Publications by authors named "Shugui Chen"

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Structure and Functional Characterization of a Humanized Anti-CCL20 Antibody following Exposure to Serum Reveals the Formation of Immune Complex That Leads to Toxicity.
Andrew S Thomson, Shing H Mai, Gerben Bouma, Michael Herdman, Michael Byrne, Shugui Chen

J Immunol· March 2021

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Immune complex disease in a chronic monkey study with a humanised, therapeutic antibody against CCL20 is associated with complement-containing drug aggregates.
Susan B Laffan, Andrew S Thomson, Shing Mai, Cindy Fishman, Takahito Kambara, Shugui Chen

PLoS One· July 2020

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Biotherapeutic Antibody Subunit LC-MS and Peptide Mapping LC-MS Measurements to Study Possible Biotransformation and Critical Quality Attributes In Vivo.
John F Kellie, Andrew S Thomson, Shugui Chen, Sarah L Childs, Molly Z Karlinsey

J Pharm Sci· April 2019

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Artificial strain of human prions created in vitro.
Chae Kim, Xiangzhu Xiao, Shugui Chen, Tracy Haldiman, Vitautas Smirnovas

Nat Commun· June 2018

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Structural determinants of phenotypic diversity and replication rate of human prions.
Jiri G Safar, Xiangzhu Xiao, Mohammad E Kabir, Shugui Chen, Chae Kim, Wei Chen

PLoS Pathog· April 2015

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Interaction between prion protein and Aβ amyloid fibrils revisited.
Krzysztof Nieznanski, Krystyna Surewicz, Shugui Chen, Hanna Nieznanska, Witold K Surewicz

ACS Chem Neurosci· May 2014

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Conformational stability of mammalian prion protein amyloid fibrils is dictated by a packing polymorphism within the core region.
Nathan J Cobb, Marcin I Apostol, Shugui Chen, Vytautas Smirnovas, Witold K Surewicz

J Biol Chem· January 2014

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The effect of β2-α2 loop mutation on amyloidogenic properties of the prion protein.
Arpana Dutta, Shugui Chen, Witold K Surewicz

FEBS Lett· September 2013

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Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors.
Shoghag Panjarian, Roxana E Iacob, Shugui Chen, Thomas E Wales, John R Engen

J Biol Chem· March 2013

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Structure and dynamic regulation of Abl kinases.
Shoghag Panjarian, Roxana E Iacob, Shugui Chen, John R Engen, Thomas E Smithgall

J Biol Chem· February 2013

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Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry.
John R Engen, Thomas E Wales, Shugui Chen, Elaine M Marzluff, Kerry M Hassell

Int Rev Phys Chem· January 2013

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Soluble prion protein inhibits amyloid-β (Aβ) fibrillization and toxicity.
Krzysztof Nieznanski, Jin-Kyu Choi, Shugui Chen, Krystyna Surewicz, Witold K Surewicz

J Biol Chem· September 2012

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Structural polymorphism in amyloids: new insights from studies with Y145Stop prion protein fibrils.
Eric M Jones, Bo Wu, Krystyna Surewicz, Philippe S Nadaud, Jonathan J Helmus, Shugui Chen

J Biol Chem· December 2011

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Interaction between human prion protein and amyloid-beta (Abeta) oligomers: role OF N-terminal residues.
Shugui Chen, Satya P Yadav, Witold K Surewicz

J Biol Chem· August 2010

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PrP conformational transitions alter species preference of a PrP-specific antibody.
Wen-Quan Zou, Jan Langeveld, Xiangzhu Xiao, Shugui Chen, Patrick L McGeer

J Biol Chem· April 2010

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Tyrosine phosphorylation in the SH3 domain disrupts negative regulatory interactions within the c-Abl kinase core.
Shugui Chen, Linda P O'Reilly, Thomas E Smithgall, John R Engen

J Mol Biol· November 2008

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Abl N-terminal cap stabilization of SH3 domain dynamics.
Shugui Chen, Teodora Pene Dumitrescu, Thomas E Smithgall, John R Engen

Biochemistry· May 2008

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The Abl SH2-kinase linker naturally adopts a conformation competent for SH3 domain binding.
Shugui Chen, Sébastien Brier, Thomas E Smithgall, John R Engen

Protein Sci· April 2007

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