Publications by authors named "Simona Distinto"

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Synthesis and Evaluation of Thiazolidinone-Isatin Hybrids for Selective Inhibition of Cancer-Related Carbonic Anhydrases.
Alessia Onali, Erica Sanna, Antonio Lupia, Daniela Secci, Giulia Atzeni, Simona Distinto

ACS Med Chem Lett· April 2025

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Suppression of lipopolysaccharide-induced COX-2 expression via p38MAPK, JNK, and C/EBPβ phosphorylation inhibition by furomagydarin A, a benzofuran glycoside from .
Shiu-Wen Huang, Ming Jen Hsu, Hsiu-Chen Chen, Rita Meleddu, Simona Distinto

J Enzyme Inhib Med Chem· December 2024

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New Structural Features of Isatin Dihydrothiazole Hybrids for Selective Carbonic Anhydrase Inhibitors.
Daniela Secci, Simona Distinto, Alessia Onali, Erica Sanna, Antonio Lupia

ACS Med Chem Lett· November 2024

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Exploring the 1-(4-Nitrophenyl)-3-arylprop-2-en-1-one Scaffold for the Selective Inhibition of Monoamine Oxidase B.
Rita Meleddu, Antonella Fais, Benedetta Era, Sonia Floris, Simona Distinto

ACS Med Chem Lett· October 2024

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Privileged Scaffold Hybridization in the Design of Carbonic Anhydrase Inhibitors.
Daniela Secci, Erica Sanna, Simona Distinto, Alessia Onali, Antonio Lupia

Molecules· September 2024

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2H-chromene and 7H-furo-chromene derivatives selectively inhibit tumour associated human carbonic anhydrase IX and XII isoforms.
Lisa Sequeira, Simona Distinto, Rita Meleddu, Marco Gaspari, Andrea Angeli

J Enzyme Inhib Med Chem· December 2023

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5-Nitro-3-(2-(4-phenylthiazol-2-yl)hydrazineylidene)indolin-2-one derivatives inhibit HIV-1 replication by a multitarget mechanism of action.
Angela Corona, Rita Meleddu, Olivier Delelis, Frederic Subra, Filippo Cottiglia, Simona Distinto

Front Cell Infect Microbiol· July 2023

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Ebola virus disease: In vivo protection provided by the PAMP restricted TLR3 agonist rintatolimod and its mechanism of action.
Angela Corona, David Strayer, Simona Distinto, Gian Luca Daino, Annalaura Paulis

Antiviral Res· April 2023

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Cynarin blocks Ebola virus replication by counteracting VP35 inhibition of interferon-beta production.
Angela Corona, Elisa Fanunza, Cristiano Salata, Melody Jane Morwitzer, Simona Distinto

Antiviral Res· February 2022

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Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives.
Rita Meleddu, Serenella Deplano, Elias Maccioni, Francesco Ortuso, Filippo Cottiglia, Simona Distinto

J Enzyme Inhib Med Chem· December 2021

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Flavonoids and Acid-Hydrolysis derivatives of -Clerodane diterpenes from subsp. as inhibitors of the HIV-1 reverse transcriptase-associated RNase H function.
Benedetta Fois, Angela Corona, Enzo Tramontano, Simona Distinto, Elias Maccioni

J Enzyme Inhib Med Chem· December 2021

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Exploring New Scaffolds for the Dual Inhibition of HIV-1 RT Polymerase and Ribonuclease Associated Functions.
Rita Meleddu, Angela Corona, Simona Distinto, Filippo Cottiglia, Serenella Deplano

Molecules· June 2021

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2-(2-Methyl-2-nitrovinyl)furan but Not Furvina Interfere with Agr Quorum-Sensing System and Potentiate the Action of Fusidic Acid against Biofilms.
Diana Oliveira, Anabela Borges, Reinaldo Molina Ruiz, Zenaida Rodríguez Negrín, Simona Distinto

Int J Mol Sci· January 2021

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Coumarins from as inhibitors of the tumour-associated carbonic anhydrases IX and XII: isolation, biological studies and in silico evaluation.
Benedetta Fois, Simona Distinto, Rita Meleddu, Serenella Deplano, Elias Maccioni

J Enzyme Inhib Med Chem· December 2020

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Targeting HIV-1 RNase H: -(2-Hydroxy-benzylidene)-3,4,5-Trihydroxybenzoylhydrazone as Selective Inhibitor Active against NNRTIs-Resistant Variants.
Angela Corona, Ester Ballana, Simona Distinto, Dominga Rogolino, Claudia Del Vecchio

Viruses· July 2020

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Quercetin Blocks Ebola Virus Infection by Counteracting the VP24 Interferon-Inhibitory Function.
Elisa Fanunza, Mathieu Iampietro, Simona Distinto, Angela Corona, Marina Quartu

Antimicrob Agents Chemother· June 2020

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New Dihydrothiazole Benzensulfonamides: Looking for Selectivity toward Carbonic Anhydrase Isoforms I, II, IX, and XII.
Rita Meleddu, Simona Distinto, Filippo Cottiglia, Rossella Angius, Pierluigi Caboni

ACS Med Chem Lett· May 2020

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From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors.
Serena Massari, Angela Corona, Simona Distinto, Jenny Desantis, Alessia Caredda

J Enzyme Inhib Med Chem· December 2019

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Exploring new structural features of the 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzenesulphonamide scaffold for the inhibition of human carbonic anhydrases.
Simona Distinto, Rita Meleddu, Francesco Ortuso, Filippo Cottiglia, Serenella Deplano

J Enzyme Inhib Med Chem· December 2019

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Ferulic Acid Esters and Withanolides: In Search of Withania somnifera GABA Receptor Modulators.
Vijay P Sonar, Benedetta Fois, Simona Distinto, Elias Maccioni, Rita Meleddu

J Nat Prod· May 2019

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Investigating the Anticancer Activity of Isatin/Dihydropyrazole Hybrids.
Rita Meleddu, Vilma Petrikaite, Simona Distinto, Antonella Arridu, Rossella Angius

ACS Med Chem Lett· April 2019

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Novel natural non-nucleoside inhibitors of HIV-1 reverse transcriptase identified by shape- and structure-based virtual screening techniques.
Giosuè Costa, Roberta Rocca, Angela Corona, Nicole Grandi, Federica Moraca, Simona Distinto

Eur J Med Chem· January 2019

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Identification of Myricetin as an Ebola Virus VP35-Double-Stranded RNA Interaction Inhibitor through a Novel Fluorescence-Based Assay.
Gian Luca Daino, Aldo Frau, Cinzia Sanna, Daniela Rigano, Simona Distinto

Biochemistry· November 2018

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Tuning the Dual Inhibition of Carbonic Anhydrase and Cyclooxygenase by Dihydrothiazole Benzensulfonamides.
Rita Meleddu, Simona Distinto, Filippo Cottiglia, Rossella Angius, Marco Gaspari

ACS Med Chem Lett· October 2018

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Targeting Tumor Associated Carbonic Anhydrases IX and XII: Highly Isozyme Selective Coumarin and Psoralen Inhibitors.
Claudia Melis, Simona Distinto, Giulia Bianco, Rita Meleddu, Filippo Cottiglia

ACS Med Chem Lett· July 2018

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