Publications by authors named "Shuqun Lin"

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Identification of -Methyl Nicotinamide and -Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2).
Ryan Moslin, Yanlei Zhang, Stephen T Wrobleski, Shuqun Lin, Michael Mertzman, Dianlin Xie

J Med Chem· October 2019

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Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165.
Stephen T Wrobleski, Ryan Moslin, Shuqun Lin, Yanlei Zhang, Steven Spergel, Dianlin Xie

J Med Chem· October 2019

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Discovery and structure-based design of 4,6-diaminonicotinamides as potent and selective IRAK4 inhibitors.
Rajeev S Bhide, Alec Keon, Carolyn Weigelt, John S Sack, Robert J Schmidt, Shuqun Lin

Bioorg Med Chem Lett· November 2017

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Discovery of highly potent, selective, covalent inhibitors of JAK3.
James Kempson, Damaso Ovalle, Junqing Guo, Stephen T Wrobleski, Shuqun Lin

Bioorg Med Chem Lett· October 2017

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Discovery of ((4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl-2-(4-(phosphonooxy)phenyl)acetate (BMS-751324), a Clinical Prodrug of p38α MAP Kinase Inhibitor.
Chunjian Liu, James Lin, John Hynes, Hong Wu, Stephen T Wrobleski, Shuqun Lin, Rulin Zhao

J Med Chem· October 2015

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Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors.
James J-W Duan, Zhonghui Lu, Bin Jiang, Bingwei V Yang, Lidia M Doweyko, Shuqun Lin

Bioorg Med Chem Lett· December 2014

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The identification of novel p38α isoform selective kinase inhibitors having an unprecedented p38α binding mode.
Stephen T Wrobleski, Shuqun Lin, T G Murali Dhar, Alaric J Dyckman, Tianle Li

Bioorg Med Chem Lett· July 2013

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Utilization of a nitrogen-sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors.
Shuqun Lin, Stephen T Wrobleski, John Hynes, Sidney Pitt, Rosemary Zhang

Bioorg Med Chem Lett· October 2010

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Discovery of 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases.
Chunjian Liu, James Lin, Stephen T Wrobleski, Shuqun Lin, John Hynes

J Med Chem· September 2010

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Synthesis and SAR of new pyrrolo[2,1-f][1,2,4]triazines as potent p38 alpha MAP kinase inhibitors.
Stephen T Wrobleski, Shuqun Lin, John Hynes, Hong Wu, Sidney Pitt

Bioorg Med Chem Lett· April 2008

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Design, synthesis, and anti-inflammatory properties of orally active 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha mitogen-activated protein kinase inhibitors.
John Hynes, Alaric J Dyckman, Shuqun Lin, Stephen T Wrobleski, Hong Wu

J Med Chem· January 2008

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Synthesis and SAR of p38alpha MAP kinase inhibitors based on heterobicyclic scaffolds.
T G Murali Dhar, Stephen T Wrobleski, Shuqun Lin, Joseph A Furch, David S Nirschl

Bioorg Med Chem Lett· September 2007

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Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains.
Chen Zhao, Hing L Sham, Minghua Sun, Vincent S Stoll, Kent D Stewart, Shuqun Lin

Bioorg Med Chem Lett· December 2005

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The discovery of orally active triaminotriazine aniline amides as inhibitors of p38 MAP kinase.
Katerina Leftheris, Gulzar Ahmed, Ran Chan, Alaric J Dyckman, Zahid Hussain, Shuqun Lin, Tsung H Lin

J Med Chem· December 2004

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Rational design and synthesis of an orally active indolopyridone as a novel conformationally constrained cannabinoid ligand possessing antiinflammatory properties.
Stephen T Wrobleski, Ping Chen, John Hynes, Shuqun Lin, Derek J Norris

J Med Chem· May 2003

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