Publications by authors named "Simon Messner"

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Incorporating Patient Input into the Target Product Profile.
Jean-Noel Talabardon, Janet E Church, Masanori Okuse, Michaela Dinboeck, Sheila Dickinson, Simon Messner

Ther Innov Regul Sci· July 2025

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An Ethnographic Study of Patient Life Experience in Early-Stage Parkinson's Disease in the United States and Germany.
Todd Carmody, Rebekah Park, Elisabeth Bennett, Emily Kuret, Beyza Klein, Simon Messner

Neurol Ther· August 2024

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TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells.
Katia Schoeler, Andreas Aufschnaiter, Simon Messner, Emmanuel Derudder, Sebastian Herzog

FEBS J· September 2019

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Prediction of Safety Margin and Optimization of Dosing Protocol for a Novel Antibiotic using Quantitative Systems Pharmacology Modeling.
Jeffrey L Woodhead, Franziska Paech, Martina Maurer, Marc Engelhardt, Anne H Schmitt-Hoffmann, Simon Messner

Clin Transl Sci· September 2018

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Transcriptomic, Proteomic, and Functional Long-Term Characterization of Multicellular Three-Dimensional Human Liver Microtissues.
Simon Messner, Lisa Fredriksson, Volker M Lauschke, Katrin Roessger, Claudia Escher

Appl In Vitro Toxicol· March 2018

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Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072.
Franziska Paech, Simon Messner, Jochen Spickermann, Mathias Wind, Anne-Hortense Schmitt-Hoffmann

Arch Toxicol· November 2017

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Pro-fibrotic compounds induce stellate cell activation, ECM-remodelling and Nrf2 activation in a human 3D-multicellular model of liver fibrosis.
Vincenzo Prestigiacomo, Anna Weston, Simon Messner, Franziska Lampart, Laura Suter-Dick

PLoS One· October 2017

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Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury.
William R Proctor, Alison J Foster, Jennifer Vogt, Claire Summers, Brian Middleton, Simon Messner

Arch Toxicol· August 2017

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Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission.
Himanish Ghosh, Luca Auguadri, Sereina Battaglia, Zahra Simone Thirouin, Khaled Zemoura, Simon Messner

Nat Commun· November 2016

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Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability.
Delilah F G Hendriks, Lisa Fredriksson Puigvert, Simon Messner, Wolfgang Mortiz, Magnus Ingelman-Sundberg

Sci Rep· October 2016

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Extending the limits of quantitative proteome profiling with data-independent acquisition and application to acetaminophen-treated three-dimensional liver microtissues.
Roland Bruderer, Oliver M Bernhardt, Tejas Gandhi, Saša M Miladinović, Lin-Yang Cheng, Simon Messner

Mol Cell Proteomics· May 2015

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Differential basolateral-apical distribution of scavenger receptor, class B, type I in cultured cells and the liver.
Stefanie Fruhwürth, Werner J Kovacs, Robert Bittman, Simon Messner, Clemens Röhrl

Histochem Cell Biol· December 2014

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Hepatic toxicology following single and multiple exposure of engineered nanomaterials utilising a novel primary human 3D liver microtissue model.
Ali Kermanizadeh, Mille Løhr, Martin Roursgaard, Simon Messner, Patrina Gunness

Part Fibre Toxicol· October 2014

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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Patricio Godoy, Nicola J Hewitt, Ute Albrecht, Melvin E Andersen, Nariman Ansari, Simon Messner

Arch Toxicol· August 2013

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Identification of distinct amino acids as ADP-ribose acceptor sites by mass spectrometry.
Florian Rosenthal, Simon Messner, Bernd Roschitzki, Peter Gehrig, Paolo Nanni

Methods Mol Biol· January 2012

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Histone ADP-ribosylation in DNA repair, replication and transcription.
Simon Messner, Michael O Hottiger

Trends Cell Biol· September 2011

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PARP1 ADP-ribosylates lysine residues of the core histone tails.
Simon Messner, Matthias Altmeyer, Hongtao Zhao, Andrea Pozivil, Bernd Roschitzki

Nucleic Acids Res· October 2010

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Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function.
Simon Messner, David Schuermann, Matthias Altmeyer, Ingrid Kassner, Darja Schmidt

FASEB J· November 2009

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Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites.
Matthias Altmeyer, Simon Messner, Paul O Hassa, Monika Fey, Michael O Hottiger

Nucleic Acids Res· June 2009

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Physarum nitric oxide synthases: genomic structures and enzymology of recombinant proteins.
Simon Messner, Stephan Leitner, Christian Bommassar, Georg Golderer, Peter Gröbner

Biochem J· March 2009

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Poly(ADP-ribose) polymerase 1 promotes tumor cell survival by coactivating hypoxia-inducible factor-1-dependent gene expression.
Michael Elser, Lubor Borsig, Paul O Hassa, Suheda Erener, Simon Messner

Mol Cancer Res· February 2008

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