Publications by authors named "Shuo-Bin Chen"

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Design and evaluation of an HSP70-targeting PROTAC in synergy with an HSF1 inhibitor for enhanced antitumor activity.
Wei-Hao Huang, Teng-Yu Mao, Guo-Yao Dai, Jian-Mei Ye, Jia-Bao Li, Shuo-Bin Chen

RSC Med Chem· November 2025

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A small molecule targets LIC1 to suppress lung tumor growth by inducing autophagy.
Jia-Luo Huang, Lei-Ming Wu, Shu-Qi Wu, Fang-Yu Yuan, Han-Zhuang Weng, Shuo-Bin Chen

Nat Chem Biol· October 2025

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Identification of Indoquinazoline Derivatives as Novel NR4A1 Agonists by Suppressing Adipocyte Lipogenesis for Treatment of Obesity.
Yu-Tao Hu, Jia-Chun Luo, Shu-Min Xu, Zhi Jiang, Yu-Wei Lin, Shuo-Bin Chen

J Med Chem· August 2025

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An Aggregation/Monomer-Based Probe for Monitoring Mitochondria-Lysosome Interactions during Cuproptosis.
Cui Zhou, Jia-Tong Yan, Yi-Ting Chu, Jian Wang, Gui-Xue Tang, Shuo-Bin Chen, Xiu-Cai Chen

Anal Chem· July 2025

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From Theophylline to Adenine or preQ: Repurposing a DNA Aptamer Revealed by Crystal Structure Analysis.
Xiaowei Lin, Yuanyin Huang, Jinchao Huang, Hao Yuan, Yuhang Luo, Shuo-Bin Chen

Angew Chem Int Ed Engl· May 2025

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Synergistic anticancer activity of HSP70 and HSF1 inhibitors in colorectal cancer cells: A new strategy for combination therapy.
Shu-Min Xu, Xing-Zi Liu, Lu Wang, Wei-Hao Huang, Yu-Tao Hu, Shuo-Bin Chen

Biochim Biophys Acta Mol Basis Dis· March 2025

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Deciphering Phase-Separated Mitochondrial RNA Granules under Stress Conditions with the Mitoribosome-Targeting Small Molecule.
Gui-Xue Tang, Shu-Tang Zeng, Jian Wang, Jia-Tong Yan, Shuo-Bin Chen, Xiu-Cai Chen

Anal Chem· March 2025

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L-aspartate ameliorates diet-induced obesity by increasing adipocyte energy expenditure.
Shi-Yao Guo, Yu-Tao Hu, Yong Rao, Zhi Jiang, Chan Li, Shuo-Bin Chen

Diabetes Obes Metab· February 2025

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Specific Monitoring the DNA Helicase Function via Anchor-Embedded DNA Probe.
Keni Ning, Xiaoyan Tang, Zhe Li, Liting Zhong, Yingchen Zhou, Shuo-Bin Chen

Adv Sci (Weinh)· February 2025

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Derailment of the Biosynthesis via an Acid-Mediated Intramolecular Cyclo-rearrangement Leads to a Novel Cytochalasin Skeleton.
Chenran Xu, Yao-Hui Shi, Wenjun Zhang, Jiafan Yang, Xiufeng Zhang, Shuo-Bin Chen

J Nat Prod· February 2025

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RNA G-quadruplex structure-based PROTACs for targeted DHX36 protein degradation and gene activity modulation in mammalian cells.
Kun Zhang, Qichang Nie, Maolin Li, Xiaona Chen, Liting Zhong, Shuo-Bin Chen

Nucleic Acids Res· January 2025

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Disrupting the protein-protein interaction network of Hsp72 inhibits adipogenic differentiation and lipid synthesis in adipocytes.
Yu-Tao Hu, Yu-Wei Lin, Shi-Yao Guo, Zhi Jiang, Shu-Min Xu, Shuo-Bin Chen

Cell Signal· December 2024

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Identification of sanguinarine as c-MYC transcription inhibitor through enhancing the G-quadruplex-NM23-H2 interactions.
Li-Ting Zhong, Jing-Mei Yuan, Wen-Li Fu, Zi-Lin Zhang, Xiaoya Li, Shuo-Bin Chen

