Model.
Naveen Kumar, Kailash Jangid, Vishal Kumar, Ravi Prakash Yadav, Jayapriya Mishra, Shubham Upadhayay

ACS Chem Neurosci· July 2024

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Impact of noscapine on halting the progression of pentylenetetrazole induced kindling epilepsy in mice.
Rishav Gupta, Divya Soni, Shubham Upadhayay, Maanvi Dhureja, Puneet Kumar

Clin Exp Pharmacol Physiol· December 2023

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Calcium channelopathies in neurodegenerative disorder: an untold story of RyR and SERCA.
Maanvi Dhureja, Richmond Arthur, Divya Soni, Shubham Upadhayay, Pooja Temgire

Expert Opin Ther Targets· December 2023

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Bacillus Calmette-Guérin Vaccine Attenuates Haloperidol-Induced TD-like Behavioral and Neurochemical Alteration in Experimental Rats.
Narhari Gangaram Yedke, Shubham Upadhayay, Randhir Singh, Sumit Jamwal, Sheikh F Ahmad

Biomolecules· November 2023

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Involvement of the G-Protein-Coupled Estrogen Receptor-1 (GPER) Signaling Pathway in Neurodegenerative Disorders: A Review.
Shubham Upadhayay, Rishav Gupta, Surbhi Singh, Maroti Mundkar, Gursewak Singh

Cell Mol Neurobiol· July 2023

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An Overview of the Pathophysiological Mechanisms of 3-Nitropropionic Acid (3-NPA) as a Neurotoxin in a Huntington's Disease Model and Its Relevance to Drug Discovery and Development.
Shubham Upadhayay, Narhari Gangaram Yedke, Vikrant Rahi, Surbhi Singh, Sachin Kumar

Neurochem Res· June 2023

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Animal models of Huntington's disease and their applicability to novel drug discovery and development.
Shubham Upadhayay, Sumit Jamwal, Puneet Kumar

Expert Opin Drug Discov· May 2023

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Monkeypox infection: The past, present, and future.
Shubham Upadhayay, Richmond Arthur, Divya Soni, Poonam Yadav, UmaShanker Navik

Int Immunopharmacol· December 2022

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Nrf2/HO-1 Signaling Stimulation through Acetyl-11-Keto-Beta-Boswellic Acid (AKBA) Provides Neuroprotection in Ethidium Bromide-Induced Experimental Model of Multiple Sclerosis.
Shubham Upadhayay, Sidharth Mehan, Aradhana Prajapati, Pranshul Sethi, Manisha Suri

Genes (Basel)· July 2022

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Inhibition of extracellular regulated kinase (ERK)-1/2 signaling pathway in the prevention of ALS: Target inhibitors and influences on neurological dysfunctions.
Rakesh Sahu, Shubham Upadhayay, Sidharth Mehan

Eur J Cell Biol· January 2022

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Nrf2/HO-1 Signaling Activator Acetyl-11-keto-beta Boswellic Acid (AKBA)-Mediated Neuroprotection in Methyl Mercury-Induced Experimental Model of ALS.
Elizabeth Minj, Shubham Upadhayay, Sidharth Mehan

Neurochem Res· November 2021

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Neuroprotective efficacy of 4-Hydroxyisoleucine in experimentally induced intracerebral hemorrhage.
Ehraz Mehmood Siddiqui, Sidharth Mehan, Shubham Upadhayay, Andleeb Khan, Maryam Halawi

Saudi J Biol Sci· November 2021

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Understanding Abnormal c-JNK/p38MAPK Signaling Overactivation Involved in the Progression of Multiple Sclerosis: Possible Therapeutic Targets and Impact on Neurodegenerative Diseases.
Anshuman Singh, Shubham Upadhayay, Sidharth Mehan

Neurotox Res· October 2021

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