Publications by authors named "Shuchi Agrawal-Singh"

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CREBBP inactivation sensitizes B cell acute lymphoblastic leukemia to ferroptotic cell death upon BCL2 inhibition.
Alicia Garcia-Gimenez, Jonathan E Ditcham, Dhoyazan M A Azazi, George Giotopoulos, Ryan Asby, Shuchi Agrawal-Singh

Nat Commun· May 2025

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Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 coactivation.
Viral Shah, George Giotopoulos, Hikari Osaki, Markus Meyerhöfer, Eshwar Meduri, Shuchi Agrawal-Singh

Blood· February 2025

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A guide to epigenetics in leukaemia stem cells.
Shuchi Agrawal-Singh, Jaana Bagri, Nathalie Sakakini, Brian J P Huntly

Mol Oncol· December 2023

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HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia.
Shuchi Agrawal-Singh, Jaana Bagri, George Giotopoulos, Dhoyazan M A Azazi, Sarah J Horton

Blood· April 2023

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Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression.
Haiyang Yun, Nisha Narayan, Shabana Vohra, George Giotopoulos, Annalisa Mupo, Shuchi Agrawal-Singh

Nat Genet· October 2021

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Histone deacetylase 4 promotes type I interferon signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6.
Yongxu Lu, Jennifer H Stuart, Callum Talbot-Cooper, Shuchi Agrawal-Singh, Brian Huntly

Proc Natl Acad Sci U S A· June 2019

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PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells.
Shuchi Agrawal Singh, Mads Lerdrup, Ana-Luisa R Gomes, Harmen Jg van de Werken, Jens Vilstrup Johansen

Elife· January 2019

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Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia.
Stefanie Göllner, Thomas Oellerich, Shuchi Agrawal-Singh, Tino Schenk, Hans-Ulrich Klein

Nat Med· January 2017

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An interactive environment for agile analysis and visualization of ChIP-sequencing data.
Mads Lerdrup, Jens Vilstrup Johansen, Shuchi Agrawal-Singh, Klaus Hansen

Nat Struct Mol Biol· April 2016

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The lncRNA MIR31HG regulates p16(INK4A) expression to modulate senescence.
Marta Montes, Morten M Nielsen, Giulia Maglieri, Anders Jacobsen, Jonas Højfeldt, Shuchi Agrawal-Singh

Nat Commun· April 2015

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DNA methylation changes are a late event in acute promyelocytic leukemia and coincide with loss of transcription factor binding.
Till Schoofs, Christian Rohde, Katja Hebestreit, Hans-Ulrich Klein, Stefanie Göllner, Shuchi Agrawal-Singh

Blood· January 2013

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REST-mediated recruitment of polycomb repressor complexes in mammalian cells.
Nikolaj Dietrich, Mads Lerdrup, Eskild Landt, Shuchi Agrawal-Singh, Mads Bak

PLoS Genet· September 2012

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Genome-wide analysis of histone H3 acetylation patterns in AML identifies PRDX2 as an epigenetically silenced tumor suppressor gene.
Shuchi Agrawal-Singh, Fabienne Isken, Konstantin Agelopoulos, Hans-Ulrich Klein, Nils H Thoennissen

Blood· March 2012

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Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling.
Nicole Bäumer, Lara Tickenbrock, Petra Tschanter, Lisa Lohmeyer, Sven Diederichs, Shuchi Agrawal-Singh

J Biol Chem· August 2011

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Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia.
Carsten Müller-Tidow, Hans-Ulrich Klein, Antje Hascher, Fabienne Isken, Lara Tickenbrock, Shuchi Agrawal-Singh

Blood· November 2010

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Polycomb group protein displacement and gene activation through MSK-dependent H3K27me3S28 phosphorylation.
Simmi Suman Gehani, Shuchi Agrawal-Singh, Nikolaj Dietrich, Nicolaj Strøyer Christophersen, Kristian Helin

Mol Cell· September 2010

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Pim2 cooperates with PML-RARalpha to induce acute myeloid leukemia in a bone marrow transplantation model.
Shuchi Agrawal-Singh, Steffen Koschmieder, Sandra Gelsing, Carol Stocking, Martin Stehling

Blood· June 2010

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