Publications by authors named "Simone Kennard"

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Adipocyte Leptin Signaling Regulates Glycemia and Cardiovascular Function by Enhancing Brown Adipose Tissue Thermogenesis in Obese Male Mice.
Yoichi Ono, Simone Kennard, Benjamin T Wall, Jing Ma, Eric J Belin de Chantemèle

Diabetes· January 2026

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Female sex hormones do not drive the sex-specific mechanisms of obesity-related hypertension.
Candee T Barris, Taylor C Kress, Galina Antonova, Coleton R Jordan, Austin Newman, Simone Kennard

Am J Physiol Heart Circ Physiol· December 2025

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Adipocyte Leptin Signaling Regulates Glycemia and Cardiovascular Function via Enhancing Brown Adipose Tissue Thermogenesis in Obese Male Mice.
Yoichi Ono, Simone Kennard, Benjamin T Wall, Jing Ma, Eric J Belin de Chantemèle

bioRxiv· October 2025

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Novel Experimental Approach to Investigate Immune Control of Vascular Function: Co-culture of Murine Aortas With T Lymphocytes or Macrophages.
Taylor C Kress, Candee T Barris, Simone Kennard, Eric J Belin de Chantemèle

Bio Protoc· September 2025

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Loss of neurofibromin induces inflammatory macrophage phenotypic switch and retinal neovascularization via GLUT1 activation.
Yusra Zaidi, Rebekah Tritz, Nida Zaidi, Faisal Nabi, Syed Adeel H Zaidi, Simone Kennard

Cell Rep· May 2025

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CD4 T Cells Expressing Viral Proteins Induce HIV-Associated Endothelial Dysfunction and Hypertension Through Interleukin 1α-Mediated Increases in Endothelial NADPH Oxidase 1.
Taylor C Kress, Candee T Barris, Laszlo Kovacs, Beryl N Khakina, Coleton R Jordan, Simone Kennard

Circulation· April 2025

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12-week Dolutegravir treatment marginally reduces energy expenditure but does not increase body weight or alter vascular function in a murine model of Human Immunodeficiency Virus infection.
Taylor C Kress, Priscilla Ajala, Coleton R Jordan, James Mintz, Rodger MacArthur, Simone Kennard

Vascul Pharmacol· June 2024

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Type 1 Diabetes Impairs Endothelium-Dependent Relaxation Via Increasing Endothelial Cell Glycolysis Through Advanced Glycation End Products, PFKFB3, and Nox1-Mediated Mechanisms.
Reem T Atawia, Robert K Batori, Coleton R Jordan, Simone Kennard, Galina Antonova

Hypertension· October 2023

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Endothelial leptin receptor is dispensable for leptin-induced sympatho-activation and hypertension in male mice.
Reem T Atawia, Jessica L Faulkner, Vinay Mehta, Andrew Austin, Coleton R Jordan, Simone Kennard

Vascul Pharmacol· October 2022

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Midgestation Leptin Infusion Induces Characteristics of Clinical Preeclampsia in Mice, Which Is Ablated by Endothelial Mineralocorticoid Receptor Deletion.
Jessica L Faulkner, Derrian Wright, Galina Antonova, Iris Z Jaffe, Simone Kennard

Hypertension· July 2022

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Chronic Exposure to HIV-Derived Protein Tat Impairs Endothelial Function via Indirect Alteration in Fat Mass and Nox1-Mediated Mechanisms in Mice.
Laszlo Kovacs, Thiago Bruder-Nascimento, Lindsey Greene, Simone Kennard, Eric J Belin de Chantemèle

Int J Mol Sci· October 2021

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Reduced Endothelial Leptin Signaling Increases Vascular Adrenergic Reactivity in a Mouse Model of Congenital Generalized Lipodystrophy.
Thiago Bruder-Nascimento, Taylor C Kress, Matthew Pearson, Weiqin Chen, Simone Kennard