Bioorg Chem· December 2024

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Design, synthesis and structure-activity relationship of novel 2-pyrimidinylindole derivatives as orally available anti-obesity agents.
Li-Yuan Wei, Yu-Wei Lin, Jia-Chun Luo, Yi-Xian Li, Yu-Tao Hu, Shuo-Bin Chen

Eur J Med Chem· November 2024

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Mitochondrial RelA empowers mtDNA G-quadruplex formation for hypoxia adaptation in cancer cells.
Gui-Xue Tang, Mao-Lin Li, Cui Zhou, Zhi-Shu Huang, Shuo-Bin Chen, Xiu-Cai Chen

Cell Chem Biol· October 2024

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Development of Novel -Acylhydrazone Derivatives with High Anti-obesity Activity and Improved Safety by Exploring the Pharmaceutical Properties of Aldehyde Group.
Zhi Jiang, Yu-Tao Hu, Shi-Yao Guo, Yi-Xian Li, Dan-Dan Zhao, Shuo-Bin Chen

J Med Chem· July 2024

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Targeting ATP-binding site of WRN Helicase: Identification of novel inhibitors through pocket analysis and Molecular Dynamics-Enhanced virtual screening.
Hao Yuan, Run-Duo Liu, Zhuo-Yu Gao, Li-Ting Zhong, Ying-Chen Zhou, Shuo-Bin Chen

Bioorg Med Chem Lett· May 2024

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Constructing triazole-modified quinazoline derivatives as selective c-MYC G-quadruplex ligands and potent anticancer agents through click chemistry.
Jiong-Heng Cai, Dan-Yan Yang, Jun-Jie Zhang, Jia-Heng Tan, Zhi-Shu Huang, Shuo-Bin Chen

Bioorg Chem· March 2024

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Discovery of Novel Coumarin-quinolinium Derivatives as Pan-KRAS Translation Inhibitors by Targeting 5'-UTR RNA G-Quadruplexes.
Mao-Lin Li, Le-Tian Dai, Zhuo-Yu Gao, Jia-Tong Yan, Shu-Min Xu, Shuo-Bin Chen, Xiu-Cai Chen

J Med Chem· February 2024

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Design, synthesis and evaluation of 2-pyrimidinylindole derivatives as anti-obesity agents by regulating lipid metabolism.
Shi-Yao Guo, Li-Yuan Wei, Bing-Bing Song, Yu-Tao Hu, Zhi Jiang, Shuo-Bin Chen

Eur J Med Chem· November 2023

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Selective targeting of parallel G-quadruplex structure using L-RNA aptamer.
Danyang Ji, Jia-Hao Yuan, Shuo-Bin Chen, Jia-Heng Tan, Chun Kit Kwok

Nucleic Acids Res· November 2023

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Revealing Mitochondrion-Lysosome Dynamic Interactions and pH Variations in Live Cells with a pH-Sensitive Fluorescent Probe.
Jian Wang, Jia-Tong Yan, Shu-Tang Zeng, Wen Shao, Gui-Xue Tang, Shuo-Bin Chen, Xiu-Cai Chen

Anal Chem· November 2023

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Design and Synthesis of Bouchardatine Derivatives as a Novel AMP-Activated Protein Kinase Activator for the Treatment of Colorectal Cancer.
Yao-Hao Xu, Yu-Tao Hu, Shu-Min Xu, Bing-Bing Song, Hao Yuan, Shuo-Bin Chen

J Med Chem· June 2023

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A rapid and highly sensitive immunosorbent assay to monitor helicases unwinding diverse nucleic acid structures.
Jia-En Wang, Ying-Chen Zhou, Bi-Han Wu, Xiu-Cai Chen, Junqiu Zhai, Shuo-Bin Chen

Analyst· May 2023

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Development and Characterization of Benzoselenazole Derivatives as Potent and Selective Transcription Inhibitors.
Tian-Ying Wu, Xiu-Cai Chen, Gui-Xue Tang, Wen Shao, Zhang-Chi Li, Shuo-Bin Chen

J Med Chem· April 2023

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