Publications by authors named "Simon Cook"

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High frequency of moraine-dammed lake outburst floods driven by global warming.
Taigang Zhang, Weicai Wang, Ioannis Kougkoulos, Simon J Cook, Sihan Li

Nat Commun· December 2025

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Developing a weight-of-evidence methodology for persistence assessment of substances in the environment.
Christopher B Hughes, Megan Griffiths, Simon Cook, Dik van de Meent, John Parsons

Integr Environ Assess Manag· November 2025

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RAF inhibitors activate the integrated stress response by direct activation of GCN2.
Rebecca Gilley, Andrew M Kidger, Graham Neill, Eve Morrison, Paul Severson, Simon J Cook

Nat Commun· November 2025

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FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer.
Suzan Ber, Ming Yang, Marco Sciacovelli, Shamith Samarajiwa, Khushali Patel, Simon J Cook

EMBO Rep· November 2025

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NF-κB is a central regulator of hypoxia-induced gene expression.
Dilem Shakir, Michael Batie, Chun-Sui Kwok, Simon J Cook, Niall S Kenneth

EMBO Rep· November 2025

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Past and present bacterial communities in deglaciating northern latitude catchments reveal varied soil carbon sequestration potential.
Saule Akhmetkaliyeva, Andrew P Dean, Leon J Clarke, Simon J Cook, Sharon Ruiz Lopez

Sci Total Environ· March 2025

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Second MEK Inhibitor Shows Promise in Neurofibromatosis Type 1 With Symptomatic Plexiform Neurofibromas Signaling Hope for Other RASopathies.
Simon J Cook

J Clin Oncol· February 2025

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Hypoxia drives HIF2-dependent reversible macrophage cell cycle entry.
Bo Meng, Na Zhao, Petra Mlcochova, Isabella A T M Ferreira, Brian M Ortmann, Simon Cook

Cell Rep· July 2024

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EU-LIFE charter of independent life science research institutes.
Giulio Superti-Furga, Marta Agostinho, Jo Bury, Simon Cook, Christine Durinx

FEBS Lett· April 2024

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Reporter cell lines to screen for inhibitors or regulators of the KRAS-RAF-MEK1/2-ERK1/2 pathway.
Laura Weatherdon, Kate Stuart, Megan Cassidy, Alberto Moreno de la Gándara, Hanneke Okkenhaug, Simon J Cook

Biochem J· March 2024

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Outcome prediction in dogs admitted through the emergency room: Accuracy of staff prediction and comparison with an illness severity stratification system for hospitalized dogs.
Alice Le Gal, Dominic Martin Barfield, Roseanne Helen Wignall, Simon David Cook

J Vet Emerg Crit Care (San Antonio)· February 2024

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ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1.
Kathryn Balmanno, Andrew M Kidger, Dominic P Byrne, Matthew J Sale, Nejma Nassman, Simon J Cook

Biochem J· May 2023

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The development of an electronic geriatric assessment tool: Comprehensive health assessment for my plan (CHAMP).
Simon Cook, Cosmin Munteanu, Efthymios Papadopoulos, Howard Abrams, Jennifer N Stinson

J Geriatr Oncol· January 2023

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Retrospective evaluation of the use of small-bore wire-guided catheters for the management of peritoneal effusion in cats and dogs.
Jilli Crosby, Karen Humm, Simon D Cook

J Vet Emerg Crit Care (San Antonio)· January 2023

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Escape from G1 arrest during acute MEK inhibition drives the acquisition of drug resistance.
Prasanna Channathodiyil, Kieron May, Anne Segonds-Pichon, Paul D Smith, Simon J Cook

NAR Cancer· December 2022

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Perspectives of digital agriculture in diverse types of livestock supply chain systems. Making sense of uses and benefits.
Derek Baker, Elizabeth L Jackson, Simon Cook

Front Vet Sci· December 2022

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ERK5 Signalling and Resistance to ERK1/2 Pathway Therapeutics: The Path Less Travelled?
Simon J Cook, Pamela A Lochhead

Front Cell Dev Biol· July 2022

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The Impact of Over-The-Counter Lactic Acid Containing Vaginal Gels on the Integrity and Inflammatory State of the Vaginal Epithelium .
David Tyssen, Anna C Hearps, Kalyani Guntur, Lindi Masson, Simon Cook

Front Reprod Health· June 2022

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Retrospective evaluation of negative-pressure pulmonary edema in dogs (2006-2018): 35 cases.
Vicente J Herrería-Bustillo, Sophie Adamantos, Christopher R Lamb, Marta García-Arce, Emily Thomas, Simon Cook

J Vet Emerg Crit Care (San Antonio)· May 2022

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Medical and surgical management of pancreatic fluid accumulations in dogs: A retrospective study of 15 cases.
Charles T Talbot, Ring Cheung, Emma J Holmes, Simon D Cook

J Vet Intern Med· May 2022

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Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor.
Duncan C Miller, Tristan Reuillon, Lauren Molyneux, Timothy Blackburn, Simon J Cook

J Med Chem· May 2022

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IKKα plays a major role in canonical NF-κB signalling in colorectal cells.
Jack A Prescott, Kathryn Balmanno, Jennifer P Mitchell, Hanneke Okkenhaug, Simon J Cook

Biochem J· February 2022

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On-Farm Experimentation to transform global agriculture.
Myrtille Lacoste, Simon Cook, Matthew McNee, Danielle Gale, Julie Ingram

Nat Food· January 2022

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Accelerated mass loss of Himalayan glaciers since the Little Ice Age.
Ethan Lee, Jonathan L Carrivick, Duncan J Quincey, Simon J Cook, William H M James

Sci Rep· December 2021

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Healthcare providers' perception of faecal microbiota transplantation with clostridium difficile infection and inflammatory bowel disease: a quantitative systematic review.
Yanghua Liu, Kal Alnababtah, Simon Cook, Ying Yu

Therap Adv Gastroenterol· September 2021

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