Publications by authors named "Simone Braggio"

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1,2,4-Triazolyl 5-Azaspiro[2.4]heptanes: Lead Identification and Early Lead Optimization of a New Series of Potent and Selective Dopamine D3 Receptor Antagonists.
Fabrizio Micheli, Alessia Bacchi, Simone Braggio, Laura Castelletti, Palmina Cavallini

J Med Chem· September 2016

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1,2,4-Triazolyl octahydropyrrolo[2,3-b]pyrroles: A new series of potent and selective dopamine D3 receptor antagonists.
Fabrizio Micheli, Andrea Bernardelli, Federica Bianchi, Simone Braggio, Laura Castelletti

Bioorg Med Chem· April 2016

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Novel morpholine scaffolds as selective dopamine (DA) D3 receptor antagonists.
Fabrizio Micheli, Susanna Cremonesi, Teresa Semeraro, Luca Tarsi, Silvia Tomelleri, Simone Braggio

Bioorg Med Chem Lett· February 2016

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Identification, biological characterization and pharmacophoric analysis of a new potent and selective NK1 receptor antagonist clinical candidate.
Romano Di Fabio, Giuseppe Alvaro, Simone Braggio, Renzo Carletti, Philip A Gerrard

Bioorg Med Chem· November 2013

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Quality by design in lead optimization: a new strategy to address productivity in drug discovery.
Tino Rossi, Simone Braggio

Curr Opin Pharmacol· October 2011

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Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2 receptor antagonist useful for treatment of sleep disorders.
Romano Di Fabio, Annalisa Pellacani, Stefania Faedo, Adelheid Roth, Laura Piccoli, Simone Braggio

Bioorg Med Chem Lett· September 2011

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Application of drug efficiency index in drug discovery: a strategy towards low therapeutic dose.
Dino Montanari, Elisabetta Chiarparin, Matthew Paul Gleeson, Simone Braggio, Raffaele Longhi

Expert Opin Drug Discov· September 2011

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Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method.
Raffaele Longhi, Silvia Corbioli, Stefano Fontana, Federicia Vinco, Simone Braggio

Drug Metab Dispos· February 2011

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Exploration of the amine terminus in a novel series of 1,2,4-triazolo-3-yl-azabicyclo[3.1.0]hexanes as selective dopamine D3 receptor antagonists.
Fabrizio Micheli, Luca Arista, Barbara Bertani, Simone Braggio, Anna Maria Capelli

J Med Chem· October 2010

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A specific and direct comparison of the trifluoromethyl and pentafluoro sulfanyl groups on the selective dopamine D(3) antagonist 3-(3-{[4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazol-3-yl]thio}propyl)-1-phenyl-3-azabicyclo[3.1.0]hexane template.
Fabrizio Micheli, Daniele Andreotti, Simone Braggio, Anna Checchia

Bioorg Med Chem Lett· August 2010

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6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor.
Fabrizio Micheli, Paolo Cavanni, Daniele Andreotti, Roberto Arban, Roberto Benedetti, Simone Braggio

J Med Chem· July 2010

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Drug efficiency: a new concept to guide lead optimization programs towards the selection of better clinical candidates.
Simone Braggio, Dino Montanari, Tino Rossi, Emiliangelo Ratti

Expert Opin Drug Discov· July 2010

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Triazolyl azabicyclo[3.1.0]hexanes: A class of potent and selective dopamine D(3) receptor antagonists.
Giorgio Bonanomi, Simone Braggio, Anna Maria Capelli, Anna Checchia, Romano Di Fabio

ChemMedChem· May 2010

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A
Assessing brain free fraction in early drug discovery.
Kevin D Read, Simone Braggio

Expert Opin Drug Metab Toxicol· March 2010

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1-(Aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes and 6-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes: a new series of potent and selective triple reuptake inhibitors.
Fabrizio Micheli, Paolo Cavanni, Roberto Arban, Roberto Benedetti, Barbara Bertani, Simone Braggio

J Med Chem· March 2010

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1,2,4-Triazolyl azabicyclo[3.1.0]hexanes: a new series of potent and selective dopamine D(3) receptor antagonists.
Fabrizio Micheli, Luca Arista, Giorgio Bonanomi, Frank E Blaney, Simone Braggio

J Med Chem· January 2010

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Development and validation of a high-throughput method for the quantitative analysis of D-amphetamine in rat blood using liquid chromatography/MS3 on a hybrid triple quadrupole-linear ion trap mass spectrometer and its application to a pharmacokinetic study.
Nicola Cesari, Stefano Fontana, Dino Montanari, Simone Braggio

J Chromatogr B Analyt Technol Biomed Life Sci· January 2010

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Dopamine D(3) receptor antagonists: The quest for a potentially selective PET ligand. Part two: Lead optimization.
Fabrizio Micheli, Ian Holmes, Luca Arista, Giorgio Bonanomi, Simone Braggio

Bioorg Med Chem Lett· August 2009

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Synthesis and pharmacological characterization of novel druglike corticotropin-releasing factor 1 antagonists.
Romano Di Fabio, Yves St-Denis, Fabio M Sabbatini, Daniele Andreotti, Roberto Arban, Simone Braggio

J Med Chem· December 2008

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Dihydropyrrole[2,3-d]pyridine derivatives as novel corticotropin-releasing factor-1 antagonists: mapping of the receptor binding pocket by in silico docking studies.
Romano Di Fabio, Roberto Arban, Giovanni Bernasconi, Simone Braggio, Frank E Blaney

J Med Chem· November 2008

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New fused benzazepine as selective D3 receptor antagonists. Synthesis and biological evaluation. Part 2: [g]-fused and hetero-fused systems.
Fabrizio Micheli, Giorgio Bonanomi, Simone Braggio, Anna Maria Capelli, Federica Damiani

Bioorg Med Chem Lett· February 2008

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New fused benzazepine as selective D3 receptor antagonists. Synthesis and biological evaluation. Part one: [h]-fused tricyclic systems.
Fabrizio Micheli, Giorgio Bonanomi, Simone Braggio, Anna Maria Capelli, Paolo Celestini

Bioorg Med Chem Lett· February 2008

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1,2,4-triazol-3-yl-thiopropyl-tetrahydrobenzazepines: a series of potent and selective dopamine D(3) receptor antagonists.
Fabrizio Micheli, Giorgio Bonanomi, Frank E Blaney, Simone Braggio, Anna Maria Capelli

J Med Chem· October 2007

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Novel carbazole derivatives as NPY Y1 antagonists.
Colin P Leslie, Romano Di Fabio, Francesca Bonetti, Manuela Borriello, Simone Braggio

Bioorg Med Chem Lett· February 2007

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In vitro and in vivo pharmacokinetics-pharmacodynamics of GV143253A, a novel trinem.
Livia Ferrari, Laura Iavarone, Simone Braggio, Enza Di Modugno

Antimicrob Agents Chemother· February 2003

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