Publications by authors named "Simone M Crivelli"

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Abnormal Regulation of Mitochondrial Sphingolipids during Aging and Alzheimer's Disease.
Simone M Crivelli, Zainuddin Quadri, Ahmed Elsherbini, Hemendra J Vekaria, Patrick G Sullivan

ASN Neuro· November 2024

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The effects of APOE4 and familial Alzheimer's disease mutations on free fatty acid profiles in mouse brain are age- and sex-dependent.
Sandra den Hoedt, Simone M Crivelli, Kristien Y Dorst-Lagerwerf, Frank P J Leijten, Mario Losen

J Neurochem· September 2024

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Exploring the role of mitochondrial uncoupling protein 4 in brain metabolism: implications for Alzheimer's disease.
Simone M Crivelli, Aisylu Gaifullina, Jean-Yves Chatton

Front Neurosci· September 2024

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The Effect of FTY720 on Sphingolipid Imbalance and Cognitive Decline in Aged EFAD Mice.
Qian Luo, Simone M Crivelli, Shenghua Zong, Caterina Giovagnoni, Daan van Kruining

J Alzheimers Dis Rep· September 2024

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Palmitoylation of acetylated tubulin and association with ceramide-rich platforms is critical for ciliogenesis.
Priyanka Tripathi, Zhihui Zhu, Haiyan Qin, Ahmed Elsherbini, Simone M Crivelli

J Lipid Res· July 2024

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Ceramide-mediated orchestration of oxidative stress response through filopodia-derived small extracellular vesicles.
Zainuddin Quadri, Ahmed Elsherbini, Simone M Crivelli, Salim S El-Amouri, Priyanka Tripathi

J Extracell Vesicles· July 2024

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Plasma ceramides relate to mild cognitive impairment in middle-aged men: The Maastricht Study.
Daan van Kruining, Mario Losen, Simone M Crivelli, Joost J A de Jong, Jacobus F A Jansen

Alzheimers Dement (Amst)· September 2023

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The S1P receptor 1 antagonist Ponesimod reduces TLR4-induced neuroinflammation and increases Aβ clearance in 5XFAD mice.
Zhihui Zhu, Liping Zhang, Ahmed Elsherbini, Simone M Crivelli, Priyanka Tripathi

EBioMedicine· August 2023

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Inhibition of acid sphingomyelinase reduces reactive astrocyte secretion of mitotoxic extracellular vesicles and improves Alzheimer's disease pathology in the 5xFAD mouse.
Simone M Crivelli, Zainuddin Quadri, Hemendra J Vekaria, Zhihui Zhu, Priyanka Tripathi

Acta Neuropathol Commun· August 2023

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Novel Isolation Method Reveals Sex-Specific Composition and Neurotoxicity of Small Extracellular Vesicles in a Mouse Model of Alzheimer's Disease.
Ahmed Elsherbini, Zhihui Zhu, Zainuddin Quadri, Simone M Crivelli, Xiaojia Ren

Cells· June 2023

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FTY720 decreases ceramides levels in the brain and prevents memory impairments in a mouse model of familial Alzheimer's disease expressing APOE4.
Simone M Crivelli, Qian Luo, Daan van Kruining, Caterina Giovagnoni, Marina Mané-Damas

Biomed Pharmacother· August 2022

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Function of ceramide transfer protein for biogenesis and sphingolipid composition of extracellular vesicles.
Simone M Crivelli, Caterina Giovagnoni, Zhihui Zhu, Priyanka Tripathi, Ahmed Elsherbini

J Extracell Vesicles· June 2022

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Neutral Sphingomyelinase 2 Mediates Oxidative Stress Effects on Astrocyte Senescence and Synaptic Plasticity Transcripts.
Zhihui Zhu, Zainuddin Quadri, Simone M Crivelli, Ahmed Elsherbini, Liping Zhang

Mol Neurobiol· May 2022

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Effects of Sex, Age, and Apolipoprotein E Genotype on Brain Ceramides and Sphingosine-1-Phosphate in Alzheimer's Disease and Control Mice.
Sandra den Hoedt, Simone M Crivelli, Frank P J Leijten, Mario Losen, Jo A A Stevens

Front Aging Neurosci· October 2021

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Sphingolipids in Alzheimer's disease, how can we target them?
Simone M Crivelli, Caterina Giovagnoni, Lars Visseren, Anna-Lena Scheithauer, Nienke de Wit

Adv Drug Deliv Rev· August 2021

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Extracellular Vesicles Containing Ceramide-Rich Platforms: "Mobile Raft" Isolation and Analysis.
Ahmed Elsherbini, Haiyan Qin, Zhihui Zhu, Priyanka Tripathi, Guanghu Wang, Simone M Crivelli

Methods Mol Biol· March 2021

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Immunofluorescence Labeling of Lipid-Binding Proteins CERTs to Monitor Lipid Raft Dynamics.
Caterina Giovagnoni, Simone M Crivelli, Mario Losen, Pilar Martinez-Martinez

Methods Mol Biol· March 2021

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Cross-Link/Proximity Ligation Assay for Visualization of Lipid and Protein Complexes in Lipid Rafts.
Priyanka Tripathi, Zhihui Zhu, Haiyan Qin, Ahmed Elsherbini, Emily A Roush, Simone M Crivelli

Methods Mol Biol· February 2021

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CERT reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer's disease.
Simone M Crivelli, Qian Luo, Jo A A Stevens, Caterina Giovagnoni, Daan van Kruining

Alzheimers Res Ther· February 2021

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Ceramide analog [F]F-HPA-12 detects sphingolipid disbalance in the brain of Alzheimer's disease transgenic mice by functioning as a metabolic probe.
Simone M Crivelli, Daan van Kruining, Qian Luo, Jo A A Stevens, Caterina Giovagnoni

Sci Rep· November 2020

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In vivo evidence of exosome-mediated Aβ neurotoxicity.
Ahmed Elsherbini, Haiyan Qin, Zhihui Zhu, Priyanka Tripathi, Simone M Crivelli

Acta Neuropathol Commun· July 2020

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Association of Aβ with ceramide-enriched astrosomes mediates Aβ neurotoxicity.
Ahmed Elsherbini, Alexander S Kirov, Michael B Dinkins, Guanghu Wang, Haiyan Qin, Simone M Crivelli

Acta Neuropathol Commun· April 2020

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Visualization of Ceramide-Associated Proteins in Ceramide-Rich Platforms Using a Cross-Linkable Ceramide Analog and Proximity Ligation Assays With Anti-ceramide Antibody.
Xue Jiang, Zhihui Zhu, Haiyan Qin, Priyanka Tripathi, Liansheng Zhong, Simone M Crivelli

Front Cell Dev Biol· August 2019

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Pleiotropic Effect of Human ApoE4 on Cerebral Ceramide and Saturated Fatty Acid Levels.
Sandra den Hoedt, Carola I F Janssen, Giuseppe Astarita, Daniele Piomelli, Frank P J Leijten, Simone M Crivelli

J Alzheimers Dis· May 2018

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Synthesis, Radiosynthesis, and Preliminary in vitro and in vivo Evaluation of the Fluorinated Ceramide Trafficking Inhibitor (HPA-12) for Brain Applications.
Simone M Crivelli, Andreas Paulus, Jozef Markus, Matthias Bauwens, Dusan Berkes

J Alzheimers Dis· May 2018

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