Publications by authors named "Siglinde Wolf"

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Fragment-based library generation for the discovery of a peptidomimetic p53-Mdm4 inhibitor.
André Boltjes, Yijun Huang, Rob van de Velde, Laurie Rijkee, Siglinde Wolf

ACS Comb Sci· August 2014

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Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities.
Yijun Huang, Siglinde Wolf, Barbara Beck, Lisa-Maria Köhler, Kareem Khoury

ACS Chem Biol· March 2014

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Transient protein states in designing inhibitors of the MDM2-p53 interaction.
Michal Bista, Siglinde Wolf, Kareem Khoury, Kaja Kowalska, Yijun Huang

Structure· December 2013

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Benzimidazole-2-one: a novel anchoring principle for antagonizing p53-Mdm2.
Wei Wang, Haiping Cao, Siglinde Wolf, Miguel S Camacho-Horvitz, Tad A Holak

Bioorg Med Chem· July 2013

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Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists.
David Koes, Kareem Khoury, Yijun Huang, Wei Wang, Michal Bista, Siglinde Wolf

PLoS One· August 2012

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Exhaustive fluorine scanning toward potent p53-Mdm2 antagonists.
Yijun Huang, Siglinde Wolf, David Koes, Grzegorz M Popowicz, Carlos J Camacho

ChemMedChem· January 2012

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1,4-Thienodiazepine-2,5-diones via MCR (I): synthesis, virtual space and p53-Mdm2 activity.
Yijun Huang, Siglinde Wolf, Michal Bista, Lidio Meireles, Carlos Camacho

Chem Biol Drug Des· August 2010

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Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: p53/Hdm2 antagonists.
Anna Czarna, Barbara Beck, Stuti Srivastava, Grzegorz M Popowicz, Siglinde Wolf

Angew Chem Int Ed Engl· July 2010

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Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery.
Grzegorz M Popowicz, Anna Czarna, Siglinde Wolf, Kan Wang, Wei Wang

Cell Cycle· March 2010

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High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx.
Anna Czarna, Grzegorz M Popowicz, Aleksandra Pecak, Siglinde Wolf, Grzegorz Dubin

Cell Cycle· April 2009

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