Publications by authors named "Signe Fransen"

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Differential impact of test performance characteristics on burden-to-benefit tradeoffs for blood-based colorectal cancer screening: A microsimulation analysis.
Andrew Piscitello, Lauren N Carroll, Signe Fransen, Ben Wilson, Tarun Chandra

J Med Screen· December 2023

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Machine learning enables detection of early-stage colorectal cancer by whole-genome sequencing of plasma cell-free DNA.
Nathan Wan, David Weinberg, Tzu-Yu Liu, Katherine Niehaus, Eric A Ariazi, Signe Fransen

BMC Cancer· August 2019

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Minimal sequence variability of the region of HIV-1 integrase targeted by the Abbott RealTime HIV-1 viral load assay in clinical specimens with reduced susceptibility to raltegravir.
Thomas P Young, Laura A Napolitano, Agnes C Paquet, Neil T Parkin, Signe Fransen

J Virol Methods· November 2013

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Multiple genetic pathways involving amino acid position 143 of HIV-1 integrase are preferentially associated with specific secondary amino acid substitutions and confer resistance to raltegravir and cross-resistance to elvitegravir.
Wei Huang, Arne Frantzell, Signe Fransen, Christos J Petropoulos

Antimicrob Agents Chemother· September 2013

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Substitutions at amino acid positions 143, 148, and 155 of HIV-1 integrase define distinct genetic barriers to raltegravir resistance in vivo.
Signe Fransen, Soumi Gupta, Arne Frantzell, Christos J Petropoulos, Wei Huang

J Virol· July 2012

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Transmission of integrase strand-transfer inhibitor multidrug-resistant HIV-1: case report and response to raltegravir-containing antiretroviral therapy.
Benjamin Young, Signe Fransen, Kenneth S Greenberg, Amy Thomas, Sharon Martens

Antivir Ther· July 2011

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Connection domain mutations in HIV-1 reverse transcriptase do not impact etravirine susceptibility and virologic responses to etravirine-containing regimens.
Soumi Gupta, Johan Vingerhoets, Signe Fransen, Lotke Tambuyzer, Hilde Azijn

Antimicrob Agents Chemother· June 2011

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Performance of the Abbott RealTime HIV-1 viral load assay is not impacted by integrase inhibitor resistance-associated mutations.
Thomas P Young, Gavin Cloherty, Signe Fransen, Laura Napolitano, Priscilla Swanson

J Clin Microbiol· April 2011

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Mutational pathways and genetic barriers to CXCR4-mediated entry by human immunodeficiency virus type 1.
Wei Huang, Arne Frantzell, Jonathan Toma, Signe Fransen, Jeannette M Whitcomb

Virology· January 2011

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Evolution of integrase resistance during failure of integrase inhibitor-based antiretroviral therapy.
Hiroyu Hatano, Harry Lampiris, Signe Fransen, Soumi Gupta, Wei Huang

J Acquir Immune Defic Syndr· August 2010

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Combinations of mutations in the connection domain of human immunodeficiency virus type 1 reverse transcriptase: assessing the impact on nucleoside and nonnucleoside reverse transcriptase inhibitor resistance.
Soumi Gupta, Signe Fransen, Ellen E Paxinos, Eric Stawiski, Wei Huang

Antimicrob Agents Chemother· May 2010

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Loss of raltegravir susceptibility by human immunodeficiency virus type 1 is conferred via multiple nonoverlapping genetic pathways.
Signe Fransen, Soumi Gupta, Robert Danovich, Daria Hazuda, Michael Miller

J Virol· November 2009

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Longitudinal analysis of raltegravir susceptibility and integrase replication capacity of human immunodeficiency virus type 1 during virologic failure.
Signe Fransen, Marina Karmochkine, Wei Huang, Laurence Weiss, Christos J Petropoulos

Antimicrob Agents Chemother· October 2009

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Characterization of human immunodeficiency virus type 1 populations containing CXCR4-using variants from recently infected individuals.
Wei Huang, Jonathan Toma, Eric Stawiski, Signe Fransen, Terri Wrin

AIDS Res Hum Retroviruses· August 2009

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Suppression of dualtropic human immunodeficiency virus type 1 by the CXCR4 antagonist AMD3100 is associated with efficiency of CXCR4 use and baseline virus composition.
Signe Fransen, Gary Bridger, Jeannette M Whitcomb, Jonathan Toma, Eric Stawiski

Antimicrob Agents Chemother· July 2008

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Coreceptor tropism can be influenced by amino acid substitutions in the gp41 transmembrane subunit of human immunodeficiency virus type 1 envelope protein.
Wei Huang, Jonathan Toma, Signe Fransen, Eric Stawiski, Jacqueline D Reeves

J Virol· June 2008

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Coreceptor tropism in human immunodeficiency virus type 1 subtype D: high prevalence of CXCR4 tropism and heterogeneous composition of viral populations.
Wei Huang, Susan H Eshleman, Jonathan Toma, Signe Fransen, Eric Stawiski

J Virol· August 2007

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Development and characterization of a novel single-cycle recombinant-virus assay to determine human immunodeficiency virus type 1 coreceptor tropism.
Jeannette M Whitcomb, Wei Huang, Signe Fransen, Kay Limoli, Jonathan Toma

Antimicrob Agents Chemother· February 2007

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