Publications by authors named "Simon Dearden"

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Patterns of genomic instability in > 2000 patients with ovarian cancer across six clinical trials evaluating olaparib.
Alan Barnicle, Isabelle Ray-Coquard, Etienne Rouleau, Karen Cadoo, Fiona Simpkins, Simon Dearden

Genome Med· December 2024

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Identifying homologous recombination deficiency in breast cancer: genomic instability score distributions differ among breast cancer subtypes.
Lauren Lenz, Chris Neff, Cara Solimeno, Elizabeth S Cogan, Vandana G Abramson, Simon Dearden

Breast Cancer Res Treat· November 2023

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The landscape of BRCA1 and BRCA2 large rearrangements in an international cohort of over 20 000 ovarian tumors identified using next-generation sequencing.
Melanie A Jones, Kirsten M Timms, Shanell Hatcher, Elizabeth S Cogan, Matthew S Comeaux, Simon Dearden

Genes Chromosomes Cancer· October 2023

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Detection of BRCA1, BRCA2, and ATM Alterations in Matched Tumor Tissue and Circulating Tumor DNA in Patients with Prostate Cancer Screened in PROfound.
Kim N Chi, Alan Barnicle, Caroline Sibilla, Zhongwu Lai, Claire Corcoran, Simon Dearden

Clin Cancer Res· January 2023

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Olaparib Efficacy in Patients with Metastatic Castration-resistant Prostate Cancer and BRCA1, BRCA2, or ATM Alterations Identified by Testing Circulating Tumor DNA.
Nobuaki Matsubara, Johann de Bono, David Olmos, Giuseppe Procopio, Satoru Kawakami, Simon Dearden

Clin Cancer Res· January 2023

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Concordance of BRCA mutation detection in tumor versus blood, and frequency of bi-allelic loss of BRCA in tumors from patients in the phase III SOLO2 trial.
Darren R Hodgson, Jessica S Brown, Simon P Dearden, Zhongwu Lai, Cathy E Elks

Gynecol Oncol· December 2021

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Tissue and Plasma EGFR Mutation Analysis in the FLAURA Trial: Osimertinib versus Comparator EGFR Tyrosine Kinase Inhibitor as First-Line Treatment in Patients with EGFR-Mutated Advanced Non-Small Cell Lung Cancer.
Jhanelle E Gray, Isamu Okamoto, Virote Sriuranpong, Johan Vansteenkiste, Fumio Imamura, Simon Dearden

Clin Cancer Res· November 2019

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Analysis of head and neck carcinoma progression reveals novel and relevant stage-specific changes associated with immortalisation and malignancy.
Ratna Veeramachaneni, Thomas Walker, Timothée Revil, Antoine De Weck, Dunarel Badescu, Simon Dearden

Sci Rep· August 2019

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EGFR Mutation Analysis for Prospective Patient Selection in Two Phase II Registration Studies of Osimertinib.
Suzanne Jenkins, James Chih-Hsin Yang, Pasi A Jänne, Kenneth S Thress, Karen Yu, Simon Dearden

J Thorac Oncol· August 2017

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EGFR T790M mutation testing within the osimertinib AURA Phase I study.
Simon Dearden, Helen Brown, Suzanne Jenkins, Kenneth S Thress, Mireille Cantarini

Lung Cancer· July 2017

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EGFR mutation detection in ctDNA from NSCLC patient plasma: A cross-platform comparison of leading technologies to support the clinical development of AZD9291.
Kenneth S Thress, Roz Brant, T Hedley Carr, Simon Dearden, Suzanne Jenkins

Lung Cancer· December 2015

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EGFR mutation incidence in non-small-cell lung cancer of adenocarcinoma histology: a systematic review and global map by ethnicity (mutMapII).
Anita Midha, Simon Dearden, Rose McCormack

Am J Cancer Res· November 2015

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Mutation status concordance between primary lesions and metastatic sites of advanced non-small-cell lung cancer and the impact of mutation testing methodologies: a literature review.
James Sherwood, Simon Dearden, Marianne Ratcliffe, Jill Walker

J Exp Clin Cancer Res· September 2015

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Gefitinib treatment in EGFR mutated caucasian NSCLC: circulating-free tumor DNA as a surrogate for determination of EGFR status.
Jean-Yves Douillard, Gyula Ostoros, Manuel Cobo, Tudor Ciuleanu, Rebecca Cole, Simon Dearden

J Thorac Oncol· September 2014

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Identification of a subset of human non-small cell lung cancer patients with high PI3Kβ and low PTEN expression, more prevalent in squamous cell carcinoma.
Marie Cumberbatch, Ximing Tang, Garry Beran, Sonia Eckersley, Xin Wang, Simon Dearden

Clin Cancer Res· February 2014

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KRAS mutations are associated with inferior clinical outcome in patients with metastatic colorectal cancer, but are not predictive for benefit with cediranib.
John C Smith, Laura Brooks, Paulo M Hoff, Gael McWalter, Simon Dearden

Eur J Cancer· July 2013

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Validation of the BRCA1 antibody MS110 and the utility of BRCA1 as a patient selection biomarker in immunohistochemical analysis of breast and ovarian tumours.
Roy Milner, Helen Wombwell, Sonia Eckersley, Donna Barnes, Juli Warwicker, Simon Dearden

Virchows Arch· March 2013

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EGFR mutation testing in lung cancer: a review of available methods and their use for analysis of tumour tissue and cytology samples.
Gillian Ellison, Guanshan Zhu, Alexandros Moulis, Simon Dearden, Georgina Speake

J Clin Pathol· February 2013

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Pseudoautosomal linkage of familial Hodgkin's lymphoma: molecular analysis of a unique family with Leri-Weill dyschondrosteosis and Hodgkins lymphoma.
Deborah J Shears, Volker Endris, David A Gokhale, Simon P Dearden, John A Radford

Br J Haematol· April 2003

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Genetic susceptibility to childhood common acute lymphoblastic leukaemia is associated with polymorphic peptide-binding pocket profiles in HLA-DPB1*0201.
G Malcolm Taylor, Simon Dearden, Paul Ravetto, Michelle Ayres, Pamela Watson

Hum Mol Genet· July 2002

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