Publications by authors named "Siddharth Sunilkumar"

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Rapid proteasomal degradation of the stress response protein REDD2 is mediated by the E3 ligase HUWE1.
Ashley M VanCleave, Siddharth Sunilkumar, Christopher M McCurry, Allyson L Toro, Scot R Kimball

Biochem Biophys Res Commun· September 2025

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Deletion of the stress response protein REDD1 prevents sodium iodate-induced RPE damage and photoreceptor loss.
Sandeep M Subrahmanian, Esma I Yerlikaya, Siddharth Sunilkumar, Allyson L Toro, Christopher M McCurry

Geroscience· April 2025

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Podocyte-Specific Expression of the Stress Response Protein REDD1 Is Necessary for Diabetes-Induced Podocytopenia.
Siddharth Sunilkumar, Esma I Yerlikaya, Allyson L Toro, Han Chen, Yandong Zhou

Diabetes· March 2025

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REDD1-dependent GSK3β signaling in podocytes promotes canonical NF-κB activation in diabetic nephropathy.
Siddharth Sunilkumar, Esma I Yerlikaya, Ashley VanCleave, Sandeep M Subrahmanian, Allyson L Toro

J Biol Chem· March 2025

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REDD1 expression in podocytes facilitates renal inflammation and pyroptosis in streptozotocin-induced diabetic nephropathy.
Siddharth Sunilkumar, Sandeep M Subrahmanian, Esma I Yerlikaya, Allyson L Toro, Edward W Harhaj

Cell Death Dis· February 2025

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REDD1 Is a Promising Therapeutic Target to Combat the Development of Diabetes Complications: A Report on Research Supported by Pathway to Stop Diabetes.
Siddharth Sunilkumar, Michael D Dennis

Diabetes· October 2024

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REDD1 Deletion Suppresses NF-κB Signaling in Cardiomyocytes and Prevents Deficits in Cardiac Function in Diabetic Mice.
Shaunaci A Stevens, Siddharth Sunilkumar, Sandeep M Subrahmanian, Allyson L Toro, Omer Cavus

Int J Mol Sci· June 2024

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NLRP3 Inflammasome Priming in the Retina of Diabetic Mice Requires REDD1-Dependent Activation of GSK3β.
Christopher M McCurry, Siddharth Sunilkumar, Sandeep M Subrahmanian, Esma I Yerlikaya, Allyson L Toro

Invest Ophthalmol Vis Sci· March 2024

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REDD1-dependent GSK3β dephosphorylation promotes NF-κB activation and macrophage infiltration in the retina of diabetic mice.
Siddharth Sunilkumar, Ashley M VanCleave, Christopher M McCurry, Allyson L Toro, Shaunaci A Stevens

J Biol Chem· August 2023

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PERK/ATF4-dependent expression of the stress response protein REDD1 promotes proinflammatory cytokine expression in the heart of obese mice.
Shaunaci A Stevens, Maria K Gonzalez Aguiar, Allyson L Toro, Esma I Yerlikaya, Siddharth Sunilkumar

Am J Physiol Endocrinol Metab· January 2023

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Activation of Disulfide Redox Switch in REDD1 Promotes Oxidative Stress Under Hyperglycemic Conditions.
William P Miller, Congzhou M Sha, Siddharth Sunilkumar, Allyson L Toro, Ashley M VanCleave

Diabetes· December 2022

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Stress response protein REDD1 promotes diabetes-induced retinal inflammation by sustaining canonical NF-κB signaling.
Siddharth Sunilkumar, Allyson L Toro, Christopher M McCurry, Ashley M VanCleave, Shaunaci A Stevens

J Biol Chem· December 2022

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REDD1 Ablation Attenuates the Development of Renal Complications in Diabetic Mice.
Siddharth Sunilkumar, Esma I Yerlikaya, Allyson L Toro, William P Miller, Han Chen

Diabetes· November 2022

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Spleen Tyrosine Kinase Contributes to Müller Glial Expression of Proangiogenic Cytokines in Diabetes.
Esma I Yerlikaya, Allyson L Toro, Siddharth Sunilkumar, Ashley M VanCleave, Ming Leung

Invest Ophthalmol Vis Sci· October 2022

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Müller Glial Expression of REDD1 Is Required for Retinal Neurodegeneration and Visual Dysfunction in Diabetic Mice.
William P Miller, Allyson L Toro, Siddharth Sunilkumar, Shaunaci A Stevens, Ashley M VanCleave

Diabetes· May 2022

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Chrysin Ameliorates Cyclosporine-A-Induced Renal Fibrosis by Inhibiting TGF-β-Induced Epithelial-Mesenchymal Transition.
Rohan Reddy Nagavally, Siddharth Sunilkumar, Mumtaz Akhtar, Louis D Trombetta, Sue M Ford

Int J Mol Sci· September 2021

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Glucagon transiently stimulates mTORC1 by activation of an EPAC/Rap1 signaling axis.
Siddharth Sunilkumar, Scot R Kimball, Michael D Dennis

Cell Signal· August 2021

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The stress response protein REDD1 as a causal factor for oxidative stress in diabetic retinopathy.
William P Miller, Siddharth Sunilkumar, Michael D Dennis

Free Radic Biol Med· March 2021

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Retinol-binding protein 4 mRNA translation in hepatocytes is enhanced by activation of mTORC1.
Jaclyn E Welles, Allyson L Toro, Siddharth Sunilkumar, Shaunaci A Stevens, Carson J Purnell

Am J Physiol Endocrinol Metab· February 2021

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Diabetes enhances translation of mRNA in murine retinal Müller glia via a 4E-BP1/2-dependent mechanism.
Sadie K Dierschke, Allyson L Toro, William P Miller, Siddharth Sunilkumar, Michael D Dennis

J Biol Chem· July 2020

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Acetoacetate enhances oxidative metabolism and response to toxicants of cultured kidney cells.
Trudi Denoon, Siddharth Sunilkumar, Sue M Ford

Toxicol Lett· May 2020

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The stress response protein REDD1 promotes diabetes-induced oxidative stress in the retina by Keap1-independent Nrf2 degradation.
William P Miller, Siddharth Sunilkumar, Joseph F Giordano, Allyson L Toro, Alistair J Barber

J Biol Chem· May 2020

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Elevated glucose concentration in culture media decreases membrane trafficking of SGLT2 in LLC-PK cells via a cAMP/PKA-dependent pathway.
Siddharth Sunilkumar, Sue M Ford

Am J Physiol Cell Physiol· June 2019

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