Int J Mol Sci· September 2021

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Nf1 heterozygous mice recapitulate the anthropometric and metabolic features of human neurofibromatosis type 1.
Rebekah Tritz, Tyler Benson, Valerie Harris, Farlyn Z Hudson, James Mintz, Simone Kennard

Transl Res· February 2021

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Dietary sodium restriction sex specifically impairs endothelial function via mineralocorticoid receptor-dependent reduction in NO bioavailability in Balb/C mice.
Jessica L Faulkner, Daisy Harwood, Simone Kennard, Galina Antonova, Nicolas Clere

Am J Physiol Heart Circ Physiol· January 2021

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Selective deletion of endothelial mineralocorticoid receptor protects from vascular dysfunction in sodium-restricted female mice.
Jessica L Faulkner, Emily Lluch, Simone Kennard, Galina Antonova, Iris Z Jaffe

Biol Sex Differ· November 2020

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HIV Protease Inhibitor Ritonavir Impairs Endothelial Function Via Reduction in Adipose Mass and Endothelial Leptin Receptor-Dependent Increases in NADPH Oxidase 1 (Nox1), C-C Chemokine Receptor Type 5 (CCR5), and Inflammation.
Thiago Bruder-Nascimento, Taylor C Kress, Simone Kennard, Eric J Belin de Chantemèle

J Am Heart Assoc· October 2020

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Selective deficiency in endothelial PTP1B protects from diabetes and endoplasmic reticulum stress-associated endothelial dysfunction via preventing endothelial cell apoptosis.
Samuel Legeay, Pierre Fautrat, J Blake Norman, Galina Antonova, Simone Kennard

Biomed Pharmacother· July 2020

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Leptin Restores Endothelial Function via Endothelial PPARγ-Nox1-Mediated Mechanisms in a Mouse Model of Congenital Generalized Lipodystrophy.
Thiago Bruder-Nascimento, Jessica L Faulkner, Stephen Haigh, Simone Kennard, Galina Antonova

Hypertension· December 2019

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Progesterone Predisposes Females to Obesity-Associated Leptin-Mediated Endothelial Dysfunction via Upregulating Endothelial MR (Mineralocorticoid Receptor) Expression.
Jessica L Faulkner, Simone Kennard, Anne-Cecile Huby, Galina Antonova, Qing Lu

Hypertension· September 2019

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Lack of Suppression of Aldosterone Production Leads to Salt-Sensitive Hypertension in Female but Not Male Balb/C Mice.
Jessica L Faulkner, Daisy Harwood, Lily Bender, Lenee Shrestha, Michael W Brands, Simone Kennard

Hypertension· December 2018

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Ptp1b deletion in pro-opiomelanocortin neurons increases energy expenditure and impairs endothelial function via TNF-α dependent mechanisms.
Thiago Bruder-Nascimento, Simone Kennard, Galina Antonova, James D Mintz, Kendra K Bence

Clin Sci (Lond)· June 2016

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TNFα reduces eNOS activity in endothelial cells through serine 116 phosphorylation and Pin1 binding: Confirmation of a direct, inhibitory interaction of Pin1 with eNOS.
Simone Kennard, Ling Ruan, Ryan J Buffett, David Fulton, Richard C Venema

Vascul Pharmacol· June 2016

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Calcineurin-mediated dephosphorylation of eNOS at serine 116 affects eNOS enzymatic activity indirectly by facilitating c-Src binding and tyrosine 83 phosphorylation.
Ling Ruan, Christina M Torres, Ryan J Buffett, Simone Kennard, David Fulton

Vascul Pharmacol· March 2014

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Notch2 and Notch3 function together to regulate vascular smooth muscle development.
Qingqing Wang, Ning Zhao, Simone Kennard, Brenda Lilly

PLoS One· September 2012

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Endothelial cells downregulate apolipoprotein D expression in mural cells through paracrine secretion and Notch signaling.
Mohanasundari Pajaniappan, Nancy K Glober, Simone Kennard, Hua Liu, Ning Zhao

Am J Physiol Heart Circ Physiol· September 2011

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