Publications by authors named "Simon Satchell"

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Association between glucosamine use and albuminuria in the UK: a cohort and Mendelian randomisation study.
Samantha Jl Hayward, Andrei Constantinescu, Emma Hazelwood, Matthew J Butler, Emma E Vincent, Simon C Satchell

BMJ Open· November 2025

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The glomerular endothelial glycocalyx as a therapeutic target in proteinuric kidney disease.
Monica Gamez, Raina D Ramnath, Matthew J Butler, Rebecca R Foster, Simon C Satchell

Nat Rev Nephrol· November 2025

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Podocyte-directed VEGFC gene therapy prevents increased glomerular permeability and glycocalyx damage in experimental type 1 diabetes.
Aldara Martin Alonso, Carl J May, Holly Stowell-Connolly, Haijie Wu, Monica Gamez, Simon C Satchell

Mol Ther· October 2025

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Matrix metalloproteinase-9 mediates endothelial glycocalyx degradation and correlates with severity of hemorrhagic fever with renal syndrome.
Chloé Jacquet, Rasmus Gustafsson, Ankit Kumar Patel, Magnus Hansson, Gregory Rankin, Simon Satchell

iScience· September 2025

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Biosynthesis, characterisation and biocompatibility of a unique and elastomeric medium chain-length polyhydroxyalkanoates for kidney glomerular tissue engineering.
Syed Mohammad Daniel Syed Mohamed, Jack Tuffin, Judy Watson, Andrea Mele, Annabelle Fricker, Simon C Satchell

Mater Today Bio· August 2025

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Profiling of insulin-resistant kidney models and human biopsies reveals common and cell-type-specific mechanisms underpinning Diabetic Kidney Disease.
Abigail C Lay, Van Du T Tran, Viji Nair, Virginie Betin, Jennifer A Hurcombe, Simon C Satchell

Nat Commun· November 2024

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Adiponectin Reduces Glomerular Endothelial Glycocalyx Disruption and Restores Glomerular Barrier Function in a Mouse Model of Type 2 Diabetes.
Sarah Fawaz, Aldara Martin Alonso, Yan Qiu, Raina Ramnath, Holly Stowell-Connolly, Simon C Satchell

Diabetes· June 2024

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Author Correction: The adipokine leptin modulates adventitial pericyte functions by autocrine and paracrine signalling.
Federica Riu, Sadie C Slater, Eva Jover Garcia, Iker Rodriguez-Arabaolaza, Valeria Alvino, Simon Satchell

Sci Rep· March 2024

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Heparanase inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes.
Monica Gamez, Hesham E Elhegni, Sarah Fawaz, Kwan Ho Ho, Neill W Campbell, Simon C Satchell

Cardiovasc Diabetol· February 2024

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Shiga toxin targets the podocyte causing hemolytic uremic syndrome through endothelial complement activation.
Emily E Bowen, Jennifer A Hurcombe, Fern Barrington, Lindsay S Keir, Louise K Farmer, Simon C Satchell

Med· November 2023

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The unique structural and functional characteristics of glomerular endothelial cell fenestrations and their potential as a therapeutic target in kidney disease.
Natalie C Finch, Chris R Neal, Gavin I Welsh, Rebecca R Foster, Simon C Satchell

Am J Physiol Renal Physiol· October 2023

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Aldosterone: Essential for Life but Damaging to the Vascular Endothelium.
Michael Crompton, Laura J Skinner, Simon C Satchell, Matthew J Butler

Biomolecules· June 2023

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Mineralocorticoid receptor antagonism in diabetes reduces albuminuria by preserving the glomerular endothelial glycocalyx.
Michael Crompton, Joanne K Ferguson, Raina D Ramnath, Karen L Onions, Anna S Ogier, Simon C Satchell

JCI Insight· March 2023

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Circulating hyaluronan as a marker of endothelial glycocalyx damage in dogs with myxomatous mitral valve disease and dogs in a hypercoagulable state.
Sara J Lawrence-Mills, Melanie J Hezzell, Sophie E Adamantos, Iris Chan, Kieran Borgeat, Simon Satchell

Vet J· July 2022

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Visualising the endothelial glycocalyx in dogs.
Sara J Lawrence-Mills, Chris R Neal, Simon C Satchell, Gavin I Welsh, Rebecca R Foster

Vet J· July 2022

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Reduced Glomerular Filtration in Diabetes Is Attributable to Loss of Density and Increased Resistance of Glomerular Endothelial Cell Fenestrations.
Natalie C Finch, Sarah S Fawaz, Chris R Neal, Matthew J Butler, Vivian K Lee, Simon C Satchell

J Am Soc Nephrol· June 2022

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Endothelial glycocalyx is damaged in diabetic cardiomyopathy: angiopoietin 1 restores glycocalyx and improves diastolic function in mice.
Yan Qiu, Stanley Buffonge, Raina Ramnath, Sophie Jenner, Sarah Fawaz, Simon C Satchell

Diabetologia· May 2022

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Cerebral microvascular endothelial glycocalyx damage, its implications on the blood-brain barrier and a possible contributor to cognitive impairment.
Patrice Stoddart, Simon C Satchell, Raina Ramnath

Brain Res· April 2022

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Minimal Change Disease Is Associated With Endothelial Glycocalyx Degradation and Endothelial Activation.
Colin Bauer, Federica Piani, Mindy Banks, Flor A Ordoñez, Carmen de Lucas-Collantes, Simon C Satchell

Kidney Int Rep· April 2022

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Gain-of-Function Mutations R249C and S250C in Complement C2 Protein Increase C3 Deposition in the Presence of C-Reactive Protein.
Aleksandra Urban, Daria Kowalska, Grzegorz Stasiłojć, Alicja Kuźniewska, Anna Skrobińska, Simon Satchell

Front Immunol· February 2022

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GlomSpheres as a 3D co-culture spheroid model of the kidney glomerulus for rapid drug-screening.
Jack Tuffin, Musleeha Chesor, Valeryia Kuzmuk, Tim Johnson, Simon C Satchell

Commun Biol· December 2021

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CRISPR/Cas9-Engineered HLA-Deleted Glomerular Endothelial Cells as a Tool to Predict Pathogenic Non-HLA Antibodies in Kidney Transplant Recipients.
Baptiste Lamarthée, Carole Burger, Charlotte Leclaire, Emilie Lebraud, Aniela Zablocki, Simon Satchell

J Am Soc Nephrol· December 2021

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Natural antibody and complement activation characterize patients with idiopathic nephrotic syndrome.
Howard Trachtman, Jennifer Laskowski, Cameron Lee, Brandon Renner, Andrew Feemster, Simon Satchell

Am J Physiol Renal Physiol· October 2021

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Effect of endothelial cell heterogeneity on nanoparticle uptake.
Aldy Aliyandi, Simon Satchell, Ronald E Unger, Birke Bartosch, Romain Parent

Int J Pharm· September 2020

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Cystatin C and α-1-Microglobulin Predict Severe Acute Kidney Injury in Patients with Hemorrhagic Fever with Renal Syndrome.
Magnus Hansson, Rasmus Gustafsson, Chloé Jacquet, Nedia Chebaane, Simon Satchell

Pathogens· August 2020

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