Publications by authors named "Simeng Chen"

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Dissecting macrophage heterogeneity in ulcerative colitis: Single-cell analysis and functional validation of S100A4 as a therapeutic target.
Yuan Li, Yao Wang, Simeng Chen, Lijia Liu

Int Immunopharmacol· January 2026

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The regulatory network of antioxidant enzyme synergy in ROS homeostasis and Photosynthesis: Multilevel response mechanisms of rye seedlings under nicosulfuron-atrazine-freeze-thaw combined stress.
Yanan Xu, Guozhang Bao, Simeng Chen, Yue Yuan, Ning Li

Plant Physiol Biochem· December 2025

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Synthetic anticoagulant octaparin targets mitochondrial cardiolipin-GSDMD axis to rescue redox homeostasis in sepsis.
Shule Zhang, Cong Feng, Ning Yu, Rui Fang, Yingxin Zhang, Simeng Chen

Redox Biol· November 2025

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Freeze-Thaw Cycles Accelerate Plastic Pollution Invasion in Agriculture: Trojan Horse Effect of Microplastic-Plasticizer Contamination Revealed in Rye via Computational Chemistry and Multiomics.
Jinke Hu, Guozhang Bao, Jishun Wu, Simeng Chen, Yanan Xu

J Agric Food Chem· October 2025

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SDP-LIV1, a Novel and Optimized LIV-1 Antibody-drug Conjugate Demonstrating Superior Anti-Tumor Efficacy and Favorable Safety Profile for Treatment of Solid Tumors.
Yani Peng, Changyong Yang, Liwei Dong, Xing Sun, Wei Zheng, Simeng Chen, Cheng Liao

Mol Cancer Ther· September 2025

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Hyaluronic acid-functionalized PLGA nanoparticles loaded with circSNX6 siRNA overcome sunitinib resistance in renal cell carcinoma.
Yue Gao, Zhen Li, Xuelian Wang, Simeng Chen, Pengcheng Li

Biochem Biophys Res Commun· August 2025

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Hemoadhican-based self-leveling Janus patch for comprehensive prevention of postoperative adhesions.
Rui Fang, Ning Yu, Simeng Chen, Xi Xu, Jianfa Zhang

Mater Today Bio· August 2025

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Development of a Tumor-Specific Multivalent CD40 Agonist Antibody FAPxCD40 for Cancer Therapy: Balancing Efficacy and Toxicity.
Simeng Chen, Yuan Lin, Dan Li, Xiaoru Zhou, Xing Sun, Cheng Liao

Mol Cancer Ther· July 2025

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Causal effects of brain subregion gene expression on inflammatory bowel diseases revealed by Mendelian randomization and single cell analysis.
Yuan Li, Yao Wang, Simeng Chen, Lijia Liu

Sci Rep· July 2025

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Study on the interventional effect and molecular mechanism of HSP72 in regulating oxidative stress by watermelon seed peptide RDPEER.
Ziqi Yan, Simeng Chen, Chidimma Juliet Igbokwe, Yuqing Duan, Kai Hu

Food Chem· June 2025

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The key active ingredients identification and pharmacological mechanism investigation of extract of ethyl acetate from Er Miao San aganist rheumatoid arthritis.
Jia-Yu Wang, Ran Tang, Si-Meng Chen, Wen-Rui Su, Jin Wang

Fitoterapia· June 2025

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Exogenous γ-aminobutyric acid (GABA) effectively alleviates the synergistic inhibitory effect of freeze-thaw and copper combined stress on rye seedling growth.
Huixin Wang, Guozhang Bao, Lingzhi Tian, Simeng Chen, Yanan Xu

J Environ Manage· May 2025

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Assessment of the mechanism of combined toxicity of imidacloprid and triadimefon to Secale cereale L. seedlings under freeze-thaw cycle conditions.
Simeng Chen, Guozhang Bao, Yanan Xu, Huixin Wang, Lingzhi Tian

J Environ Manage· April 2025

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Plant polyphenols as natural bioactives for alleviating lipid metabolism disorder: Mechanisms and application challenges.
Haiying Wei, Jinsheng Rui, Xinke Yan, Ruyan Xu, Simeng Chen, Chengwen Zhu

Food Res Int· February 2025

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Knowledge mining of brain connectivity in massive literature based on transfer learning.
Xiaokang Chai, Sile An, Simeng Chen, Wenwei Li, Zhao Feng

Bioinformatics· November 2024

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Exogenous γ-aminobutyric acid (GABA) enhances rye () seedling resistance to combined freeze-thaw and cadmium stress.
Huixin Wang, Guozhang Bao, Lingzhi Tian, Simeng Chen, Yanan Xu

Funct Plant Biol· October 2024

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The landscape of miRNA-mRNA regulatory network and cellular sources in inflammatory bowel diseases: insights from text mining and single cell RNA sequencing analysis.
Yuan Li, Yao Wang, Simeng Chen, Lijia Liu

Front Immunol· September 2024

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A novel Sagittaria sagittifolia L. polysaccharides mitigate DSS-induced colitis via modulation of gut microbiota and MAPK/NF-κB signaling pathways.
Yuqin Feng, Simeng Chen, Yating Song, Shuhan Liu, Yuqing Duan

Int J Biol Macromol· January 2024

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Assessment of firefighter-training effectiveness in China based on human-factor parameters and machine learning.
Yang Li, Qinglin Han, Simeng Chen, Gaozhi Cui, Ke Bai

Technol Health Care· December 2023

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Wnt/β-catenin signaling pathway promotes abnormal activation of fibroblast-like synoviocytes and angiogenesis in rheumatoid arthritis and the intervention of Er Miao San.
Simeng Chen, Jin Wang, Jiayu Wang, Xiaoyi Jia, Zihua Xuan, Zhiluo Cheng

Phytomedicine· November 2023

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A specific visual-volumetric sensor for mercury ions based on smart hydrogel.
Shenghai Zhang, Wenzhong Qu, Simeng Chen, Dian Guo, Kaixi Xue

Analyst· November 2023

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RBC Transfusion Strategy in Oncological Patients with Chronic RBC Transfusion Therapy.
Weiwei Fang, Cheng Pang, Fanguo Zhang, Haipo Zhang, Tao Peng, Simeng Chen

Clin Lab· August 2023

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The prognostic effect of metastasis patterns on overall survival in organ metastatic lung adenocarcinoma.
Xiaowei Tie, Jin Wang, Yong Wang, Baobao Fu, Chenchen Wang, Simeng Chen

Medicine (Baltimore)· April 2023

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Xanthine dehydrogenase rewires metabolism and the survival of nutrient deprived lung adenocarcinoma cells by facilitating UPR and autophagic degradation.
Man-Man Chen, Wei Guo, Si-Meng Chen, Xiao-Zhen Guo, Lan Xu

Int J Biol Sci· February 2023

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Analysis of differential metabolites and metabolic pathways in adipose tissue of tree shrews (Tupaia belangeri) under gradient cooling acclimation.
Dongmin Hou, Huibao Chen, Ting Jia, Lin Zhang, Wenrong Gao, Simeng Chen

J Therm Biol· February 2023

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