Publications by authors named "Simone Perazzolo"

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Classification system proposed to guide the design, development, regulatory approval, and scaling of long acting, small- and macro-molecule parenteral products (CS-BLAP).
Simone Perazzolo, Danny D Shen, Rodney Jy Ho

J Pharm Sci· November 2025

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Long-acting Injectable Containing Lopinavir Eliminates Reliance on Ritonavir Pharmacokinetic Enhancement.
Simone Perazzolo, Charles W Flexner, Zachary R Stephen, Edward P Acosta, Rachel A Bender Ignacio

J Infect Dis· September 2025

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Automated Oral Minimal Models for Rapid Estimation of Insulin Sensitivity and Beta-Cell Responsivity in Large-Scale Data Sets: A Validation Study.
Simone Perazzolo, Alfonso Galderisi, Alice Carr, Colin Dayan, Claudio Cobelli

J Diabetes Sci Technol· September 2025

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The Promises and Prospects of Long-Acting Therapeutics for Treatment and Prevention of Infectious Diseases.
Adeniyi Olagunju, Simone Perazzolo, Zachary R Stephen, Mark Ryan, Xiaolin Xu

Annu Rev Pharmacol Toxicol· September 2025

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Elevations in plasma glucagon are associated with reduced insulin clearance after ingestion of a mixed-macronutrient meal in people with and without type 2 diabetes.
Kieran Smith, Guy S Taylor, Wouter Peeters, Mark Walker, Simone Perazzolo

Diabetologia· November 2024

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SAAM II: A general mathematical modeling rapid prototyping environment.
Simone Perazzolo

CPT Pharmacometrics Syst Pharmacol· July 2024

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Physiologically based Pharmacokinetic Model Validated to Enable Predictions Of Multiple Drugs in a Long-acting Drug-combination Nano-Particles (DcNP): Confirmation with 3 HIV Drugs, Lopinavir, Ritonavir, and Tenofovir in DcNP Products.
Simone Perazzolo, Danny D Shen, Ariel M Scott, Rodney J Y Ho

J Pharm Sci· June 2024

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A novel formulation enabled transformation of 3-HIV drugs tenofovir-lamivudine-dolutegravir from short-acting to long-acting all-in-one injectable.
Simone Perazzolo, Zachary R Stephen, Masa Eguchi, Xiaolin Xu, Rachele Delle Fratte

AIDS· November 2023

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Viral dissemination and immune activation modulate antiretroviral drug levels in lymph nodes of SIV-infected rhesus macaques.
Sharat Srinivasula, Paula Degrange, Simone Perazzolo, Andrew Bonvillain, Amanda Tobery

Front Immunol· October 2023

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Physiologically Based Pharmacokinetic Modeling of 3 HIV Drugs in Combination and the Role of Lymphatic System after Subcutaneous Dosing. Part 2: Model for the Drug-combination Nanoparticles.
Simone Perazzolo, Danny D Shen, Rodney J Y Ho

J Pharm Sci· March 2022

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Physiologically Based Pharmacokinetic Modeling of 3 HIV Drugs in Combination and the Role of Lymphatic System after Subcutaneous Dosing. Part 1: Model for the Free-Drug Mixture.
Simone Perazzolo, Laura M Shireman, Danny D Shen, Rodney J Y Ho

J Pharm Sci· February 2022

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Placental mobilization of free fatty acids contributes to altered materno-fetal transfer in obesity.
Birgit Hirschmugl, Simone Perazzolo, Bram G Sengers, Rohan M Lewis, Michael Gruber

Int J Obes (Lond)· May 2021

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Systems and Clinical Pharmacology of COVID-19 Therapeutic Candidates: A Clinical and Translational Medicine Perspective.
Simone Perazzolo, Linxi Zhu, Weixian Lin, Alexander Nguyen, Rodney J Y Ho

J Pharm Sci· March 2021

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Bictegravir Plus Tenofovir Alafenamide Nanoformulation as a Long-Acting Pre-Exposure Prophylaxis Regimen: Application of Modeling to Design Non-Human Primate Pharmacokinetic Experiments.
Simone Perazzolo, Subhra Mandal, Pavan K Prathipati, Christopher J Destache

Front Pharmacol· December 2020

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Novel Long-Acting Drug Combination Nanoparticles Composed of Gemcitabine and Paclitaxel Enhance Localization of Both Drugs in Metastatic Breast Cancer Nodules.
Jesse Yu, Qingxin Mu, Simone Perazzolo, James I Griffin, Linxi Zhu

Pharm Res· September 2020

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Integration of Computational and Experimental Approaches to Elucidate Mechanisms of First-Pass Lymphatic Drug Sequestration and Long-Acting Pharmacokinetics of the Injectable Triple-HIV Drug Combination TLC-ART 101.
Simone Perazzolo, Laura M Shireman, Lisa A McConnachie, Josefin Koehn, Loren Kinman

J Pharm Sci· May 2020

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In vivo kinetic study of materno-fetal fatty acid transfer in obese and normal weight pregnant women.
Antonio Gázquez, María T Prieto-Sánchez, José E Blanco-Carnero, Dewi van Harskamp, Simone Perazzolo

J Physiol· October 2019

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Three HIV Drugs, Atazanavir, Ritonavir, and Tenofovir, Coformulated in Drug-Combination Nanoparticles Exhibit Long-Acting and Lymphocyte-Targeting Properties in Nonhuman Primates.
Simone Perazzolo, Laura M Shireman, Josefin Koehn, Lisa A McConnachie, John C Kraft

J Pharm Sci· December 2018

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The influence of placental metabolism on fatty acid transfer to the fetus.
Simone Perazzolo, Birgit Hirschmugl, Christian Wadsack, Gernot Desoye, Rohan M Lewis

J Lipid Res· February 2017

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