Publications by authors named "Sin-Fun Sia"

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Reduced Pathogenicity and Transmission Potential of Omicron BA.1 and BA.2 Sublineages Compared with the Early Severe Acute Respiratory Syndrome Coronavirus 2 D614G Variant in Syrian Hamsters.
Wen Su, Ka Tim Choy, Haogao Gu, Sin Fun Sia, Ka Man Cheng

J Infect Dis· May 2023

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Cellular tropism of SARS-CoV-2 in the respiratory tract of Syrian hamsters and B6.Cg-Tg(K18-ACE2)2Prlmn/J transgenic mice.
Hui-Ling Yen, Sophie Valkenburg, Sin Fun Sia, Ka Tim Choy, J S Malik Peiris

Vet Pathol· July 2022

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A(H1N1)pdm09 Influenza Viruses Replicating in Ferret Upper or Lower Respiratory Tract Differed in Onward Transmission Potential by Air.
Chenyi Xie, Wen Su, Sin Fun Sia, Ka-Tim Choy, Steven Morrell

J Infect Dis· January 2022

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Limited onward transmission potential of reassortment genotypes from chickens co-infected with H9N2 and H7N9 avian influenza viruses.
Wen Su, Sin Fun Sia, Ka-Tim Choy, Yue Ji, Dongdong Chen

Emerg Microbes Infect· December 2021

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Neutralizing Monoclonal Antibodies That Target the Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection against SARS-CoV-2 Infection in Syrian Hamsters.
Wen Su, Sin Fun Sia, Aaron J Schmitz, Traci L Bricker, Tyler N Starr

mBio· October 2021

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Pathogenesis and transmission of SARS-CoV-2 in golden hamsters.
Sin Fun Sia, Li-Meng Yan, Alex W H Chin, Kevin Fung, Ka-Tim Choy

Nature· July 2020

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Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro.
Ka-Tim Choy, Alvina Yin-Lam Wong, Prathanporn Kaewpreedee, Sin Fun Sia, Dongdong Chen

Antiviral Res· June 2020

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Defining the sizes of airborne particles that mediate influenza transmission in ferrets.
Jie Zhou, Jianjian Wei, Ka-Tim Choy, Sin Fun Sia, Dewi K Rowlands

Proc Natl Acad Sci U S A· March 2018

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Avian influenza virus directly infects human natural killer cells and inhibits cell activity.
Huawei Mao, Yinping Liu, Sin Fun Sia, J S Malik Peiris, Yu-Lung Lau

Virol Sin· April 2017

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CLEC5A-Mediated Enhancement of the Inflammatory Response in Myeloid Cells Contributes to Influenza Virus Pathogenicity In Vivo.
Ooiean Teng, Szu-Ting Chen, Tsui-Ling Hsu, Sin Fun Sia, Suzanne Cole

J Virol· January 2017

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Transmission of H7N9 Influenza Viruses with a Polymorphism at PB2 Residue 627 in Chickens and Ferrets.
Geraldine S M Luk, Connie Y H Leung, Sin Fun Sia, Ka-Tim Choy, Jie Zhou

J Virol· October 2015

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The R292K mutation that confers resistance to neuraminidase inhibitors leads to competitive fitness loss of A/Shanghai/1/2013 (H7N9) influenza virus in ferrets.
Hui-Ling Yen, Jie Zhou, Ka-Tim Choy, Sin Fun Sia, Ooiean Teng

J Infect Dis· December 2014

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Highly pathogenic avian influenza A H5N1 and pandemic H1N1 virus infections have different phenotypes in Toll-like receptor 3 knockout mice.
Y H Connie Leung, John M Nicholls, Chuk Kwan Ho, Sin Fun Sia, Chris K P Mok

J Gen Virol· September 2014

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Generation and characterization of influenza A viruses with altered polymerase fidelity.
Peter P H Cheung, Simon J Watson, Ka-Tim Choy, Sin Fun Sia, Diana D Y Wong

Nat Commun· September 2014

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Amino acid substitutions in polymerase basic protein 2 gene contribute to the pathogenicity of the novel A/H7N9 influenza virus in mammalian hosts.
Chris Ka Pun Mok, Horace Hok Yeung Lee, Maxime Lestra, John Malcolm Nicholls, Michael Chi Wai Chan, Sin Fun Sia

J Virol· March 2014

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Experimental challenge of chicken vaccinated with commercially available H5 vaccines reveals loss of protection to some highly pathogenic avian influenza H5N1 strains circulating in Hong Kong/China.
Y H Connie Leung, Geraldine Luk, Sin-Fun Sia, Yu-On Wu, Chuk-Kwan Ho

Vaccine· August 2013

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Pathogenicity of the novel A/H7N9 influenza virus in mice.
Chris Ka Pun Mok, Horace Hok Yeung Lee, Michael Chi Wai Chan, Sin Fun Sia, Maxime Lestra

mBio· July 2013

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Evaluation of a Subunit H5 Vaccine and an Inactivated H5N2 Avian Influenza Marker Vaccine in Ducks Challenged with Vietnamese H5N1 Highly Pathogenic Avian Influenza Virus.
Tze-Hoong Chua, Connie Y H Leung, H E Fang, Chun-Kin Chow, Siu-Kit Ma, Sin-Fun Sia, Siang Thai Chew

Influenza Res Treat· October 2012

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Comparable fitness and transmissibility between oseltamivir-resistant pandemic 2009 and seasonal H1N1 influenza viruses with the H275Y neuraminidase mutation.
Diana D Y Wong, Ka-Tim Choy, Renee W Y Chan, Sin Fun Sia, Hsin-Ping Chiu

J Virol· October 2012

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Amino acid residues 253 and 591 of the PB2 protein of avian influenza virus A H9N2 contribute to mammalian pathogenesis.
Chris Ka Pun Mok, Hui Ling Yen, May Yan Mei Yu, Kit Man Yuen, Sin Fun Sia

J Virol· September 2011

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The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a gammadelta T cell population in humanized mice.
Wenwei Tu, Jian Zheng, Yinping Liu, Sin Fun Sia, Ming Liu

J Exp Med· July 2011

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Influenza virus directly infects human natural killer cells and induces cell apoptosis.
Huawei Mao, Wenwei Tu, Gang Qin, Helen Ka Wai Law, Sin Fun Sia

J Virol· September 2009

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Identifying the species-origin of faecal droppings used for avian influenza virus surveillance in wild-birds.
Peter P Cheung, Y H Connie Leung, Chun-Kin Chow, Chi-Fung Ng, Chun-Lok Tsang, Sin-Fun Sia

J Clin Virol· September 2009

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Phosphoantigen-expanded human gammadelta T cells display potent cytotoxicity against monocyte-derived macrophages infected with human and avian influenza viruses.
Gang Qin, Huawei Mao, Jian Zheng, Sin Fun Sia, Yinping Liu

J Infect Dis· September 2009

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Toll-like receptors, chemokine receptors and death receptor ligands responses in SARS coronavirus infected human monocyte derived dendritic cells.
Helen K W Law, Chung Yan Cheung, Sin Fun Sia, Yuk On Chan, J S Malik Peiris

BMC Immunol· June 2009

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